Risk Factors for the Onset of Transfusion Related Acute Lung Injury (TRALI) in Critically Ill Patients – A Retrospective Nested Case Control Study.

2009 ◽  
Author(s):  
AP Vlaar ◽  
JM Binnekade ◽  
D Prins ◽  
JJ Hofstra ◽  
MJ Schultz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Risk factors and outcome of transfusion-related acute lung injury in the critically ill: A nested case–control study*

2010 ◽  
Vol 38 (3) ◽  
pp. 771-778 ◽  
Author(s):  
Alexander P. J. Vlaar ◽  
Jan M. Binnekade ◽  
David Prins ◽  
Danielle van Stein ◽  
Jorrit J. Hofstra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Critically Ill ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Blood ◽  
2011 ◽  
Vol 117 (16) ◽  
pp. 4218-4225 ◽  
Author(s):  
Alexander P. J. Vlaar ◽  
Jorrit J. Hofstra ◽  
Rogier M. Determann ◽  
Denise P. Veelo ◽  
Frederique Paulus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Acute Lung Injury ◽  
Case Control Study ◽  
Case Control ◽  
Blood Products ◽  
Bioactive Lipids ◽  
Related Risk ◽  
Nested Case Control ◽  
Control Study

Abstract Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related morbidity and mortality. Both antibodies and bioactive lipids that have accumulated during storage of blood have been implicated in TRALI pathogenesis. In a single-center, nested, case-control study, patients were prospectively observed for onset of TRALI according to the consensus definition. Of 668 patients, 16 patients (2.4%) developed TRALI. Patient-related risk factors for onset of TRALI were age and time on the cardiopulmonary bypass. Transfusion-related risk factors were total amount of blood products (odds ratio [OR] = 1.2; 95% confidence interval [CI], 1.03-1.44), number of red blood cells stored more than 14 days (OR = 1.6; 95% CI, 1.04-2.37), total amount of plasma (OR = 1.2; 95% CI, 1.03-1.44), presence of antibodies in donor plasma (OR = 8.8; 95% CI, 1.8-44), and total amount of transfused bioactive lipids (OR = 1.0; 95% CI, 1.00-1.07). When adjusted for patient risk factors, only the presence of antibodies in the associated blood products remained a risk factor for TRALI (OR = 14.2; 95% CI, 1.5-132). In-hospital mortality of TRALI was 13% compared with 0% and 3% in transfused and nontransfused patients, respectively (P < .05). In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies.

scholarly journals Intraoperative ventilator settings and acute lung injury after elective surgery: a nested case control study

Thorax ◽  
2009 ◽  
Vol 64 (2) ◽  
pp. 121-127 ◽  
Author(s):  
E R Fernandez-Perez ◽  
J Sprung ◽  
B Afessa ◽  
D O Warner ◽  
C M Vachon ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Case Control Study ◽  
Elective Surgery ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study ◽  
Ventilator Settings

Impact of intravascular thrombosis on failure of radial arterial catheters in critically ill patients: a nested case-control study

2018 ◽  
Vol 44 (5) ◽  
pp. 553-563 ◽  
Author(s):  
Yvan Fleury ◽  
Diego Arroyo ◽  
Caroline Couchepin ◽  
Helia Robert-Ebadi ◽  
Marc Righini ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Case Control Study ◽  
Case Control ◽  
Intravascular Thrombosis ◽  
Nested Case Control ◽  
Control Study
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