Simultaneous occurrence of polycythemia vera and Waldenstrom macroglobulinemia: A case report and review of the literature

Hypoalbuminemia has been reported as common in patients with symptomatic Waldenström macroglobulinemia (WM), but it is not typically mentioned as a manifestation of the disease in review articles or articles discussing indications for treatment. We present the case of a patient with WM for whom symptomatic hypoalbuminemia was the primary reason for initiating treatment. Except in rare cases of WM with renal or gastrointestinal involvement, hypoalbuminemia is thought to be due to the effects of elevated levels of inflammation-associated cytokines, and it has been associated with greater likelihood of progression of asymptomatic to symptomatic disease, greater disease severity, and poorer prognosis. Hypoalbuminemia in WM may become symptomatic, and it may be a reason to initiate treatment if symptoms affect quality of life.

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Management of Lytic Bone Disease in Lymphoplasmacytic Lymphoma: A Case Report and Review of the Literature

10.22541/au.162592069.98366479/v1 ◽

2021 ◽

Author(s):

Mizba Baksh ◽

Liuyan Jiang ◽

Unnati Bhatia ◽

Victoria Alegria ◽

Taimur Sher ◽

...

Keyword(s):

Case Report ◽

Bone Disease ◽

Bone Lesions ◽

Lymphoplasmacytic Lymphoma ◽

Review Of The Literature ◽

Waldenström Macroglobulinemia ◽

Waldenstrom Macroglobulinemia ◽

Lytic Bone Lesions

Waldenström Macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is often differentiated from myeloma based on the presence of lytic bone lesions (LBL). However, WM/LPL can present with LBL and management is poorly understood. We describe a case of an 81-year-old woman with LPL who presented with LBL and was successfully treated with chemoimmunotherapy.

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Neuropsychiatric Derangement by Polycythemia Vera: A Case Report of an Unexpected Disease Presentation and Review of the Literature

Acta Haematologica ◽

10.1159/000516441 ◽

2021 ◽

pp. 1-6

Author(s):

Heleen De Lil ◽

Michelle van Beek ◽

Alexandra Herbers ◽

Ellen van der Holst ◽

Karen Keijsers

Keyword(s):

Case Report ◽

Chronic Disease ◽

Cerebral Infarction ◽

Polycythemia Vera ◽

Neuropsychiatric Symptoms ◽

Unusual Presentation ◽

Review Of The Literature ◽

Remarkable Recovery ◽

Visual Complaints ◽

Underlying Pathophysiology

Cerebral infarction as well as other thromboses, headaches, and visual complaints are well-known symptoms of polycythemia vera. However, chorea and neuropsychiatric disturbances are less recognized consequences of this chronic disease. Whereas chorea is a rare but acknowledged symptom of polycythemia vera, neuropsychiatric symptoms have only sporadically been reported. We depict 2 patients with an unusual presentation of polycythemia vera. Our first patient presented with right-sided hemiballism and psychosis, and the second patient had a long diagnostic trajectory of unexplained chorea. In both cases diagnosis of JAK2 positive polycythemia vera was established, and in both cases remarkable recovery occurred after the initiation of phlebotomies. The underlying pathophysiology of these symptoms has not been clearly elucidated. Because of the unfamiliarity of the link between especially neuropsychiatric symptoms and polycythemia, current reported numbers are probably an underestimation. Benefit of treatment appears to be large. We seek to create more awareness among physicians about this phenomenon.

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Obinutuzumab in the treatment of a patient with Waldenström macroglobulinemia and rituximab intolerance – a case report

Transfuze a hematologie dnes ◽

10.48095/cctahd2021160 ◽

2021 ◽

Vol 27 (2) ◽

pp. 160-165

Author(s):

Zdeněk Adam ◽

Marta Krejčí ◽

Luděk Pour ◽

Martin Štork ◽

Viera Sandecká ◽

...

Keyword(s):

Case Report ◽

Waldenström Macroglobulinemia ◽

Waldenstrom Macroglobulinemia

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Agranulocytosis Associated with Waldenström Macroglobulinemia

Acta Haematologica ◽

10.1159/000489482 ◽

2018 ◽

Vol 140 (1) ◽

pp. 42-45 ◽

Cited By ~ 1

Author(s):

Iuliana Vaxman ◽

Daniel Shepshelovich ◽

Lucille Hayman ◽

Pia Raanani ◽

Meir Lahav

Keyword(s):

Case Report ◽

Febrile Neutropenia ◽

Medical History ◽

Case Reports ◽

Neutropenic Fever ◽

Severe Neutropenia ◽

Past Medical History ◽

Waldenström Macroglobulinemia ◽

Waldenstrom Macroglobulinemia ◽

History Of

Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. This is a case report of a woman with a past medical history of WM who presented with neutropenic fever. The patient’s febrile neutropenia resolved after RCD chemotherapy (cyclophosphamide 750 mg/m2, dexamethasone 20 mg, and rituximab 375 mg/m2). Fourteen days after administration, the neutrophil level had started to rise and normalized after 6 days. To the best of our knowledge, this is the 3rd reported case of agranulocytosis due to WM.

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Acquired Form of Angioedema of the Head and Neck Related to a Deficiency in C1-Inhibitor: A Case Report with a Review of the Literature

Case Reports in Otolaryngology ◽

10.1155/2012/405824 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Bassel Hallak ◽

Propser Konu ◽

Florian Lang ◽

Christian Simon ◽

Philippe Monnier

Keyword(s):

Case Report ◽

Mortality Rate ◽

Enzyme Inhibitor ◽

Laryngeal Edema ◽

Simultaneous Occurrence ◽

Inhibitor Protein ◽

C1 Inhibitor ◽

Review Of The Literature ◽

First Case ◽

Causative Factors

Angioedema related to a deficiency in the C1-inhibitor protein is characterized by its lack of response to therapies including antihistamine, steroids, and epinephrine. In the case of laryngeal edema, mortality rate is approximately 30 percent. The first case of the acquired form of angioedema related to a deficiency in C1-inhibitor was published in 1972. In our paper, we present a case of an acquired form of angioedema of the oropharyngeal region secondary to the simultaneous occurrence of two causative factors: neutralization of C1-inhibitor by an autoantibody and the use of an angiotensin convertin enzyme inhibitor.

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Polycythemia vera in childhood: Case report and review of the literature

American Journal of Hematology ◽

10.1002/ajh.2830090409 ◽

1980 ◽

Vol 9 (4) ◽

pp. 421-428 ◽

Cited By ~ 20

Author(s):

Elizabeth H. Danish ◽

Cleo A. Rasch ◽

John W. Harris

Keyword(s):

Case Report ◽

Polycythemia Vera ◽

Review Of The Literature

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Waldenstrom Macroglobulinemia and the Eye: A case report and review

Canadian Journal of Optometry ◽

10.15353/cjo.v83i3.1786 ◽

2021 ◽

Vol 83 (3) ◽

pp. 29-35

Author(s):

Mayur Bhavsar ◽

Joseph Cercone ◽

Catherine Chiu

Keyword(s):

Case Report ◽

B Cell ◽

Posterior Pole ◽

Monoclonal Protein ◽

Waldenström Macroglobulinemia ◽

Waldenstrom Macroglobulinemia ◽

Organ Systems ◽

Cell Disorder

Waldenstrom macroglobulinemia (WM) is a rare, malignant lymphoproliferative B-cell disorder causing an excessive buildup of monoclonal protein. WM is associated with excessive buildup of IgM, which can cause blood hyperviscosity and damage many organ systems. This case report describes a patient who was followed annually but rapidly developed posterior pole and significant midperipheral hemorrhages secondary to a hyperviscosity condition of the retina. Management of this condition is dependent on macular involvement and must be co-managed with an oncologist.

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