scholarly journals Laminar Pattern of Mineral Calcium-Phosphorus Deposits in a Human Carotid Plaque

Circulation ◽  
2010 ◽  
Vol 121 (17) ◽  
pp. 1971-1973 ◽  
Author(s):  
Luigina Guasti ◽  
Franca Marino ◽  
Terenzio Congiu ◽  
Matteo Tozzi ◽  
Laura Schembri ◽  
...  
Keyword(s):  
Carotid Plaque ◽  
Calcium Phosphorus ◽  
Laminar Pattern ◽  
Human Carotid

scholarly journals Calmodulin Expression Distinguishes the Smooth Muscle Cell Population of Human Carotid Plaque

2013 ◽  
Vol 183 (3) ◽  
pp. 996-1009 ◽  
Author(s):  
Matteo Coen ◽  
Giovanna Marchetti ◽  
Patricia M. Palagi ◽  
Carlotta Zerbinati ◽  
Giuseppe Guastella ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Population ◽  
Muscle Cell ◽  
Carotid Plaque ◽  
Human Carotid

Automatic Classification of Human Carotid Plaque Features, In Vivo, Using Multiple Forms of ARFI Data

2021 ◽  
Author(s):  
Gabriela Torres ◽  
Melissa C. Caughey ◽  
Keerthi Anand ◽  
Jonathon W. Homeister ◽  
Mark A. Farber ◽  
...  
Keyword(s):  
Carotid Plaque ◽  
Automatic Classification ◽  
Multiple Forms ◽  
Human Carotid

Abstract 136: Identification of Melanoregulin as Novel Marker for Atherosclerosis

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Silvia Aldi ◽  
Ljubica Perisic ◽  
Mariette Lengquist ◽  
Malin Kronqvist ◽  
Joy Roy ◽  
...  
Keyword(s):  
Carotid Plaque ◽  
Vascular Diseases ◽  
Human Monocyte ◽  
Foam Cells ◽  
Aortic Tissue ◽  
Atherosclerosis Progression ◽  
Protein Levels ◽  
Atherosclerotic Lesions ◽  
Novel Biomarkers ◽  
Human Carotid

Introduction: Novel biomarkers identification in atherosclerosis is needed for early detection/intervention of vascular diseases. Impaired lysosomal function and autophagy cause abnormal lipid accumulation in foam cells and contribute to atherosclerosis progression. By microarray of human carotid plaques in the Biobank of Karolinska Endarterectomies (BiKE), we found that melanoregulin (MREG), a protein associated with lysosomes, phagocytosis and autophagy and previously not associated with atherosclerosis, was significantly up-regulated in symptomatic (S) versus asymptomatic (AS) patients. MREG expression was also significantly correlated to inflammatory, lipid and endo/lysosome markers. Hypothesis: We hypothesized that MREG modulates clearance of engulfed lipids and extracellular material in lipid-loaded foam cells. Methods: MREG mRNA and protein levels were evaluated in human carotid plaque tissue from S and AS patients by qPCR and immunohistochemistry, respectively. MREG, together with lysosome and lipid markers (LAMP2 and PLIN2 respectively) was identified by immunofluorescence in human monocyte cells (THP-1), loaded with modified LDL. To investigate autophagy/MREG correlation, THP-1 cells were incubated with autophagy inhibitor (chloroquine, CQ) and MREG mRNA was assessed by qPCR. Results: MREG mRNA is elevated in human atherosclerotic lesions versus normal artery (11.21 folds, P<0.0001). In human aortic tissue MREG expression is correlated to the lesion progression and localizes in infiltrating macrophage-derived foam cells. In the human carotid plaque, MREG co-localizes with CD68+ and PLIN2+ cells, lined to the necrotic core. MREG protein was also detected in PMA-differentiated THP-1 cells. In lipid-loaded THP-1, MREG is co-localized with lysosomal LAMP2. Moreover, MREG expression is increased in THP-1 cells by incubation with PMA, starving medium and CQ. Conclusions: We show here for the first time that MREG is expressed in atherosclerotic lesions and is associated with endo/lysosomes in human macrophages. Furthermore we show that autophagy inhibition increases MREG mRNA expression. Future studies will investigate how MREG expression levels will affect phagocytic activity of lipid-loaded macrophages.

Dual roles of heparanase in human carotid plaque calcification

2019 ◽  
Vol 283 ◽  
pp. 127-136 ◽  
Author(s):  
Silvia Aldi ◽  
Linnéa Eriksson ◽  
Malin Kronqvist ◽  
Mariette Lengquist ◽  
Marie Löfling ◽  
...  
Keyword(s):  
Carotid Plaque ◽  
Dual Roles ◽  
Human Carotid

scholarly journals Advanced human carotid plaque progression correlates positively with flow shear stress using follow-up scan data: An in vivo MRI multi-patient 3D FSI study

2010 ◽  
Vol 43 (13) ◽  
pp. 2530-2538 ◽  
Author(s):  
Chun Yang ◽  
Gador Canton ◽  
Chun Yuan ◽  
Marina Ferguson ◽  
Thomas S. Hatsukami ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Plaque ◽  
Plaque Progression ◽  
Flow Shear ◽  
Flow Shear Stress ◽  
Scan Data ◽  
Human Carotid

Attenuation compensation of ultrasound backscatter from human carotid plaque

2018 ◽  
Vol 144 (3) ◽  
pp. 1888-1888
Author(s):  
Sheronica L. James ◽  
Russell Fedewa ◽  
Heather Gornik ◽  
Sean Lyden ◽  
D. Geoffrey Vince
Keyword(s):  
Carotid Plaque ◽  
Attenuation Compensation ◽  
Ultrasound Backscatter ◽  
Human Carotid

High-resolution multicontrast-weighted MR imaging from human carotid endarterectomy specimens to assess carotid plaque components

2008 ◽  
Vol 18 (12) ◽  
pp. 2912-2921 ◽  
Author(s):  
Sebastiano Fabiano ◽  
Stefano Mancino ◽  
Matteo Stefanini ◽  
Marcello Chiocchi ◽  
Alessandro Mauriello ◽  
...  
Keyword(s):  
High Resolution ◽  
Mr Imaging ◽  
Carotid Endarterectomy ◽  
Carotid Plaque ◽  
Human Carotid

Integrin and Matrix Metalloproteinase Expression in Human Carotid Plaque

2009 ◽  
Vol 155 (1) ◽  
pp. 157-164 ◽  
Author(s):  
Carlos A. Murillo ◽  
Kenneth J. Woodside ◽  
Qian Guo ◽  
Shu Zhang ◽  
Kathleen L. O'Connor ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Carotid Plaque ◽  
Human Carotid
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