scholarly journals Progression of Carotid Intima-Media Thickness as Predictor of Vascular Events

2013 ◽  
Vol 33 (9) ◽  
pp. 2273-2279 ◽  
Author(s):  
Damiano Baldassarre ◽  
Fabrizio Veglia ◽  
Anders Hamsten ◽  
Steve E. Humphries ◽  
Rainer Rauramaa ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vascular Events ◽  
Media Thickness

Complementary Impact of Carotid Intima–Media Thickness With Plaque in Associations With Noncardiac Arterial Vascular Events

Angiology ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 122-130 ◽  
Author(s):  
Andrea Kolkenbeck-Ruh ◽  
Angela J. Woodiwiss ◽  
Talib Monareng ◽  
Eitzaz Sadiq ◽  
Philanathi Mabena ◽  
...  
Keyword(s):  
Young Patients ◽  
Intima Media Thickness ◽  
Limb Ischemia ◽  
Carotid Intima Media Thickness ◽  
Receiver Operating Curve ◽  
Vascular Events ◽  
Thrombotic Occlusion ◽  
Media Thickness ◽  
Improved Performance ◽  
The Impact

The ability of carotid intima–media thickness (IMT) to predict risk beyond plaque is controversial. In 952 participants (critical limb ischemia [CLI] or stroke, n = 473; community, n = 479), we assessed whether relationships with events for IMT complement the impact of plaque in young patients depending on the extent of thrombotic versus atherosclerotic disease. The extent of atherosclerotic versus thrombotic occlusion was determined in 54 patients with CLI requiring amputations. Thrombotic occlusion in CLI was associated with younger age ( P < .0001) and less plaque ( P = .02). Independent relations between plaque and CLI were noted in older (>50 years; P < .005 to <.0001) but not younger ( P > .38) participants, while independent relations between plaque and stroke ( P < .005 to <.0001) and between IMT and CLI ( P < .0001) were noted in younger participants. Although in performance (area under the receiver operating curve) for event detection, IMT thresholds failed to add to plaque alone in older patients (0.680 ± 0.020 vs 0.664 ± 0.017, P = .27), IMT improved performance for combined stroke and CLI detection when added to plaque in younger patients (0.719 ± 0.023 vs 0.631 ± 0.026, P < .0001). Because in younger participants the high prevalence of thrombotic occlusion in CLI is associated with less plaque, IMT adds information in associations with arterial vascular events.

scholarly journals Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes: Results From the PROG-IMT Collaboration

Diabetes Care ◽  
2015 ◽  
Vol 38 (10) ◽  
pp. 1921-1929 ◽  
Author(s):  
Matthias W. Lorenz ◽  
Jackie F. Price ◽  
Christine Robertson ◽  
Michiel L. Bots ◽  
Joseph F. Polak ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vascular Events ◽  
Media Thickness

scholarly journals Association Between Uric Acid, Carotid Intima‐Media Thickness, and Cardiovascular Events: Prospective Results From the IMPROVE Study

2021 ◽  
Author(s):  
Massimo R. Mannarino ◽  
Matteo Pirro ◽  
Bruna Gigante ◽  
Kai Savonen ◽  
Sudhir Kurl ◽  
...  
Keyword(s):  
Uric Acid ◽  
Carotid Atherosclerosis ◽  
Elevated Serum ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cvd Risk ◽  
Vascular Events ◽  
Media Thickness ◽  
Hazard Ratios ◽  
Increased Risk

Background The association between elevated serum uric acid (SUA), cardiovascular disease (CVD) risk, and carotid atherosclerosis has long been explored, and contrasting results have been reported. Therefore, the role of SUA as an independent risk factor for vascular events (VEs) and carotid atherosclerosis deserves further attention. We investigated the relationship between SUA, incident VEs, carotid intima‐media thickness (cIMT), and cIMT progression in subjects at moderate‐to‐high CVD risk. Methods and Results In the IMPROVE (IMT‐Progression as Predictors of VEs) study, 3686 participants (median age 64 years; 48% men) with ≥ 3 vascular risk factors, free from VEs at baseline, were grouped according to SUA quartiles (division points: 244–284–328 µmol/L in women, 295–336–385 µmol/L in men). Carotid‐IMT and its 15‐month progression, along with incident VEs, were recorded. A U‐shaped association between SUA and VEs was observed in men, with 2.4‐fold ( P = 0.004) and 2.5‐fold ( P = 0.002) increased CVD risk in the first and fourth SUA quartiles as compared with the second. Adjusted hazard ratios (HRs) for cerebro‐VEs in men were the highest (first and fourth quartile versus second: HR, 5.3, P = 0.010 and HR, 4.4, P = 0.023, respectively). SUA level was independently associated with cIMT progression in men (β = 0.068, P = 0.014). No significant association between SUA levels, CVD end points, and cIMT progression were found in women. Conclusions Both low and high SUA levels are associated with an increased risk of VEs in men at moderate‐to‐high CVD risk but not in women. Only elevated SUA levels predict cIMT progression and at a lesser but not significant extent in women.

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