Resting-state Functional Connectivity of the Right Temporoparietal Junction Relates to Belief Updating and Reorienting during Spatial Attention

2020 ◽  
Vol 32 (6) ◽  
pp. 1130-1141
Author(s):  
Anne-Sophie Käsbauer ◽  
Paola Mengotti ◽  
Gereon R. Fink ◽  
Simone Vossel
Keyword(s):  
Functional Connectivity ◽  
Cognitive Processing ◽  
Resting State ◽  
Prior Information ◽  
Dependent Manner ◽  
Resting State Functional Connectivity ◽  
Belief Updating ◽  
Temporoparietal Junction ◽  
Right Temporoparietal Junction ◽  
The Right

Although multiple studies characterized the resting-state functional connectivity (rsFC) of the right temporoparietal junction (rTPJ), little is known about the link between rTPJ rsFC and cognitive functions. Given a putative involvement of rTPJ in both reorienting of attention and the updating of probabilistic beliefs, this study characterized the relationship between rsFC of rTPJ with dorsal and ventral attention systems and these two cognitive processes. Twenty-three healthy young participants performed a modified location-cueing paradigm with true and false prior information about the percentage of cue validity to assess belief updating and attentional reorienting. Resting-state fMRI was recorded before and after the task. Seed-based correlation analysis was employed, and correlations of each behavioral parameter with rsFC before the task, as well as with changes in rsFC after the task, were assessed in an ROI-based approach. Weaker rsFC between rTPJ and right intraparietal sulcus before the task was associated with relatively faster updating of the belief that the cue will be valid after false prior information. Moreover, relatively faster belief updating, as well as faster reorienting, were related to an increase in the interhemispheric rsFC between rTPJ and left TPJ after the task. These findings are in line with task-based connectivity studies on related attentional functions and extend results from stroke patients demonstrating the importance of interhemispheric parietal interactions for behavioral performance. The present results not only highlight the essential role of parietal rsFC for attentional functions but also suggest that cognitive processing during a task changes connectivity patterns in a performance-dependent manner.

scholarly journals Resting State Functional Connectivity Predicts Future Changes in Sedentary Behavior

2021 ◽  
Author(s):  
Timothy P. Morris ◽  
Aaron Kucyi ◽  
Sheeba Arnold Anteraper ◽  
Maiya Rachel Geddes ◽  
Alfonso Nieto-Castañon ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Exercise Intervention ◽  
Supplementary Motor Area ◽  
Anterior Insula ◽  
Motor Area ◽  
Anterior Cingulate ◽  
Sedentary Behaviors ◽  
Resting State Functional Connectivity ◽  
The Right

AbstractInformation about a person’s available energy resources is integrated in daily behavioral choices that weigh motor costs against expected rewards. It has been posited that humans have an innate attraction towards effort minimization and that executive control is required to overcome this prepotent disposition. With sedentary behaviors increasing at the cost of millions of dollars spent in health care and productivity losses due to physical inactivity-related deaths, understanding the predictors of sedentary behaviors will improve future intervention development and precision medicine approaches. In 64 healthy older adults participating in a 6-month aerobic exercise intervention, we use neuroimaging (resting state functional connectivity), baseline measures of executive function and accelerometer measures of time spent sedentary to predict future changes in objectively measured time spent sedentary in daily life. Using cross-validation and bootstrap resampling, our results demonstrate that functional connectivity between 1) the anterior cingulate cortex and the supplementary motor area and 2) the right anterior insula and the left temporoparietal/temporooccipital junction, predict changes in time spent sedentary, whereas baseline cognitive, behavioral and demographic measures do not. Previous research has shown activation in and between the anterior cingulate and supplementary motor area as well as in the right anterior insula during effort avoidance and tasks that integrate motor costs and reward benefits in effort-based decision making. Our results add important knowledge toward understanding mechanistic associations underlying complex sedentary behaviors.

scholarly journals Effects of long-term cocaine self-administration on brain resting-state functional connectivity in nonhuman primates

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Stephen J. Kohut ◽  
Dionyssios Mintzopoulos ◽  
Brian D. Kangas ◽  
Hannah Shields ◽  
Kelly Brown ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Processing ◽  
Resting State ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Resting State Functional Connectivity ◽  
Self Administration ◽  
Chronic Cocaine

AbstractLong-term cocaine use is associated with a variety of neural and behavioral deficits that impact daily function. This study was conducted to examine the effects of chronic cocaine self-administration on resting-state functional connectivity of the dorsal anterior cingulate (dACC) and putamen—two brain regions involved in cognitive function and motoric behavior—identified in a whole brain analysis. Six adult male squirrel monkeys self-administered cocaine (0.32 mg/kg/inj) over 140 sessions. Six additional monkeys that had not received any drug treatment for ~1.5 years served as drug-free controls. Resting-state fMRI imaging sessions at 9.4 Tesla were conducted under isoflurane anesthesia. Functional connectivity maps were derived using seed regions placed in the left dACC or putamen. Results show that cocaine maintained robust self-administration with an average total intake of 367 mg/kg (range: 299–424 mg/kg). In the cocaine group, functional connectivity between the dACC seed and regions primarily involved in motoric behavior was weaker, whereas connectivity between the dACC seed and areas implicated in reward and cognitive processing was stronger. In the putamen seed, weaker widespread connectivity was found between the putamen and other motor regions as well as with prefrontal areas that regulate higher-order executive function; stronger connectivity was found with reward-related regions. dACC connectivity was associated with total cocaine intake. These data indicate that functional connectivity between regions involved in motor, reward, and cognitive processing differed between subjects with recent histories of cocaine self-administration and controls; in dACC, connectivity appears to be related to cumulative cocaine dosage during chronic exposure.

scholarly journals Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Woo-Sung Kim ◽  
Guangfan Shen ◽  
Congcong Liu ◽  
Nam-In Kang ◽  
Keon-Hak Lee ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Negative Relationship ◽  
First Episode ◽  
Frontal Pole ◽  
Resting State Functional Connectivity ◽  
Significant Group ◽  
Attenuated Psychosis Syndrome ◽  
The Right ◽  
First Episode Schizophrenia

Abstract Altered resting-state functional connectivity (FC) of the amygdala (AMY) has been demonstrated to be implicated in schizophrenia (SZ) and attenuated psychosis syndrome (APS). Specifically, no prior work has investigated FC in individuals with APS using subregions of the AMY as seed regions of interest. The present study examined AMY subregion-based FC in individuals with APS and first-episode schizophrenia (FES) and healthy controls (HCs). The resting state FC maps of the three AMY subregions were computed and compared across the three groups. Correlation analysis was also performed to examine the relationship between the Z-values of regions showing significant group differences and symptom rating scores. Individuals with APS showed hyperconnectivity between the right centromedial AMY (CMA) and left frontal pole cortex (FPC) and between the laterobasal AMY and brain stem and right inferior lateral occipital cortex compared to HCs. Patients with FES showed hyperconnectivity between the right superficial AMY and left occipital pole cortex and between the left CMA and left thalamus compared to the APS and HCs respectively. A negative relationship was observed between the connectivity strength of the CMA with the FPC and negative-others score of the Brief Core Schema Scales in the APS group. We observed different altered FC with subregions of the AMY in individuals with APS and FES compared to HCs. These results shed light on the pathogenetic mechanisms underpinning the development of APS and SZ.

scholarly journals High-definition tDCS to the right temporoparietal junction modulates slow-wave resting state power and coherence in healthy adults

2019 ◽  
Vol 122 (4) ◽  
pp. 1735-1744 ◽  
Author(s):  
Peter H. Donaldson ◽  
Melissa Kirkovski ◽  
Joel S. Yang ◽  
Soukayna Bekkali ◽  
Peter G. Enticott
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Oscillatory Activity ◽  
High Definition ◽  
Temporoparietal Junction ◽  
Eyes Open ◽  
Right Temporoparietal Junction ◽  
The Right ◽  
Cathodal Stimulation

The right temporoparietal junction (rTPJ) is a multisensory integration hub that is increasingly utilized as a target of stimulation studies exploring its rich functional network roles and potential clinical applications. While transcranial direct current stimulation (tDCS) is frequently employed in such studies, there is still relatively little known regarding its local and network neurophysiological effects, particularly at important nonmotor sites such as the rTPJ. The current study applied either anodal, cathodal, or sham high-definition tDCS to the rTPJ of 53 healthy participants and used offline EEG to assess the impacts of stimulation on resting state (eyes open and eyes closed) band power and coherence. Temporoparietal and central region delta power was increased after anodal stimulation (the latter trend only), whereas cathodal stimulation increased frontal region delta and theta power. Increased coherence between right and left temporoparietal regions was also observed after anodal stimulation. All significant effects occurred in the eyes open condition. These findings are discussed with reference to domain general and mechanistic theories of rTPJ function. Low-frequency oscillatory activity may exert long-range inhibitory network influences that enable switching between and integration of endogenous/exogenous processing streams. NEW & NOTEWORTHY Through the novel use of high-definition transcranial direct current stimulation (tDCS) and EEG, we provide evidence that both anodal and cathodal stimulation of the right temporoparietal junction selectively modulate slow-wave power and coherence in distributed network regions of known relevance to proposed temporoparietal junction functionality. These results also provide direct evidence of the ability of tDCS to modulate oscillatory activity at a long-range network level, which may have explanatory power in terms of both neurophysiological and behavioral effects.

Altered habenula resting state functional connectivity in deprived veteran tobacco smokers: A pilot study

2020 ◽  
Vol 84 (1) ◽  
pp. 21-34
Author(s):  
Cassandra Jennings ◽  
Savannah Gosnell ◽  
Kaylah N. Curtis ◽  
Thomas Kosten ◽  
Ramiro Salas
Keyword(s):  
Pilot Study ◽  
Functional Connectivity ◽  
Tobacco Smoking ◽  
Resting State ◽  
Nicotine Withdrawal ◽  
Frontal Pole ◽  
Resting State Functional Connectivity ◽  
Tobacco Withdrawal ◽  
Lingual Gyrus ◽  
The Right

This study aimed to examine habenular resting state functional connectivity (RSFC) abnormalities in tobacco-smoking veterans. The authors explored RSFC in sated smokers (n = 3D 18), overnight deprived smokers (n = 3D 13), and nonsmoker controls (n = 3D 26). Seed-to-voxel analysis was used to explore RSFC in the habenula. Compared to sated smokers, deprived smokers demonstrated higher RSFC between the right habenula and two clusters of voxels: one in the right fusiform gyrus, and one in the left lingual gyrus. To study nicotine withdrawal, the authors used the Shiffman-Jarvik Withdrawal Questionnaire (SJWQ) score as a regressor and found higher RSFC between the right habenula and the left frontal pole in deprived compared to sated smokers. Right habenula RSFC distinguished between sated and deprived smokers and differentiated between sated and deprived smokers when using SJWQ as a regressor, suggesting a habenular role in tobacco withdrawal.

scholarly journals Resting-state functional connectivity, cortical GABA and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic imaging and resonance study

2018 ◽  
Author(s):  
Kristina M. Deligiannidis ◽  
Christina L. Fales ◽  
Aimee R. Kroll-Desrosiers ◽  
Scott A. Shaffer ◽  
Vanessa Villamarin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Neuroactive Steroids ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
Resting State Functional Connectivity ◽  
Magnetic Imaging ◽  
Temporal Pole ◽  
The Right ◽  
The Relationship

ABSTRACTPostpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unclear. We hypothesized that peripartum GABAergic neuroactive steroids (NAS) are related to cortical GABA concentrations and RSFC in PPD as compared to healthy comparison women (HCW). To test this, we measured RSFC with fMRI and GABA+/Creatine (Cr) concentrations with proton magnetic resonance spectroscopy (1H MRS) in the pregenual anterior cingulate (pgACC) and occipital cortices (OCC) and quantified peripartum plasma NAS. We examined between-group differences in RSFC and the relationship between cortical GABA+/Cr concentrations with RSFC. We investigated the relationship between NAS, RSFC and cortical GABA+/Cr concentrations. Within the default mode network (DMN) an area of the dorsomedial prefrontal cortex (DMPFC) had greater connectivity with the rest of the DMN in PPD (peak voxel: MNI coordinates (2, 58, 32), p=0.002) and was correlated to depression scores (peak HAM-D17 voxel: MNI coordinates (0, 60, 34), p=0.008). pgACC GABA+/Cr correlated positively with DMPFC RSFC in a region spanning the right anterior/posterior insula and right temporal pole (r=+0.661, p=0.000). OCC GABA+/Cr correlated positively with regions spanning both amygdalae (right amygdala: r=+0.522, p=0.000; left amygdala: r=+0.651, p=0.000) as well as superior parietal areas. Plasma allopregnanolone was higher in PPD (p=0.03) and positively correlated with intra DMPFC connectivity (r=+0.548, p=0.000) but not GABA+/Cr. These results provide initial evidence that PPD is associated with altered DMN connectivity; cortical GABA+/Cr concentrations are associated with postpartum RSFC and allopregnanolone is associated with postpartum intra-DMPFC connectivity.

scholarly journals An investigation of resting state functional connectivity of the anterior and posterior Hippocampal subregions in posttraumatic stress disorder and its relationship with symptoms

2021 ◽  
Author(s):  
Bailee L. Malivoire
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Functional Connectivity ◽  
Posttraumatic Stress ◽  
Resting State ◽  
Stress Disorder ◽  
Brain Regions ◽  
Imaging Biomarkers ◽  
Resting State Functional Connectivity ◽  
Hippocampal Activity ◽  
The Right

Posttraumatic stress disorder (PTSD) is associated with abnormal hippocampal activity; however, the functional connectivity (FC) of the hippocampus with other brain regions and its relations with symptoms warrants further attention. I investigated FC of the hippocampus at a subregional level in PTSD during a resting state compared to trauma exposed controls (TECs). Based on imaging literature in PTSD, I targeted the FCs of the hippocampal head and tail subregions with the amygdala, medial prefrontal cortex (mPFC), and the posterior cingulate (PCC). The PTSD group had significantly greater FC compared to the TEC group between the left hippocampal head and the right amygdala, and for the left hippocampal tail with bilateral PCC. Resting state FC predicted symptom severity at time of scan and 4-months post-scan. These results highlight abnormal illness-related FC with both the hippocampal head and tail and provide support for future investigations of imaging biomarkers predictive of disease progression.

scholarly journals An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus

2021 ◽  
Vol 11 (11) ◽  
pp. 1539
Author(s):  
Gianluca Cruciani ◽  
Maddalena Boccia ◽  
Vittorio Lingiardi ◽  
Guido Giovanardi ◽  
Pietro Zingaretti ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Functional Coupling ◽  
Brain Abnormalities ◽  
Resting State Functional Connectivity ◽  
Posterior Portion ◽  
The Right

Studies comparing organized (O) and unresolved/disorganized (UD) attachment have consistently shown structural and functional brain abnormalities, although whether and how attachment patterns may affect resting state functional connectivity (RSFC) is still little characterized. Here, we investigated RSFC of temporal and limbic regions of interest for UD attachment. Participants’ attachment was classified via the Adult Attachment Interview, and all participants underwent clinical assessment. Functional magnetic resonance imaging data were collected from 11 UD individuals and seven matched O participants during rest. A seed-to-voxel analysis was performed, including the anterior and the posterior cingulate cortex, the bilateral insula, amygdala and hippocampus as seed regions. No group differences in the clinical scales emerged. Compared to O, the UD group showed lower RSFC between the left amygdala and the left cerebellum (lobules VIII), and lower functional coupling between the right hippocampus and the posterior portion of the right middle temporal gyrus. Moreover, UD participants showed higher RSFC between the right amygdala and the anterior cingulate cortex. Our findings suggest RSFC alterations in regions associated with encoding of salient events, emotion processing, memories retrieval and self-referential processing in UD participants, highlighting the potential role of attachment experiences in shaping brain abnormalities also in non-clinical UD individuals.

scholarly journals Romantic jealousy is positively associated with fronto-striatal, insula and limbic responses to angry faces

2018 ◽  
Author(s):  
Xiaoxiao Zheng ◽  
Lizhu Luo ◽  
Jialin Li ◽  
Lei Xu ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Dorsal Striatum ◽  
Neural Representation ◽  
Resting State Functional Connectivity ◽  
Romantic Jealousy ◽  
The Right ◽  
Emotional Face ◽  
Emotional Responsivity

AbstractRomantic jealousy is a complex social emotion combining the different primary emotions of anger, fear and sadness. Previous evidence has suggested the involvement of fronto-striatal dopaminergic circuitry in clinical pathological jealousy, although little is known about overlaps with the neural representation of primary emotions involved in non-morbid jealousy. In the current study, 85 healthy subjects underwent fMRI during resting state and an emotional face recognition paradigm. A total of 150 faces (happy, angry, fearful, sad, neutral) were presented and subjects were required to identify the expression and rate its intensity. Trait romantic jealousy was assessed using the Multidimensional Jealousy Scale. Behavioral results showed that only intensity ratings of angry faces were positively associated with subjects’ jealousy scores. During processing of angry versus neutral expression faces, subjects with higher jealousy scores exhibited greater activation in the right thalamus, insula, fusiform gyrus and hippocampus, left dorsal striatum and superior parietal lobule and bilateral cerebellum and inferior frontal gyrus after controlling for trait aggression and sex. Functional connectivity between the inferior frontal gyrus and caudate was also increased. No associations with resting state functional connectivity were found. Overall, the present study demonstrates an association between romantic jealousy and increased intensity ratings of angry faces as well as in activity and functional connectivity of dorsal striatal-inferior frontal circuitry. Thus, increased emotional responsivity to social threat and enhanced activity in limbic regions and dopaminergic fronto-striatal circuitry may be features of both non-morbid and pathological jealousy.

Sign in / Sign up

Export Citation Format

Share Document