scholarly journals Essential Role of Copper-Zinc Superoxide Dismutase for Ischemia-Induced Neovascularization Via Modulation of Bone Marrow–Derived Endothelial Progenitor Cells

2010 ◽  
Vol 30 (11) ◽  
pp. 2173-2181 ◽  
Author(s):  
Jessika Groleau ◽  
Sylvie Dussault ◽  
Paola Haddad ◽  
Julie Turgeon ◽  
Catherine Ménard ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Superoxide Dismutase ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Essential Role ◽  
Endothelial Progenitor ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Copper Zinc

Abstract 272: Chronic Hyperlipidemia Alters the Population of Endothelial Progenitor Cells in Bone Marrow and Peripheral Circulation via Both ROS-dependent and Independent Mechanisms

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Dylan Z Liu ◽  
Yuqi Cui ◽  
Jason Z Liu ◽  
Lingjuan Liu ◽  
Xin Li ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Ldl Receptor ◽  
Peripheral Circulation ◽  
Cell Number ◽  
Ros Production ◽  
Endothelial Progenitor ◽  
Ros Formation

Background/Aims: Bone marrow (BM)-derived endothelial progenitor cells (EPCs) make significant contribution to the function and integrity of vasculature. The number of EPCs is significantly decreased in hyperlipidemic patients. Reactive oxygen species (ROS) and oxidative stress were considered an important mechanism for the development of atherosclerosis in hyperlipidemia. The present study was to determine the role of ROS production in the changes of EPC population in chronic hyperlipidemia. Methods and Results: EPC numbers and ROS formation in BM and blood were determined in wild-type (WT) male C57BL/6 mice and hyperlipidemic LDL receptor knockout (LDLR-/-) mice with high fat diet for 4 months. Intracellular blood, extracellular BM and blood ROS production was significantly increased in hyperlipidemic LDLR-/- mice that was effectively blocked with N-acetylcysteine treatment. Hyperlipidemia produced complex changes in EPC populations in BM and blood. The c-Kit+/CD31+ cell number was significantly decreased in BM and blood, and the numbers of CD34+/CD133+ cells and Sca-1+/Flk-1+ cells were significantly decreased in blood without change in BM, which were not affected by inhibition of ROS production. Interestingly, blood CD34+/Flk-1+ cell number was significantly increased in hyperlipidemic mice that was prevented when ROS formation was inhibited. Conclusions: Chronic hyperlipidemia produced significant and complex changes in EPC populations in both BM and circulation through both ROS-dependent and ROS-independent mechanisms in mice.

scholarly journals Essential role of prostacyclin in regenerative function of human endothelial progenitor cells

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Tongrong He ◽  
Chen‐Fuh Lam ◽  
Livius V. d'Uscio ◽  
Eric J. Marrotte ◽  
Zvonimir S. Katusic
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Essential Role ◽  
Endothelial Progenitor
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