scholarly journals Neutral Endopeptidase Is Activated in Cardiomyocytes in Human Aortic Valve Stenosis and Heart Failure

Circulation ◽  
2002 ◽  
Vol 105 (3) ◽  
pp. 286-289 ◽  
Author(s):  
Jens Fielitz ◽  
Andreas Dendorfer ◽  
Reinhard Pregla ◽  
Elisabeth Ehler ◽  
Heinz R. Zurbrügg ◽  
...  
Keyword(s):  
Heart Failure ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Neutral Endopeptidase ◽  
Human Aortic Valve

A case of adult unicuspid aortic valve stenosis that underwent emergent aortic valve replacement for severe heart failure

Choonpa Igaku ◽  
2020 ◽  
Vol 47 (5) ◽  
pp. 191-195
Author(s):  
Masayuki YAMASAKI ◽  
Yoshio TAKEUCHI ◽  
Keitaro NAKAGIRI ◽  
Rie TAKAOKA ◽  
Kimika YOSHINAGA ◽  
...  
Keyword(s):  
Heart Failure ◽  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Aortic Valve Stenosis ◽  
Severe Heart Failure

Abstract 15209: LPA Variants Are Associated With Aortic Valve Stenosis, Heart Failure and Chronic Kidney Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Ozan Dikilitas ◽  
Benjamin A Satterfield ◽  
Maya Safarova ◽  
Shoa L Clarke ◽  
Catherine Tcheandjieu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
European Ancestry ◽  
Atherosclerotic Cardiovascular Disease ◽  
Disease Phenotypes ◽  
Emerge Network ◽  
Artery Disease

Background: The pathophysiology of lipoprotein (a) [Lp(a)] remains obscure. We conducted a phenome wide analysis study (PheWAS) to identify pleiotropic effects of LPA variants. Methods: Among 51,843 European-ancestry participants (age 58±16 years, 54% female) of the electronic MEdical Records and Genomics (eMERGE) network we assessed whether LPA variants exhibited pleiotropic affects through an electronic health record-based PheWAS. We adjusted significant associations by presence of atherosclerotic cardiovascular disease (ASCVD; defined as a composite of coronary heart disease, cerebrovascular disease, and peripheral artery disease) to determine whether those associations were independent of ASCVD. Results: In PheWAS analysis, we tested 864 phecodes with 36 independent LPA variants. We identified 21 significant associations with non-ASCVD phenotypes including heart failure, aortic valve stenosis, and chronic kidney disease of which 14 were replicated across independent cohorts. The strength of associations between the LPA variant rs10455872 and both heart failure and aortic valve stenosis related phecodes were significantly attenuated after adjustment for ASCVD. However, the association with chronic kidney disease phecode remained independent following adjustment for ASCVD without any attenuation in the estimated odds ratio (Table). Conclusions: LPA genetic variants were associated with aortic valve stenosis, heart failure and chronic kidney disease. The observed association of LPA variant rs10455872 with aortic stenosis and heart failure appear to be partially mediated by ASCVD, while the association with chronic kidney disease appears to be independent of ASCVD. Additional studies are needed to elucidate potential mechanisms by which Lp(a) may contribute to the pathogenesis of non-ASCVD disease phenotypes.

Augmented cannabinoid receptors expression in human aortic valve stenosis

2010 ◽  
Vol 145 (3) ◽  
pp. 535-537 ◽  
Author(s):  
Yoshiro Naito ◽  
Takeshi Tsujino ◽  
Hirokuni Akahori ◽  
Mitsumasa Ohyanagi ◽  
Masataka Mitsuno ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Cannabinoid Receptors ◽  
Human Aortic Valve

scholarly journals Increase in tissue endothelin-1 and ETA receptor levels in human aortic valve stenosis

2008 ◽  
Vol 30 (2) ◽  
pp. 242-249 ◽  
Author(s):  
T. Peltonen ◽  
P. Taskinen ◽  
J. Napankangas ◽  
H. Leskinen ◽  
P. Ohtonen ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Endothelin 1 ◽  
Eta Receptor ◽  
Human Aortic Valve

Transcatheter Treatment of Degenerative Critical Aortic Valve Stenosis in a Patient With Severe Heart Failure and Chronic Lymphocytic Leukemia

Kardiologiia ◽  
2015 ◽  
Vol 1_2015 ◽  
pp. 82-87 ◽  
Author(s):  
M.S. Safarova Safarova ◽  
T.E. Imaev Imaev ◽  
Y.Y. Lorie Lorie ◽  
M.A. Saidova Saidova ◽  
M.V. Ezhov Ezhov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Lymphocytic Leukemia ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Severe Heart Failure ◽  
Lymphocytic Leukemia

scholarly journals Progression of human aortic valve stenosis is associated with tenascin-C expression

2002 ◽  
Vol 39 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Jari Satta ◽  
Jukka Melkko ◽  
Raimo Pöllänen ◽  
Juha Tuukkanen ◽  
Paavo Pääkkö ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Tenascin C ◽  
Human Aortic Valve

scholarly journals Higher Acceleration/Ejection Time Ratio Predicts Impaired Outcome in Aortic Valve Stenosis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Eigir Einarsen ◽  
Dana Cramariuc ◽  
Edda Bahlmann ◽  
Helga Midtbo ◽  
John B. Chambers ◽  
...  
Keyword(s):  
Heart Failure ◽  
Aortic Valve ◽  
Ejection Fraction ◽  
Aortic Valve Stenosis ◽  
Cardiovascular Death ◽  
Left Ventricular ◽  
Hazard Ratio ◽  
Left Ventricular Ejection ◽  
Heart Failure Hospitalization ◽  
Ejection Time

Background: Acceleration time (AT)/ejection time (ET) ratio is a marker of aortic valve stenosis (AS) severity and predicts outcome in moderate-severe AS. Methods: We explored the association of increased AT/ET ratio on prognosis in 1530 asymptomatic patients with presumably mild-moderate AS, normal ejection fraction, and without known diabetes or cardiovascular disease. Patients were part of the SEAS study (Simvastatin Ezetimibe Aortic Stenosis). Patients were grouped according to the optimal AT/ET ratio threshold to predict cardiovascular death and heart failure hospitalization. Low-gradient severe AS was identified as combined valve area ≤1.0 cm 2 and mean gradient <40 mm Hg. Outcome was assessed in Cox regression analyses, and results are reported as hazard ratio and 95% CI. Results: Higher AT/ET ratio was significantly associated with lower systolic blood pressure, lower left ventricular ejection fraction, lower stress-corrected midwall shortening, low flow, and with higher left ventricular mass and higher peak aortic jet velocity. AT/ET ratio ≥0.32 provided the optimal cutoff for predicting incident cardiovascular death and heart failure hospitalization in the total study sample. In patients with low-gradient severe AS, this threshold was >0.32. AT/ET ratio ≥0.32 had a 79% higher risk of cardiovascular death and heart failure hospitalization (hazard ratio, 1.79 [95% CI, 1.20–2.68]). In patients with low-gradient severe AS, AT/ET ratio >0.32 was associated with a 2-fold higher risk of cardiovascular death and heart failure hospitalization (hazard ratio, 2.15 [95% CI, 1.22–3.77]). Conclusions: In asymptomatic nonsevere AS and low-gradient severe AS, higher AT/ET ratio was associated with increased cardiovascular morbidity and mortality. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00092677.

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