Effect Of Vitamin D Deficiency In Critically Ill Patients

2012 ◽  
Author(s):  
Michael Agustin ◽  
Vera A. De Palo
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients

Relationship of Vitamin D Deficiency to Clinical Outcomes in Critically Ill Patients

2012 ◽  
Vol 36 (6) ◽  
pp. 713-720 ◽  
Author(s):  
David M. Higgins ◽  
Paul E. Wischmeyer ◽  
Kelly M. Queensland ◽  
Stefan H. Sillau ◽  
Alexandra J. Sufit ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Relationship Of

scholarly journals Vitamin D deficiency in critically ill patients with traumatic injuries

2016 ◽  
Vol 4 ◽  
pp. 1-9 ◽  
Author(s):  
Roland N. Dickerson ◽  
Jonathan R. Van Cleve ◽  
Joseph M. Swanson ◽  
George O. Maish ◽  
Gayle Minard ◽  
...  
Keyword(s):  
Vitamin D ◽  
African American ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Traumatic Injuries ◽  
Severe Deficiency ◽  
Severity Of Injury ◽  
25 Oh Vitamin D ◽  
African American Race

Abstract Background Vitamin D depletion has been associated with increased rate of infections, lengthened hospital stay, and worsened mortality for critically ill patients. The purpose of this study was to evaluate the prevalence and variables associated with vitamin D deficiency in critically ill patients with severe traumatic injuries. Methods Critically ill adult patients admitted to the trauma intensive care unit (ICU) between June 2013 and June 2014, referred to the nutrition support service for enteral or parenteral nutrition, and had a serum 25-hydroxyvitamin D (25-OH vitamin D) concentration determination were retrospectively evaluated. Patients were stratified as vitamin D sufficient, insufficient, deficient, or severely deficient based on a 25-OH vitamin D concentration of 30–80, 20–29.9, 13.1–19.9, and ≤13 ng/mL, respectively. Results One hundred and twenty-one patients out of 158 (76 %) patients were vitamin D deficient or severely deficient. Thirty-one patients (20 %) were insufficient and 6 (4 %) had a normal 25-OH vitamin D concentration. 25-OH vitamin D was determined 7.5 ± 5.1 days after ICU admission. African-Americans had a greater proportion of patients with deficiency or severe deficiency compared to other races (91 versus 64 %, P = 0.02). Penetrating gunshot or knife stab injury, African-American race, and obesity (elevated body mass index) were significantly associated with vitamin D deficiency or severe deficiency: OR 9.23 (1.13, 75.40), 4.0 (1.4, 11.58), and 1.12 (1.03, 1.23), P < 0.05, respectively. Conclusions The majority of critically ill patients with traumatic injuries exhibit vitamin D deficiency or severe deficiency. Penetrating injuries, African-American race, and obesity are significant risk factors for deficiency. Severity of injury, extent of inflammation (elevated C-reactive protein concentration), or hospital admission during the winter season did not significantly influence the prevalence of vitamin D deficiency.

Prevalence and Risk Factors of Vitamin D Deficiency in Critically Ill Patients

2013 ◽  
Vol 12 (4) ◽  
pp. 223-229 ◽  
Author(s):  
Bertrand Sauneuf ◽  
Jennifer Brunet ◽  
Olivier Lucidarme ◽  
Damien Cheyron
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients

Burden and Outcome of Vitamin D Deficiency Among Critically Ill Patients: A Prospective Study

2016 ◽  
Vol 32 (3) ◽  
pp. 378-384 ◽  
Author(s):  
Enas Anwar ◽  
Gehan Hamdy ◽  
Eman Taher ◽  
Esmat Fawzy ◽  
Sherif Abdulattif ◽  
...  
Keyword(s):  
Vitamin D ◽  
Prospective Study ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
A Prospective Study

Is vitamin D deficiency associated with development of Acinetobacter baumannii infections in critically ill patients?

2013 ◽  
Vol 28 (5) ◽  
pp. 735-740 ◽  
Author(s):  
Melda Türkoğlu ◽  
Gülbin Aygencel ◽  
Murat Dizbay ◽  
Ayşe Fitnat Tuncel ◽  
Burcu Arslan Candır ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acinetobacter Baumannii ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients

scholarly journals Up to 40% of COVID-19 Critically Ill Patients Have Vitamin D Deficiency

2020 ◽  
Author(s):  
Teresa-Maria Tomasa-Irriguible ◽  
Lara Bielsa-Berrocal
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Statistical Significance ◽  
Vitamin D Status ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Polymerase Chain ◽  
Potential Strategy

Background: Coronavirus disease (COVID-19) has caused more than 745,000 deaths worldwide. Vitamin D has been identified as a potential strategy to prevent or treat this disease. The purpose of the study was to measure vitamin D at hospital admission of COVID-19; Methods: We included critically ill patients with the polymerase chain reaction positive test for COVID-19, from March to April, 2020. Statistical significance was defined as P < .05. All tests were 2-tailed; Results: A total of 35 patients (median age, 60 years; 26 [74.3%] male) were included. Vitamin D levels were categorized as deficient for 14 participants (40%). Vitamin D deficiency was associated with vitamin A (P= 0.003) and Zinc (P= 0.019) deficiency and lower levels of albumin (P= 0.026) and prealbumin (P= 0.009). Overall, none of the studied variables were associated with vitamin D status: mortality, intensive care unit (ICU) or hospital stay, necessity of vasoactive agents, intubation, prone position, C reactive protein (CRP), Dimer-D, Interleukin 6 levels (IL-6), ferritin levels, or bacterial superinfection; Conclusions: In this single-center, retrospective cohort study, deficient vitamin D status was found in 40% in COVID-19 critically ill patients. However, deficient vitamin D status was not associated with inflammation or outcome.

scholarly journals Vitamin D status and its influence on outcomes following major burn injury and critical illness

2018 ◽  
Vol 6 ◽  
Author(s):  
Khaled Al-Tarrah ◽  
Martin Hewison ◽  
Naiem Moiemen ◽  
Janet M. Lord
Keyword(s):  
Vitamin D ◽  
Critical Illness ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Thermal Injury ◽  
Burn Injury ◽  
Vitamin D Supplementation ◽  
Burn Patients ◽  
Vitamin D Status

Abstract Vitamin D deficiency is common among the general population. It is also observed in up to 76% of critically ill patients. Despite the high prevalence of hypovitaminosis D in critical illness, vitamin D is often overlooked by medical staff as the clinical implications and consequences of vitamin D deficiency in acute contexts remain to be fully understood. Vitamin D has a broad range of pleotropic effects on various processes and systems including the immune-inflammatory response. 1α,25-dihydroxyvitamin D (1,25(OH)2D), has been shown to promote a tolerogenic immune response limiting deleterious inflammatory effects, modulation of the innate immune system, and enhancement of anti-microbial peptides. Vitamin D deficiency is frequently observed in critically ill patients and has been related to extrinsic causes (i.e., limited sunlight exposure), magnitude of injury/illness, or the treatment started by medical doctors including fluid resuscitation. Low levels of vitamin D in critically ill patients have been associated with sepsis, organ failure, and mortality. Despite this, there are subpopulations of critical illness, such as burn patients, where the literature regarding vitamin D status and its influence on outcomes remain insufficient. Thermal injury results in damage to both burned and non-burned tissues, as well as induces an exaggerated and persistent immune-inflammatory and hypermetabolic response. In this review, we propose potential mechanisms in which burn injury affects the vitamin D status and summarizes current literature investigating the influence of vitamin D status on outcomes. In addition, we reviewed the literature and trials investigating vitamin D supplementation in critically ill patients and discuss the therapeutic potential of vitamin D supplementation in burn and critically ill patients. We also highlight current limitations of studies that have investigated vitamin D status and supplementation in critical illness. Thermal injury influences vitamin D status. More studies investigating vitamin D depletion in burn patients and its influence on prognosis, via standardized methodology, are required to reach definitive conclusions and influence clinical practice.

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