A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments

2016 ◽  
Vol 28 (6) ◽  
pp. 803-810 ◽  
Author(s):  
Stephanie M. Greer ◽  
Andrea N. Goldstein ◽  
Brian Knutson ◽  
Matthew P. Walker
Keyword(s):  
Genetic Polymorphism ◽  
Sleep Deprivation ◽  
Dopamine Transporter ◽  
Sleep Loss ◽  
Functional Polymorphisms ◽  
Motivated Behavior ◽  
Brain Responses ◽  
Lack Of Sleep ◽  
Gains And Losses ◽  
The Impact

Despite an emerging link between alterations in motivated behavior and a lack of sleep, the impact of sleep deprivation on human brain mechanisms of reward and punishment remain largely unknown, as does the role of trait dopamine activity in modulating such effects in the mesolimbic system. Combining fMRI with an established incentive paradigm and individual genotyping, here, we test the hypothesis that trait differences in the human dopamine transporter (DAT) gene—associated with altered synaptic dopamine signalling—govern the impact of sleep deprivation on neural sensitivity to impending monetary gains and losses. Consistent with this framework, markedly different striatal reward responses were observed following sleep loss depending on the DAT functional polymorphisms. Only participants carrying a copy of the nine-repeat DAT allele—linked to higher phasic dopamine activity—expressed amplified striatal response during anticipation of monetary gain following sleep deprivation. Moreover, participants homozygous for the ten-repeat DAT allele—linked to lower phasic dopamine activity—selectively demonstrated an increase in sensitivity to monetary loss within anterior insula following sleep loss. Together, these data reveal a mechanistic dependency on human of trait dopaminergic function in determining the interaction between sleep deprivation and neural processing of rewards and punishments. Such findings have clinical implications in disorders where the DAT genetic polymorphism presents a known risk factor with comorbid sleep disruption, including attention hyperactive deficit disorder and substance abuse.

scholarly journals Does Sleep Promote False Memories?

2011 ◽  
Vol 23 (1) ◽  
pp. 26-40 ◽  
Author(s):  
Annabelle Darsaud ◽  
Hedwige Dehon ◽  
Olaf Lahl ◽  
Virginie Sterpenich ◽  
Mélanie Boly ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Memory Consolidation ◽  
Declarative Memory ◽  
False Memories ◽  
Retrosplenial Cortex ◽  
New Words ◽  
Brain Responses ◽  
Fmri Session ◽  
Significant Difference ◽  
Lack Of Sleep

Memory is constructive in nature so that it may sometimes lead to the retrieval of distorted or illusory information. Sleep facilitates accurate declarative memory consolidation but might also promote such memory distortions. We examined the influence of sleep and lack of sleep on the cerebral correlates of accurate and false recollections using fMRI. After encoding lists of semantically related word associates, half of the participants were allowed to sleep, whereas the others were totally sleep deprived on the first postencoding night. During a subsequent retest fMRI session taking place 3 days later, participants made recognition memory judgments about the previously studied associates, critical theme words (which had not been previously presented during encoding), and new words unrelated to the studied items. Sleep, relative to sleep deprivation, enhanced accurate and false recollections. No significant difference was observed in brain responses to false or illusory recollection between sleep and sleep deprivation conditions. However, after sleep but not after sleep deprivation (exclusive masking), accurate and illusory recollections were both associated with responses in the hippocampus and retrosplenial cortex. The data suggest that sleep does not selectively enhance illusory memories but rather tends to promote systems-level consolidation in hippocampo-neocortical circuits of memories subsequently associated with both accurate and illusory recollections. We further observed that during encoding, hippocampal responses were selectively larger for items subsequently accurately retrieved than for material leading to illusory memories. The data indicate that the early organization of memory during encoding is a major factor influencing subsequent production of accurate or false memories.

scholarly journals 493 An Examination into The Impact of Sleep Deprivation on Surgeons

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
V Antoniou ◽  
C C Booth ◽  
D Parry
Keyword(s):  
Sleep Deprivation ◽  
Health Care Professionals ◽  
Negative Impact ◽  
Sleep Habits ◽  
Deprivation Score ◽  
The United Kingdom ◽  
King's College ◽  
Lack Of Sleep ◽  
Short And Long Term ◽  
The Impact

Abstract Background Lack of sleep amongst surgeons is significant and worrying. It poses short- and long-term risks to surgeons’ health and negatively impacts patient outcomes. Previous studies have examined sleep deprivation amongst health care professionals. The aim of the present study was to examine impact in a specific population of surgical doctors. Method A questionnaire-based study completed in the anatomy department of King’s College London University. Surgical subjects spanned the United Kingdom. Subjects completed 14 questions regarding sleep habits. Data was compiled, calculating a sleep deprivation score. Results Valid responses were obtained from 66 surgical subjects of varying seniority. Mean age of subjects was 33.7 years old. 59.1% of subjects had rota commitments changing on a weekly basis. Average sleep amongst subjects amounted to 6.15 (± 1.26) hours per night. Daily sleep did not present differences dependent on seniority level (p = 0.186). 25.8% of subjects took >30 minutes to fall asleep. Our subjects woke 1.67 (± 1.21) times a night. Mean sleep deprivation score amongst our surgical population was 16.5 (± 4.26) demonstrating moderate negative impact on daily activities. 28.9% accumulated ≧20 sleep deprivation score demonstrating severe impact of sleep deprivation on life. Conclusions Our study has demonstrated reduced quantity and quality of sleep amongst our subject population. With protecting the health of both patients and surgeons in mind, we must place higher importance on improving sleep amongst surgical professionals.

scholarly journals Impact of total sleep deprivation and related mood changes on approach-avoidance decisions to threat-related facial displays

SLEEP ◽  
2021 ◽  
Author(s):  
Julie Grèzes ◽  
Mégane Erblang ◽  
Emma Vilarem ◽  
Michael Quiquempoix ◽  
Pascal Van Beers ◽  
...  
Keyword(s):  
Decision Making ◽  
Sleep Deprivation ◽  
Sustained Attention ◽  
Positive Mood ◽  
Sleep Loss ◽  
Total Sleep Deprivation ◽  
Mood Changes ◽  
Approach Avoidance ◽  
The Impact

Abstract Study Objectives Total sleep deprivation is known to have significant detrimental effects on cognitive and socio-emotional functioning. Nonetheless, the mechanisms by which total sleep loss disturbs decision-making in social contexts are poorly understood. Here, we investigated the impact of total sleep deprivation on approach/avoidance decisions when faced with threatening individuals, as well as the potential moderating role of sleep-related mood changes. Methods Participants (n = 34) made spontaneous approach/avoidance decisions in the presence of task-irrelevant angry or fearful individuals, while rested or totally sleep deprived (27 hours of continuous wakefulness). Sleep-related changes in mood and sustained attention were assessed using the Positive and Negative Affective Scale and the psychomotor vigilance task, respectively. Results Rested participants avoided both fearful and angry individuals, with stronger avoidance for angry individuals, in line with previous results. On the contrary, totally sleep deprived participants favored neither approach nor avoidance of fearful individuals, while they still comparably avoided angry individuals. Drift-diffusion models showed that this effect was accounted for by the fact that total sleep deprivation reduced value-based evidence accumulation toward avoidance during decision making. Finally, the reduction of positive mood after total sleep deprivation positively correlated with the reduction of fearful display avoidance. Importantly, this correlation was not mediated by a sleep-related reduction in sustained attention. Conclusions All together, these findings support the underestimated role of positive mood-state alterations caused by total sleep loss on approach/avoidance decisions when facing ambiguous socio-emotional displays, such as fear.

Adaptation of the 24-h growth hormone profile to a state of sleep debt

2000 ◽  
Vol 279 (3) ◽  
pp. R874-R883 ◽  
Author(s):  
K. Spiegel ◽  
R. Leproult ◽  
E. F. Colecchia ◽  
M. L'Hermite-Balériaux ◽  
Z. Nie ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Sleep Deprivation ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Sleep Loss ◽  
Gh Secretion ◽  
Hormone Profile ◽  
Sleep Debt ◽  
Normal Men ◽  
The Impact

In normal men, the majority of GH secretion occurs in a single large postsleep onset pulse that is suppressed during total sleep deprivation. We examined the impact of semichronic partial sleep loss, a highly prevalent condition, on the 24-h growth hormone profile. Eleven young men were studied after six nights of restricted bedtimes (0100–0500) and after 7 nights of extended bedtimes (2100–0900). Slow-wave sleep (SWS) was estimated as the duration of stages III and IV. Slow-wave activity (SWA) was calculated as electroencephalogram power density in the 0.5- to 3-Hz frequency range. During the state of sleep debt, the GH secretory pattern was biphasic, with both a presleep onset “circadian” pulse and a postsleep onset pulse. Postsleep onset GH secretion was negatively related to presleep onset secretion and tended to be positively correlated with the amount of concomitant SWA. When sleep was restricted, both SWS and SWA were increased during early sleep. Unexpectedly, the increase in SWA affected the second, rather than the first, SWA cycle, suggesting that presleep onset GH secretion may have limited SWA in the first cycle, possibly via an inhibition of central GH-releasing hormone activity. Thus neither the GH profile nor the distribution of SWA conformed with predictions from acute sleep deprivation studies, indicating that adaptation mechanisms are operative during chronic partial sleep loss.

scholarly journals Sleepless and Desynchronized: Impaired Inter Trial Phase Coherence of Steady-State Potentials Following Sleep Deprivation

2018 ◽  
Author(s):  
M Eidelman-Rothman ◽  
E Ben-Simon ◽  
D Freche ◽  
A Keil ◽  
T Hendler ◽  
...  
Keyword(s):  
Information Processing ◽  
Steady State ◽  
Sleep Deprivation ◽  
Event Related Potentials ◽  
Sleep Loss ◽  
Phase Coherence ◽  
Functional Impairments ◽  
Related Potentials ◽  
The Impact ◽  
Trial Phase

1.AbstractSleep loss has detrimental effects on cognitive and emotional functioning. These impairments have been associated with alterations in EEG measures of power spectrum and event-related potentials, however the impact of sleep loss on inter trial phase coherence (ITPC), a measure of phase consistency over experimental trials, remains mostly unknown. ITPC is thought to reflect the ability of the neural response to temporally synchronize with relevant events, thus optimizing information processing.In the current study we investigated the effects of sleep deprivation on information processing by evaluating the phase consistency of steady-state visual evoked potentials (ssVEPs) as well as amplitude-based measures of ssVEP, obtained from a group of 18 healthy individuals following 24 hours of total sleep deprivation and after a night of habitual sleep. An ssVEP task was utilized, which included the presentation of dots flickering at 7.5 Hz, along with a cognitive-emotional task. Our results show that ITPC is significantly reduced under sleep deprivation relative to habitual sleep. Interestingly, decreased ITPC under sleep deprivation was associated with decreased behavioral performance in the psychomotor vigilance task (PVT), a validate measure of reduced vigilance following lack of sleep.The results suggest that the capability of the brain to synchronize with rhythmic stimuli is disrupted without sleep. Thus, decreased ITPC may represent an objective and mechanistic measure of sleep loss, allowing future work to study the relation between brain-world synchrony and the specific functional impairments associated with sleep deprivation.

scholarly journals On-road driving impairment following sleep deprivation differs according to age

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna W. T. Cai ◽  
Jessica E. Manousakis ◽  
Bikram Singh ◽  
Jonny Kuo ◽  
Katherine J. Jeppe ◽  
...  
Keyword(s):  
Older Adults ◽  
Sleep Deprivation ◽  
Motor Vehicle ◽  
Sleep Loss ◽  
Driving Performance ◽  
Older Drivers ◽  
Younger Adults ◽  
Falling Asleep ◽  
Instrumented Vehicle ◽  
The Impact

AbstractImpaired driving performance due to sleep loss is a major contributor to motor-vehicle crashes, fatalities, and serious injuries. As on-road, fully-instrumented studies of drowsy driving have largely focused on young drivers, we examined the impact of sleep loss on driving performance and physiological drowsiness in both younger and older drivers of working age. Sixteen ‘younger’ adults (M = 24.3 ± 3.1 years [21–33 years], 9 males) and seventeen ‘older’ adults (M = 57.3 ± 5.2, [50–65 years], 9 males) undertook two 2 h drives on a closed-loop track in an instrumented vehicle with a qualified instructor following (i) 8 h sleep opportunity the night prior (well-rested), and (ii) after 29-h of total sleep deprivation (TSD). Following TSD, both age groups displayed increased subjective sleepiness and lane departures (p < 0.05), with younger drivers exhibiting 7.37 × more lane departures, and 11 × greater risk of near crash events following sleep loss. While older drivers exhibited a 3.5 × more lane departures following sleep loss (p = 0.008), they did not have a significant increase in near-crash events (3/34 drives). Compared to older adults, younger adults had 3.1 × more lane departures (p = < 0.001), and more near crash events (79% versus 21%, p = 0.007). Ocular measures of drowsiness, including blink duration, number of long eye closures and PERCLOS increased following sleep loss for younger adults only (p < 0.05). These results suggest that for older working-aged adults, driving impairments observed following sleep loss may not be due to falling asleep. Future work should examine whether this is attributed to other consequences of sleep loss, such as inattention or distraction from the road.

Comprehensive Income: which potential effects on firms' performance evaluation and users' decision process?

2016 ◽  
pp. 55-94
Author(s):  
Pier Luigi Marchini ◽  
Carlotta D'Este
Keyword(s):  
Performance Evaluation ◽  
Decision Process ◽  
Financial Analysts ◽  
Listed Companies ◽  
Financial Statement ◽  
Comprehensive Income ◽  
Other Comprehensive Income ◽  
Gains And Losses ◽  
The Impact

The reporting of comprehensive income is becoming increasingly important. After the introduction of Other Comprehensive Income (OCI) reporting, as required by the 2007 IAS 1-revised, the IASB is currently seeking inputs from investors on the usefulness of unrealized gains and losses and on the role of comprehensive income. This circumstance is of particular relevance in code law countries, as local pre-IFRS accounting models influence financial statement preparers and users. This study aims at investigating the role played by unrealized gains and losses reporting on users' decision process, by examining the impact of OCI on the Italian listed companies RoE ratio and by surveying a sample of financial analysts, also content analysing their formal reports. The results show that the reporting of comprehensive income does not affect the financial statement users' decision process, although it statistically affects Italian listed entities' performance.

scholarly journals Residual, differential neurobehavioral deficits linger after multiple recovery nights following chronic sleep restriction or acute total sleep deprivation

SLEEP ◽  
2020 ◽  
Author(s):  
Erika M Yamazaki ◽  
Caroline A Antler ◽  
Charlotte R Lasek ◽  
Namni Goel
Keyword(s):  
Sleep Deprivation ◽  
Response Speed ◽  
Sleep Loss ◽  
Sleep Restriction ◽  
Total Sleep Deprivation ◽  
Psychomotor Vigilance Test ◽  
Recovery Sleep ◽  
Time In Bed ◽  
Neurobehavioral Deficits ◽  
Chronic Sleep

Abstract Study Objectives The amount of recovery sleep needed to fully restore well-established neurobehavioral deficits from sleep loss remains unknown, as does whether the recovery pattern differs across measures after total sleep deprivation (TSD) and chronic sleep restriction (SR). Methods In total, 83 adults received two baseline nights (10–12-hour time in bed [TIB]) followed by five 4-hour TIB SR nights or 36-hour TSD and four recovery nights (R1–R4; 12-hour TIB). Neurobehavioral tests were completed every 2 hours during wakefulness and a Maintenance of Wakefulness Test measured physiological sleepiness. Polysomnography was collected on B2, R1, and R4 nights. Results TSD and SR produced significant deficits in cognitive performance, increases in self-reported sleepiness and fatigue, decreases in vigor, and increases in physiological sleepiness. Neurobehavioral recovery from SR occurred after R1 and was maintained for all measures except Psychomotor Vigilance Test (PVT) lapses and response speed, which failed to completely recover. Neurobehavioral recovery from TSD occurred after R1 and was maintained for all cognitive and self-reported measures, except for vigor. After TSD and SR, R1 recovery sleep was longer and of higher efficiency and better quality than R4 recovery sleep. Conclusions PVT impairments from SR failed to reverse completely; by contrast, vigor did not recover after TSD; all other deficits were reversed after sleep loss. These results suggest that TSD and SR induce sustained, differential biological, physiological, and/or neural changes, which remarkably are not reversed with chronic, long-duration recovery sleep. Our findings have critical implications for the population at large and for military and health professionals.

121 Behavioral Attention Relationships Vary Between Demographic Groups Across Sleep Loss and Recovery

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A49-A50
Author(s):  
Caroline Antler ◽  
Erika Yamazaki ◽  
Tess Brieva ◽  
Courtney Casale ◽  
Namni Goel
Keyword(s):  
Sleep Deprivation ◽  
Repeated Measures ◽  
Age Groups ◽  
Response Speed ◽  
Sleep Loss ◽  
Demographic Groups ◽  
Time In Bed ◽  
Median Split ◽  
The Relationship ◽  
High Bmi

Abstract Introduction The Psychomotor Vigilance Test (PVT) is a behavioral attention measure widely used to describe sleep loss deficits. Although there are reported differences in PVT performance for various demographic groups, no study has examined the relationship between measures on the 10-minute PVT (PVT10) and the 3-minute PVT (PVT3) within sex, age, and body mass index (BMI) groups throughout a highly controlled sleep deprivation study. Methods Forty-one healthy adults (mean±SD ages, 33.9±8.9y) participated in a 13-night experiment [2 baseline nights (10h-12h time in bed, TIB) followed by 5 sleep restriction (SR1-5) nights (4h TIB), 4 recovery nights (R1-R4; 12h TIB), and 36h total sleep deprivation (TSD)]. A neurobehavioral test battery, including the PVT10 and PVT3 was completed every 2h during wakefulness. Repeated measures correlation (rmcorr) compared PVT10 and PVT3 lapses (reaction time [RT] &gt;355ms [PVT3] and &gt;500ms [PVT10]) and response speed (1/RT) by examining correlations by day (e.g., baseline day 2) and time point (e.g., 1000h-2000h) within sex groups (18 females), within age groups defined by a median split (median=32, range=21-49y), and within BMI groups defined by a median split (median=25, range=17-31). Results PVT10 and PVT3 1/RT was significantly correlated at all study days and time points excluding at baseline for the younger group and at R2 for the higher BMI group. PVT10 and PVT3 lapses showed overall lower correlations across the study relative to 1/RT. Lapses were not significantly correlated at baseline for any group, for males across recovery (R1-R4), for the high BMI group at R2-R4, for the older group at R2-R3, or for the younger group at SR5 or R3. Conclusion Differentiating participants based on age, sex, or BMI revealed important variation in the relationship between PVT10 and PVT3 measures across the study. Surprisingly, lapses were not significantly correlated at baseline for any demographic group or across recovery for males or the high BMI or older group. Thus, PVT10 and PVT3 lapses may be less comparable in certain populations when well-rested. These findings add to a growing literature suggesting demographic factors may be important factors to consider when evaluating the effects of sleep loss. Support (if any) ONR Award N00014-11-1-0361;NIH UL1TR000003;NASA NNX14AN49G and 80NSSC20K0243; NIHR01DK117488

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