scholarly journals Correction to: Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations

2021 ◽  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Blood Institute ◽  
National Heart ◽  
National Heart Lung ◽  
Clinical Considerations ◽  
Institute Workshop

Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects

2021 ◽  
Author(s):  
Brian P. Delisle ◽  
Alfred L. George ◽  
Jeanne M. Nerbonne ◽  
Joseph T. Bass ◽  
Crystal M. Ripplinger ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Animal Studies ◽  
Heart Function ◽  
Cell Types ◽  
Unexpected Death ◽  
Blood Institute ◽  
Physiological Importance ◽  
National Heart ◽  
National Heart Lung

Sudden cardiac death (SCD), the unexpected death due to acquired or genetic cardiovascular disease, follows distinct 24-hour patterns in occurrence. These 24-hour patterns likely reflect daily changes in arrhythmogenic triggers and the myocardial substrate caused by day/night rhythms in behavior, the environment, and endogenous circadian mechanisms. To better address fundamental questions regarding the circadian mechanisms, the National Heart, Lung, and Blood Institute convened a workshop, Understanding Circadian Mechanisms of Sudden Cardiac Death. We present a 2-part report of findings from this workshop. Part 1 summarizes the workshop and serves to identify research gaps and opportunities in the areas of basic and translational research. Among the gaps noted: a lack of standardization in animal studies for reporting environmental conditions (eg, timing of experiments relative to the light dark cycle or animal housing temperatures) that can impair rigor and reproducibility. Workshop participants also pointed to uncertainty regarding the importance of maintaining normal circadian rhythmic synchrony and the potential pathological impact of desynchrony in SCD risk. One related question raised was whether circadian mechanisms can be targeted to reduce SCD risk. Finally, the experts underscored the need for studies aimed at determining the physiological importance of circadian clocks in the many different cell types important to normal heart function and SCD. Addressing these gaps could lead to new therapeutic approaches/molecular targets that can mitigate the risk of SCD not only at certain times but over the entire 24-hour period.

Understanding Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations

2021 ◽  
Author(s):  
Brian P. Delisle ◽  
Alfred L. George ◽  
Jeanne M. Nerbonne ◽  
Joseph T. Bass ◽  
Crystal M. Ripplinger ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Sudden Cardiac Death ◽  
Circadian Rhythms ◽  
Cardiac Death ◽  
Physiological Responses ◽  
Blood Institute ◽  
Biological Variables ◽  
National Heart ◽  
National Heart Lung

Sudden cardiac death (SCD) is the sudden, unexpected death due to abrupt loss of heart function secondary to cardiovascular disease. In certain populations living with cardiovascular disease, SCD follows a distinct 24-hour pattern in occurrence, suggesting day/night rhythms in behavior, the environment, and endogenous circadian rhythms result in daily spans of increased vulnerability. The National Heart, Lung, and Blood Institute convened a workshop, Understanding Circadian Mechanisms of Sudden Cardiac Death to identify fundamental questions regarding the role of the circadian rhythms in SCD. Part 2 summarizes research gaps and opportunities in the areas of population and clinical research identified in the workshop. Established research supports a complex interaction between circadian rhythms and physiological responses that increase the risk for SCD. Moreover, these physiological responses themselves are influenced by several biological variables, including the type of cardiovascular disease, sex, age, and genetics, as well as environmental factors. The emergence of new noninvasive biotechnological tools that continuously measure key cardiovascular variables, as well as the identification of biomarkers to assess circadian rhythms, hold promise for generating large-scale human data sets that will delineate which subsets of individuals are most vulnerable to SCD. Additionally, these data will improve our understanding of how people who suffer from circadian disruptions develop cardiovascular diseases that increase the risk for SCD. Emerging strategies to identify new biomarkers that can quantify circadian health (eg, environmental, behavioral, and internal misalignment) may lead to new interventions and therapeutic targets to prevent the progression of cardiovascular diseases that cause SCD.

scholarly journals Implementation Research to Address the United States Health Disadvantage: Report of a National Heart, Lung, and Blood Institute Workshop

Global Heart ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 65 ◽  
Author(s):  
Michael M. Engelgau ◽  
K.M. Venkat Narayan ◽  
Majid Ezzati ◽  
Luis A. Salicrup ◽  
Deshiree Belis ◽  
...  
Keyword(s):  
United States ◽  
Implementation Research ◽  
The United States ◽  
Blood Institute ◽  
National Heart ◽  
National Heart Lung ◽  
Institute Workshop

scholarly journals Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop

JCI Insight ◽  
2017 ◽  
Vol 2 (9) ◽  
Author(s):  
Vibha N. Lama ◽  
John A. Belperio ◽  
Jason D. Christie ◽  
Souheil El-Chemaly ◽  
Michael C. Fishbein ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Consensus Statement ◽  
Blood Institute ◽  
National Heart ◽  
National Heart Lung ◽  
Institute Workshop

Prevalence and etiology of idiopathic dilated cardiomyopathy (summary of a National Heart, Lung, and Blood Institute Workshop)

1992 ◽  
Vol 69 (17) ◽  
pp. 1458-1466 ◽  
Author(s):  
Teri A. Manolio ◽  
Kenneth L. Baughman ◽  
Richard Rodeheffer ◽  
Thomas A. Pearson ◽  
J.David Bristow ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Blood Institute ◽  
National Heart ◽  
National Heart Lung ◽  
Institute Workshop
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