scholarly journals Plasma Concentration of C-Reactive Protein and Risk of Ischemic Stroke and Transient Ischemic Attack: The Framingham Study

Stroke ◽  
2001 ◽  
Vol 32 (11) ◽  
pp. 2575-2579 ◽  
Author(s):  
N. S. Rost ◽  
P. A. Wolf ◽  
C. S. Kase ◽  
M. Kelly-Hayes ◽  
H. Silbershatz ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Plasma Concentration ◽  
Transient Ischemic Attack ◽  
Framingham Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Ischemic Attack

scholarly journals C-Reactive Protein Predicts Further Ischemic Events in Patients With Transient Ischemic Attack or Lacunar Stroke

2020 ◽  
Vol 11 ◽  
Author(s):  
Manuela Mengozzi ◽  
Frances A. Kirkham ◽  
Esme E. R. Girdwood ◽  
Eva Bunting ◽  
Erin Drazich ◽  
...  
Keyword(s):  
Transient Ischemic Attack ◽  
Lacunar Stroke ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Ischemic Attack ◽  
Ischemic Events

scholarly journals Plasma C-Reactive Protein, Systolic Hypertension and Risk of Ischemic Stroke and TIA: The Framingham Study

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 330-331
Author(s):  
Natalia S Rost ◽  
Carlos S Kase ◽  
Philip A Wolf ◽  
Joseph M Massaro ◽  
Margaret Kelly-Hayes ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Risk Ratio ◽  
Reference Group ◽  
Cox Proportional Hazards ◽  
Study Cohort ◽  
Framingham Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increased Risk ◽  
Elevated Systolic Blood Pressure

83 Background: The role of plasma C-reactive protein (CRP) as marker of cerebrovascular risk is currently under investigation. We evaluated relative risk of developing first ischemic stroke and TIA among the patients with elevated systolic blood pressure (SBP) and/or elevated plasma CRP levels versus those patients with unelevated SBP and unelevated CRP. Methods: We studied 591 men and 868 women of the original Framingham Study cohort who were free of stroke and TIA at the time of their 1980–1982 clinic exam. Sex-specific Cox proportional hazards regressions were used to quantify the risk of 14-year incidence of ischemic stroke/TIA associated with elevated SBP and CRP. Unadjusted models and models adjusted for age, smoking, total & HDL cholesterol, and diabetes were used. SBP and CRP were included in the Cox models as sex-specific quartiles. Risk ratios of first ischemic stroke/TIA for individuals with elevated (in the upper quartile) SBP (SBP+) and CRP (CRP+) were determined using the SBP-/CRP- individuals as a reference group. Similarly, simultaneous evaluation of the risk of first ischemic stroke/TIA was done for SBP+/CRP- and SBP-/CRP+ using the individuals in SBP-/CRP- as a reference group. Results: Relative to SBP-/CRP- men (incidence of first ischemic stroke/TIA of 36/328, or 11.0%), SBP+/CRP+ men (where incidence was 8/32, or 25.0%) had unadjusted risk ratio of 3.56 (p=0.001). This ratio was nearly twice that for SBP+/CRP- men (incidence=20/115, or 17.4%; RR=1.89, p=0.023). Relative to SBP-/CRP- women (incidence= 45/485, or 9.3%), the unadjusted risk ratio increased from 2.03 in SBP+/CRP- women (incidence=27/166, or 16.3%; p=0.001) to 3.44 in SBP+/CRP+ women (incidence=15/58, or 25.9%; p<0.001). Adjustment for age did not significantly alter this relationship. Following multivariate adjustment, risk of developing first ischemic stroke/TIA remained significantly elevated in SBP+/CRP+ men (RR=2.7; p=0.018) and women (RR=2.06; p=0.027). Conclusion: Having both CRP levels and systolic BP above the 75 th percentile for each of these parameters significantly increased risk of developing first ischemic stroke/TIA in both sexes.

Triggered C-reactive protein (CRP) concentrations and the CRP gene −717A>G polymorphism in acute stroke or transient ischemic attack

2007 ◽  
Vol 14 (3) ◽  
pp. 315-320 ◽  
Author(s):  
E. Ben-Assayag ◽  
S. Shenhar-Tsarfaty ◽  
I. Bova ◽  
S. Berliner ◽  
L. Shopin ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Transient Ischemic Attack ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Ischemic Attack

C-reactive protein predicts further ischemic events in transient ischemic attack patients

2007 ◽  
Vol 115 (1) ◽  
pp. 60-66 ◽  
Author(s):  
F. Purroy ◽  
J. Montaner ◽  
C. A. Molina ◽  
P. Delgado ◽  
J. F. Arenillas ◽  
...  
Keyword(s):  
Transient Ischemic Attack ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Ischemic Attack ◽  
Ischemic Events

scholarly journals C-Reactive Protein Predicts Further Ischemic Events in First-Ever Transient Ischemic Attack or Stroke Patients With Intracranial Large-Artery Occlusive Disease

Stroke ◽  
2003 ◽  
Vol 34 (10) ◽  
pp. 2463-2468 ◽  
Author(s):  
Juan F. Arenillas ◽  
José Álvarez-Sabín ◽  
Carlos A. Molina ◽  
Pilar Chacón ◽  
Joan Montaner ◽  
...  
Keyword(s):  
Transient Ischemic Attack ◽  
Occlusive Disease ◽  
Large Artery ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Reactive Protein ◽  
Ischemic Attack ◽  
Ischemic Events

Clinical characteristics of inpatients with Coronavirus disease 2019 and acute ischemic stroke: from epidemiology to outcomes

2020 ◽  
Vol 17 ◽  
Author(s):  
Shiling Chen ◽  
Chao Pan ◽  
Ping Zhang ◽  
Yingxin Tang ◽  
Zhouping Tang
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Neurological Complication ◽  
Pathophysiological Mechanism ◽  
C Reactive Protein ◽  
Vessel Occlusion ◽  
Reactive Protein ◽  
Detailed Search ◽  
Underlying Diseases ◽  
Worse Prognosis

Abstract:: Acute Ischemic Stroke (AIS) is currently the most frequently reported neurological complication of Coronavirus disease 2019 (COVID-19). This article will elaborate on the clinical features of inpatients with COVID-19 and AIS and the pathophysiological mechanism of AIS under the background of COVID-19. Through a detailed search of relevant studies, we found that the incidence of AIS among COVID-19 patients varied from 0.9% to 4.6%, and AIS has been observed in many people without underlying diseases and cardiovascular risk factors as well as young people. The National Institute of Health Stroke Scale (NIHSS) score of COVID-19 patients with AIS was higher than historical AIS patients, and the proportion of large vessel occlusion (LVO) was about 64.2%. COVID-19 patients with AIS have commonly high levels of D-D dimer, fibrinogen, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), suggesting systemic hyperinflammatory and hypercoagulable state. The pooled mortality of COVID-19 patients with AIS was 38% and the mortality of LVO patients is higher (45.9%). Compared with COVID-19-negative AIS patients in the same period in 2020 and 2019, COVID- 19 patients with AIS had a worse prognosis.

Risk factor control after ischemic stroke or transient ischemic attack

2021 ◽  
Author(s):  
Nanxiang Ouyang ◽  
Chuning Shi ◽  
Xiaofan Guo ◽  
Yihan Chen ◽  
Yingxian Sun
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Transient Ischemic Attack ◽  
Risk Factor Control ◽  
Ischemic Attack
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