scholarly journals Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury

2019 ◽  
Vol 125 (5) ◽  
pp. 507-519 ◽  
Author(s):  
Nicoletta Sorvillo ◽  
Daniella M. Mizurini ◽  
Carmen Coxon ◽  
Kimberly Martinod ◽  
Ronak Tilvawala ◽  
...  
Keyword(s):  
Peptidylarginine Deiminase ◽  
Vessel Injury ◽  
String Formation

Histology of the vertebral artery–dural junction: relevance to posterolateral approaches to the skull base

2019 ◽  
pp. 1-6
Author(s):  
Robert C. Rennert ◽  
Martin P. Powers ◽  
Jeffrey A. Steinberg ◽  
Takanori Fukushima ◽  
John D. Day ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Vertebral Artery ◽  
Skull Base ◽  
Histological Analysis ◽  
Foramen Magnum ◽  
Entry Site ◽  
Microsurgical Technique ◽  
Vessel Injury ◽  
Far Lateral ◽  
Clear Delineation

OBJECTIVEThe far-lateral and extreme-lateral infrajugular transcondylar–transtubercular exposure (ELITE) and extreme-lateral transcondylar transodontoid (ELTO) approaches provide access to lesions of the foramen magnum, inferolateral to mid-clivus, and ventral pons and medulla. A subset of pathologies in this region require manipulation of the vertebral artery (VA)–dural interface. Although a cuff of dura is commonly left on the VA to avoid vessel injury during these approaches, there are varying descriptions of the degree of VA-dural separation that is safely achievable. In this paper the authors provide a detailed histological analysis of the VA-dural junction to guide microsurgical technique for posterolateral skull base approaches.METHODSAn ELITE approach was performed on 6 preserved adult cadaveric specimens. The VA-dural entry site was resected, processed for histological analysis, and qualitatively assessed by a neuropathologist.RESULTSHistological analysis demonstrated a clear delineation between the intima and media of the VA in all specimens. No clear plane was identified between the connective tissue of the dura and the connective tissue of the VA adventitia.CONCLUSIONSThe VA forms a contiguous plane with the connective tissue of the dura at its dural entry site. When performing posterolateral skull base approaches requiring manipulation of the VA-dural interface, maintenance of a dural cuff on the VA is critical to minimize the risk of vascular injury.

Lymphaticovenular anastomosis for lymph vessel injury in the pelvis and groin

Microsurgery ◽  
2021 ◽  
Author(s):  
Hideki Kadota ◽  
Ryo Shimamoto ◽  
Seita Fukushima ◽  
Yusuke Inatomi ◽  
Ko Ikemura ◽  
...  
Keyword(s):  
Lymph Vessel ◽  
Vessel Injury

scholarly journals Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Anna K. Uryga ◽  
Mandy O. J. Grootaert ◽  
Abel M. Garrido ◽  
Sebnem Oc ◽  
Kirsty Foote ◽  
...  
Keyword(s):  
Dna Damage ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Immune Cell ◽  
Cell Senescence ◽  
Telomeric Dna ◽  
Neointimal Formation ◽  
Persistent Inflammation ◽  
Vessel Injury ◽  
Stress Induced Premature Senescence

AbstractAccumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced atherosclerotic lesions show reduced cell proliferation, extensive and persistent DNA damage, and features of premature cell senescence. Here, we report that stress-induced premature senescence (SIPS) and stable expression of a telomeric repeat-binding factor 2 protein mutant (TRF2T188A) induce senescence of human VSMCs, associated with persistent telomeric DNA damage. VSMC senescence is associated with formation of micronuclei, activation of cGAS-STING cytoplasmic sensing, and induction of multiple pro-inflammatory cytokines. VSMC-specific TRF2T188A expression in a multicolor clonal VSMC-tracking mouse model shows no change in VSMC clonal patches after injury, but an increase in neointima formation, outward remodeling, senescence and immune/inflammatory cell infiltration or retention. We suggest that persistent telomere damage in VSMCs inducing cell senescence has a major role in driving persistent inflammation in vascular disease.

scholarly journals Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Antonio Julià ◽  
María López-Lasanta ◽  
Francisco Blanco ◽  
Antonio Gómez ◽  
Isabel Haro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Retrospective Cohort ◽  
Tumor Necrosis ◽  
Peptidylarginine Deiminase ◽  
Das28 Score ◽  
Factor Therapy ◽  
Interaction Term ◽  
Antibody Interactions ◽  
Necrosis Factor

Abstract Background Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50–60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients for anti-TNF therapy. Rheumatoid factor (RF) and anti-cyclic-citrullinated antibodies (anti-CCP) have been evaluated as biomarkers of response but the results have shown limited consistency. Anti-carbamylated protein (anti-CarP) and anti-peptidylarginine deiminase type 4 (anti-PAD4) antibodies have been much less studied. Despite being linked to common immune processes, the interaction between these markers has not been evaluated yet. Our aim was to analyze the interaction between these four antibodies in relation to the response to anti-TNF therapy. Methods For this objective, a prospective cohort of n = 80 RA patients starting anti-TNF therapy was recruited. Serum determinations at baseline were performed for RF, anti-CCP, anti-CarP and anti-PAD4 antibodies using enzyme-linked immunosorbent assays (ELISA). The clinical response to anti-TNF therapy was determined at week 12 using the change in DAS28 score. Association was performed using multivariate linear regression adjusting for baseline DAS28, sex and age. Results The interaction between pairs of antibodies was tested by the addition of an interaction term. We found two highly significant antibody interactions associated with treatment response: anti-CarP with anti-PAD4 (p = 0.0062), and anti-CCP with RF (p = 0.00068). The latter antibody interaction was replicated in an independent retrospective cohort of RA patients (n = 199, p = 0.04). Conclusions The results of this study suggest that antibody interaction effects are important factors in the response to anti-TNF therapy in RA.

Peptidylarginine Deiminase Inhibition by Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Model of Endotoxic Shock in Rabbits

2020 ◽  
Vol 231 (4) ◽  
pp. S326-S327
Author(s):  
Ali Siddiqui ◽  
Aaron M. Williams ◽  
Umar F. Bhatti ◽  
Ben Biesterveld ◽  
Yuzi Tian ◽  
...  
Keyword(s):  
Endotoxic Shock ◽  
Kidney Injury ◽  
Peptidylarginine Deiminase

Porphyromonas gingivalis peptidylarginine deiminase substrate specificity

Anaerobe ◽  
2013 ◽  
Vol 23 ◽  
pp. 102-108 ◽  
Author(s):  
Syatirah-Najmi Abdullah ◽  
Elizabeth-Anne Farmer ◽  
Llewellyn Spargo ◽  
Richard Logan ◽  
Neville Gully
Keyword(s):  
Substrate Specificity ◽  
Porphyromonas Gingivalis ◽  
Peptidylarginine Deiminase

O49. Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury

Nitric Oxide ◽  
2008 ◽  
Vol 19 ◽  
pp. 31
Author(s):  
Marsha P. Cole ◽  
Tanja Rudoph ◽  
Bruce A. Freeman ◽  
Philip Michael Bauer
Keyword(s):  
Fatty Acid ◽  
Acid Inhibition ◽  
Neointima Formation ◽  
Vessel Injury ◽  
Fatty Acid Inhibition

P097 Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes

Cytokine ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 550
Author(s):  
S. Ferrari-Lacraz ◽  
M. Sebbag ◽  
R. Chicheportiche ◽  
C. Foulquier ◽  
G. Serre ◽  
...  
Keyword(s):  
T Cells ◽  
Human Monocytes ◽  
Peptidylarginine Deiminase

scholarly journals An extension to models for cosmic string formation

1995 ◽  
Vol 364 (3) ◽  
pp. 149-156 ◽  
Author(s):  
Andrew Yates ◽  
T.W.B. Kibble
Keyword(s):  
Cosmic String ◽  
String Formation
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