scholarly journals Correction to: Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

2021 ◽  
Vol 41 (10) ◽  
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Dna Damage Response ◽  
Muscle Cells ◽  
Damage Response ◽  
Related Transcription Factor

scholarly journals Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

2020 ◽  
Author(s):  
Andrew M. Cobb ◽  
Syabira Yusoff ◽  
Robert Hayward ◽  
Sadia Ahmad ◽  
Mengxi Sun ◽  
...  
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Dna Damage Response ◽  
Genotoxic Stress ◽  
Dna Damage Signaling ◽  
Damage Response ◽  
Related Transcription Factor ◽  
Osteogenic Gene

Objective: The development of ectopic vascular calcification is strongly linked with organismal aging, which is primarily caused by the accumulation of DNA damage over time. As Runx2 (Runt-related transcription factor 2) has been identified as a regulator of vascular smooth muscle cell osteogenic transition, a key component of vascular calcification, we examined the relationship between DNA damage and Runx2 activation. Approach and Results: We found genotoxic stress-stimulated Runx2 accumulation and transactivation of its osteogenic target genes, leading to enhanced calcification. Inhibition of DNA damage signaling attenuated this response. Runx2 localized to sites of DNA damage and participated in DNA repair by regulating phosphorylation events on histone H2AX, with exogenous expression of Runx2 resulting in unrepaired DNA damage and increased apoptosis. Mechanistically, Runx2 was PARylated in response to genotoxic stress, and inhibition of this modification disrupted its localization at DNA lesions and reduced its binding to osteogenic gene promoters. Conclusions: These data identify Runx2 as a novel component of the DNA damage response, coupling DNA damage signaling to both osteogenic gene transcription and apoptosis and providing a mechanism for accelerated mineralization in aging and chronic disease.

Sirtuin 1 deficiency promotes DNA damage in vascular smooth muscle cells and aggravates atherosclerosis

2012 ◽  
Vol 56 (5-6) ◽  
pp. 313
Author(s):  
Sheetal Kumar ◽  
Haixiang Yu ◽  
Nichola Figg ◽  
John Mercer ◽  
Martin R. Bennett ◽  
...  
Keyword(s):  
Dna Damage ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Sirtuin 1

scholarly journals Ischemia Induces Early Expression of a New Transcription Factor (6A3-5) in Kidney Vascular Smooth Muscle Cells

2003 ◽  
Vol 163 (6) ◽  
pp. 2485-2494 ◽  
Author(s):  
Gwenaële Garin ◽  
Chérif Badid ◽  
Brigitte McGregor ◽  
Madeleine Vincent ◽  
Sylviane Guerret ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Early Expression
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