scholarly journals Prevention of Experimental Cerebral Vasospasm by Intracranial Delivery of a Nitric Oxide Donor From a Controlled-Release Polymer

Stroke ◽  
2002 ◽  
Vol 33 (11) ◽  
pp. 2681-2686 ◽  
Author(s):  
Patrik Gabikian ◽  
Richard E. Clatterbuck ◽  
Charles G. Eberhart ◽  
Betty M. Tyler ◽  
Travis S. Tierney ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Cerebral Vasospasm ◽  
Nitric Oxide Donor ◽  
Controlled Release Polymer

Delayed Intracranial Delivery of a Nitric Oxide Donor from a Controlled-release Polymer Prevents Experimental Cerebral Vasospasm in Rabbits

Neurosurgery ◽  
2004 ◽  
Vol 55 (6) ◽  
pp. 1393-1400 ◽  
Author(s):  
Gustavo Pradilla ◽  
Quoc-Anh Thai ◽  
Federico G. Legnani ◽  
Wesley Hsu ◽  
Ryan M. Kretzer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Cerebral Vasospasm ◽  
Nitric Oxide Donor ◽  
Controlled Release Polymer

Intracranial Delivery of the Nitric Oxide Donor Diethylenetriamine/Nitric Oxide from a Controlled-Release Polymer: Toxicity in Cynomolgus Monkeys

Neurosurgery ◽  
2006 ◽  
Vol 58 (5) ◽  
pp. 952-960 ◽  
Author(s):  
Travis S. Tierney ◽  
Gustavo Pradilla ◽  
Paul P. Wang ◽  
Richard E. Clatterbuck ◽  
Rafael J. Tamargo
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Nitric Oxide Donor ◽  
Cynomolgus Monkeys ◽  
Controlled Release Polymer

scholarly journals A new system of nitric oxide donor prolonged delivery on basis of controlled-release polymer, polyhydroxybutyrate

2005 ◽  
Vol 18 (5) ◽  
pp. A51-A51 ◽  
Author(s):  
A BONARTSEV ◽  
A POSTNIKOV ◽  
V MYSHKINA ◽  
M ARTEMIEVA ◽  
N MEDVEDEVA ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Nitric Oxide Donor ◽  
Controlled Release Polymer ◽  
New System

Mitigation of cerebral vasospasm by a nitric oxide donor, SG-75,following subarachnoid hemorrhage in dogs

1997 ◽  
Vol 99 ◽  
pp. S136-S137
Author(s):  
A. Shimizu ◽  
J. Hatada ◽  
N. Tsuzuki ◽  
H. Katoh ◽  
Y. Matsushita
Keyword(s):  
Nitric Oxide ◽  
Subarachnoid Hemorrhage ◽  
Cerebral Vasospasm ◽  
Nitric Oxide Donor

Prevention and Reversal of Experimental Posthemorrhagic Vasospasm by the Periadventitial Administration of Nitric Oxide from a Controlled-release Polymer

Neurosurgery ◽  
2001 ◽  
Vol 49 (4) ◽  
pp. 945-953
Author(s):  
Travis S. Tierney ◽  
Richard E. Clatterbuck ◽  
Christopher Lawson ◽  
Quoc-Anh Thai ◽  
Laurence D. Rhines ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Controlled Release Polymer

scholarly journals Structural heterogeneity in polymeric nitric oxide donor nanoblended coatings for controlled release behaviors

RSC Advances ◽  
2018 ◽  
Vol 8 (68) ◽  
pp. 38792-38800 ◽  
Author(s):  
Hyejoong Jeong ◽  
Kyungtae Park ◽  
Jae-Chan Yoo ◽  
Jinkee Hong
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Structural Heterogeneity ◽  
Nitric Oxide Donor ◽  
Polymeric Coating

Controlled nitric oxide (NO) delivery based on the heterogeneity of polymeric coating structures for local NO treatment.

Controlled release of a nitric oxide donor for the prevention of delayed cerebral vasospasm following experimental subarachnoid hemorrhage in nonhuman primates

2005 ◽  
Vol 103 (4) ◽  
pp. 745-751 ◽  
Author(s):  
Richard E. Clatterbuck ◽  
Philippe Gailloud ◽  
Travis Tierney ◽  
Victoria M. Clatterbuck ◽  
Kieran J. Murphy ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Subarachnoid Hemorrhage ◽  
Controlled Release ◽  
Cerebral Vasospasm ◽  
Cerebral Angiography ◽  
Nonhuman Primates ◽  
Content Type ◽  
Delayed Cerebral Vasospasm ◽  
The Mean ◽  
Fine Print

Object. Results of prior studies in rats and rabbits show that the alteration of vasomotor tone in vasospasm following periadventitial blood exposure may be reversed, at least in part, by the administration of compounds releasing nitric oxide (NO). The authors have now generalized this finding to nonhuman primates. Methods. Ten cynomolgus monkeys underwent cerebral angiography before and 7 days following the induction of subarachnoid hemorrhage (SAH) by the placement of 2 to 3 ml clotted autologous blood around the supraclinoid carotid, proximal anterior cerebral, and proximal middle cerebral arteries. An ethylene vinyl acetate copolymer, either blank (five animals) or containing 20% w/w (Z)-1-[2-(2-aminoethyl)-N-(2-aminoethyl)amino]diazen-1-ium-1,2-diolate (DETA/NO, 4.3 mg/kg; five animals) was placed adjacent to the vessels at the time of surgery. Animals were killed on Day 7 post-SAH following repeated cerebral angiography. The mean percentage of control vascular areal fraction was calculated from angiograms. Cerebral vessels were sectioned and the mean percentage of lumen patency was calculated. One animal that had received the DETA/NO polymer died prior to repeated angiography. In the remaining animals, DETA/NO caused a significant decrease in vasospasm compared with controls, according to both angiographic (84.8 ± 8.6 compared with 56.6 ± 5.2%, respectively, p < 0.05) and histological studies (internal carotid artery 99.3 ± 1.8 compared with 60.1 ± 4.4%, respectively, p < 0.001; middle cerebral artery 98.4 ± 3 compared with 56.1 ± 3.7%, respectively, p < 0.001; and anterior cerebral artery 89.2 ± 8.5 compared with 55.8 ± 6.3%, respectively, p < 0.05). Conclusions. The controlled release of DETA/NO is effective in preventing delayed cerebral vasospasm in an SAH model in nonhuman primates. The death of one animal in the treatment group indicates that the present dosage is at the threshold between therapeutic efficacy and toxicity.

Reversal of Cerebral Vasospasm by the Nitric Oxide Donor SNAP in an Experimental Model of Subarachnoid Haemorrhage

1999 ◽  
Vol 141 (12) ◽  
pp. 1323-1329 ◽  
Author(s):  
T. Kırış ◽  
A. Karasu ◽  
C. Yavuz ◽  
T. Erdem ◽  
F. Ünal ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Subarachnoid Haemorrhage ◽  
Experimental Model ◽  
Cerebral Vasospasm ◽  
Nitric Oxide Donor

Prevention and Reversal of Experimental Posthemorrhagic Vasospasm by the Periadventitial Administration of Nitric Oxide from a Controlled-release Polymer

Neurosurgery ◽  
2001 ◽  
Vol 49 (4) ◽  
pp. 945-953 ◽  
Author(s):  
Travis S. Tierney ◽  
Richard E. Clatterbuck ◽  
Christopher Lawson ◽  
Quoc-Anh Thai ◽  
Laurence D. Rhines ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Controlled Release Polymer
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