scholarly journals Measles - an old children's disease to remember

2018 ◽  
Vol 51 (1) ◽  
pp. 69-74
Author(s):  
Marta Custódio ◽  
Tânia Strecht ◽  
Jana Zelinová ◽  
Anabela Marques
Keyword(s):  
Measles Virus ◽  
Rna Virus ◽  
Viral Disease ◽  
World Health ◽  
Effective Vaccine ◽  
Measles Outbreak ◽  
The Family ◽  
The World ◽  
Health Organization ◽  
In The Beginning

Measles is a serious, highly contagious viral disease. The measles virus is a single-stranded, RNA virus of the genus Morbillivirus within the family Paramyxoviridae, transmitted by air, through droplets of aerosols or by direct contact with respiratory secretions of infected individuals. The infection is acquired through the mucosa of respiratory tract or conjunctiva. In 2005, the World Health Organization established that measles eradication in the European Region should be achieved by 2010, but despite the measures adopted by the various countries, measles re-emerged, with 10271 cases reported only in 2013 in 30 states of European Union, with more than 91% of them in Germany, Italy, Netherland and United Kingdom. In the beginning of 2017, Portugal was threatened with a measles outbreak, reporting in the first five months of the year 31 confirmed cases, 20 (65%) of them in adults (18 or older), of which 45% (13) were in health professionals. Because this measles outbreak had so many cases in adults, the authors decided to make a brief review, trying to remember an old infection, not so well known by younger doctors, and that can be overlooked in the approach of the adult patients. The authors also point out that measles virus could virtually be eradicated as there is an effective vaccine and there is no reservoir in nature for the virus other than humans.

scholarly journals Ongoing African measles virus genotype outbreak in Tel Aviv district since April, Israel, 2012

2012 ◽  
Vol 17 (37) ◽  
Author(s):  
E Kopel ◽  
Z Amitai ◽  
M Savion ◽  
Y Aboudy ◽  
E Mendelson ◽  
...  
Keyword(s):  
World Health Organization ◽  
Measles Virus ◽  
World Health ◽  
European Region ◽  
Virus Genotype ◽  
Tel Aviv ◽  
Measles Outbreak ◽  
The World ◽  
The Mean ◽  
Health Organization

A measles outbreak is affecting the Tel Aviv district, Israel, since April 2012. As of 10 September, 99 cases were confirmed, including 63 (64%) migrants of Eritrean and Sudanese origin. All genotyped cases had the African B3 genotype*. The mean age of migrant and non-migrant cases was 6.0±9.6 and 30.2±24.2 years, respectively (p<0.001). The majority of both migrant and non-migrant cases was unvaccinated. This is the second African measles B3 genotype outbreak within the World Health Organization European region in 2012.

Critical Insight into the Attributes of Emerging Novel Coronavirus (COVID-19) in India and Across the World

Coronaviruses ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Gaurav M. Doshi ◽  
Hemen S. Ved ◽  
Ami P. Thakkar
Keyword(s):  
Review Article ◽  
World Health ◽  
Effective Vaccine ◽  
Human Contact ◽  
The World ◽  
Critical Insight ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Insight Into ◽  
Old Drugs

The World Health Organization (WHO) has recently announced the spread of novel coronavirus (nCoV) globally and has declared it a pandemic. The probable source of transmission of the virus, which is from animal to human and human to human contact, has been established. As per the statistics reported by the WHO on 11th April 2020, data has shown that more than sixteen lakh confirmed cases have been identified globally. The reported cases related to nCoV in India have been rising substantially. The review article discusses the characteristics of nCoV in detail with the probability of potentially effective old drugs that may inhibit the virus. The research may further emphasize and draw the attention of the world towards the development of an effective vaccine as well as alternative therapies. Moreover, the article will help to bridge the gap between the new researchers since it’s the current thrust area of research.

scholarly journals Pharmacotherapeutic management of chronic viral hepatitis

2021 ◽  
Vol 2 (4) ◽  
pp. 1-8
Author(s):  
Gabriela Mitea ◽  
Marius Daniel Radu ◽  
Ana Maria Ionescu ◽  
Nicoleta Blebea
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
World Health Organization ◽  
Geographical Area ◽  
Chronic Viral Hepatitis ◽  
World Health ◽  
Effective Vaccine ◽  
Special Importance ◽  
The World ◽  
Health Organization

In infectious diseases, viral hepatitis has an increased incidence, being an important cause of morbidity and mortality, being a "sentinel" indicator of the socio-economic and hygienic-cultural standard of a geographical area. The World Health Organization (WHO) admits the following types of hepatitis viruses: A, B, B + D, C, E, F and G. Among the viral entities recognized by the WHO, a special importance in terms of incidence, evolution over time with the risk of chronicity and the therapeutic options are presented by hepatitis B and C. There is currently an effective vaccine as well as treatment for hepatitis B. There is no vaccine for hepatitis C, but in recent years considerable progress has been made in treating this disease. Also, the introduction of drugs known as direct-acting antivirals makes it possible to cure over 90% of patients within 2-3 months. But in many countries, current drug policies, regulations and prices keep treatment out of the reach of most people with hepatitis. Eradication of viral hepatitis is possible if greater emphasis is placed on prevention, diagnosis and treatment. Vaccination is very important, as it is possible for types A and B of hepatitis. Early diagnosis is also extremely important, given that there are currently very effective drugs that can prevent the development of liver cancer. The WHO also noted that about two million people worldwide become ill each year due to the reuse of syringes and stressed the importance of checking blood donors to see if they are not carriers of hepatitis B or C viruses. Therefore, the purpose of this article is to highlight the pharmacological treatment and the main therapeutic and prevention schemes currently used for patients with these liver diseases. The paper was based on the most popular methods of identification of the latest international information about the treatment of hepatitis (by electronic search using Pubmed, SciFinder, Scirus, GoogleScholar and Web of Science). We also consulted the global literature cited in the hepatitis database of the World Health Organization (WHO) updated frequent from the current literature on this topic.

scholarly journals Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine

2019 ◽  
Author(s):  
Petter I. Andersen ◽  
Klara Krpina ◽  
Aleksandr Ianevski ◽  
Nastassia Shtaida ◽  
Eunji Jo ◽  
...  
Keyword(s):  
Influenza A ◽  
Rift Valley Fever Virus ◽  
Antiviral Agents ◽  
Viral Disease ◽  
World Health ◽  
Valley Fever ◽  
The World ◽  
Health Organization ◽  
Hiv 1

Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Re-purposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), human immunodeficiency virus 1 (HIV-1), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FluAV), niclosamide against HSV-2, brequinar against HIV-1, and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vivo tests.

scholarly journals Penggunaan Aplikasi Google Classroom sebagai Metode Pembelajaran Daring Selama Pandemi Covid-19

2021 ◽  
Vol 14 (2) ◽  
pp. 11-17
Author(s):  
Mirza Ghulamudin Ghulamudin ◽  
Maufur ◽  
Beni Habibi
Keyword(s):  
Distance Learning ◽  
World Health ◽  
Ministry Of Education ◽  
Health Crisis ◽  
Use Of Technology ◽  
The World ◽  
Teachers And Students ◽  
The Government ◽  
Health Organization ◽  
In The Beginning

Covid-19 has now attacked Indonesia, where the spread of the disease is very fast. Not only in Indonesia, but all corners of the world are currently experiencing a health crisis. In the beginning, the spread of Covid-19 had an impact on economic activity which began to sluggish. This also has an impact on the education system in Indonesia. Until several countries decided to close schools and universities. In an effort to prevent the spread of covid-19, the World Health Organization (WHO) recommends temporarily stopping activities that would potentially cause crowds. Even during the outbreak, covid-19 in Indonesia, there were many ways that the government did to prevent its spread through social distancing. Kemendikbud instructed through the Ministry of Education and Culture (Kemendikbud) Directorate of Higher Education Circular No. 1 of 2020 concerning the prevention of the spread of covid-19 in the world of Education to organize distance learning and advise students to learn from their homes. Teachers and students are starting to be required to follow the current situation by using technology as a distance learning medium. One of the media that is being favored by teachers as a learning medium is the Google Classroom application. This application is an application that can make it easier for students and teachers to create effective learning. Given that students today are a generation who are very familiar with the use of technology. The use of technology in learning is an alternative method used by teachers during the Covid-19 Pandemic.

scholarly journals The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection

2020 ◽  
Vol 21 (4) ◽  
pp. 1511 ◽  
Author(s):  
Nícia Rosário-Ferreira ◽  
António J. Preto ◽  
Rita Melo ◽  
Irina S. Moreira ◽  
Rui M. M. Brito
Keyword(s):  
Viral Disease ◽  
Influenza Viruses ◽  
World Health ◽  
World Population ◽  
Structural Protein ◽  
Human Respiratory Tract ◽  
Host Interactions ◽  
The World ◽  
Health Organization

Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it according to the World Health Organization (WHO). Influenza viruses belong to the Orthomyxoviridae family and have a negative sense eight-segment single-stranded RNA genome that encodes 11 different proteins. The only control over influenza seasonal epidemic outbreaks around the world are vaccines, annually updated according to viral strains in circulation, but, because of high rates of mutation and recurrent genetic assortment, new viral strains of influenza are constantly emerging, increasing the likelihood of pandemics. Vaccination effectiveness is limited, calling for new preventive and therapeutic approaches and a better understanding of the virus–host interactions. In particular, grasping the role of influenza non-structural protein 1 (NS1) and related known interactions in the host cell is pivotal to better understand the mechanisms of virus infection and replication, and thus propose more effective antiviral approaches. In this review, we assess the structure of NS1, its dynamics, and multiple functions and interactions, to highlight the central role of this protein in viral biology and its potential use as an effective therapeutic target to tackle seasonal and pandemic influenza.

scholarly journals Obstetrics and gynaecology in the era of COVID-19

2020 ◽  
Vol 9 (11) ◽  
pp. 4777
Author(s):  
Angela Mary George ◽  
Daniel Manoj ◽  
Sowmya Ramani ◽  
Lalropuii . ◽  
Murugan Timiri Palani ◽  
...  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Psychosocial Support ◽  
Viral Disease ◽  
World Health ◽  
Significant Morbidity ◽  
Obstetrics And Gynaecology ◽  
Global Pandemic ◽  
The World ◽  
Health Organization

The World Health Organization has declared the outbreak of COVID-19 as a global pandemic. The alarming levels of spread and severity of the viral disease has resulted in significant morbidity and mortality. Women often face the highest risk of suffering devastating losses from the pandemic. Historically, women’s health has always been inadequately represented in responses to global outbreaks. Resources are often funnelled away from women’s health services towards targets perceived to be more important. Pregnant women with suspected, probable or confirmed COVID-19, should have access to obstetric and foetal medicine, neonatal care as well as mental health and psychosocial support, at facilities ready to tackle maternal and neonatal complications. In this article, we attempt to look at the challenges faced by gynaecologists because of this pandemic, and provide an overview on the current protocols in antenatal care, foetal care, childbirth, and oncological care.

Development of the World Health Organization Measles Programmatic Risk Assessment Tool Using Experience from the 2009 Measles Outbreak in Namibia

Risk Analysis ◽  
2016 ◽  
Vol 37 (6) ◽  
pp. 1072-1081 ◽  
Author(s):  
Jennifer L. Kriss ◽  
Roselina J. De Wee ◽  
Eugene Lam ◽  
Reinhard Kaiser ◽  
Messeret E. Shibeshi ◽  
...  
Keyword(s):  
Risk Assessment ◽  
World Health Organization ◽  
Assessment Tool ◽  
Risk Assessment Tool ◽  
World Health ◽  
Measles Outbreak ◽  
The World ◽  
Health Organization
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