Doxorubicin Loaded Silica Nanoparticles with Dual Modification as a Tumor-Targeted Drug Delivery System for Colon Cancer Therapy

2018 ◽  
Vol 18 (4) ◽  
pp. 2330-2336 ◽  
Author(s):  
Yong-Quan Lin ◽  
Jing Zhang ◽  
Shi-Jiang Liu ◽  
Hui Ye
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Cancer Therapy ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13673-13683 ◽  
Author(s):  
Luyao Wang ◽  
Mengke Qu ◽  
Shiqi Huang ◽  
Yu Fu ◽  
Liuqing Yang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
High Efficacy ◽  
Prostate Cancer Therapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The current work has designed a novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy using the pHCT74 peptide.

Targeted drug delivery system for oral cancer therapy using sonoporation

2009 ◽  
Vol 38 (7) ◽  
pp. 572-579 ◽  
Author(s):  
Hironobu Maeda ◽  
Kazuhiro Tominaga ◽  
Kenjiro Iwanaga ◽  
Fuminori Nagao ◽  
Manabu Habu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Oral Cancer ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

scholarly journals Folate-Functionalized Mesoporous Silica Nanoparticles as a Liver Tumor-Targeted Drug Delivery System to Improve the Antitumor Effect of Paclitaxel

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Xiaoyan Xu ◽  
Chao Wu ◽  
Andi Bai ◽  
Xuan Liu ◽  
Huiling Lv ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Drug ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared with pure PTX and mesoporous silica nanoparticles loaded with paclitaxel (MSNs-PTX). The biodistribution investigation of PTX in nude mice revealed that the FA-PEG-MSNs-PTX could accumulate in tumors. Folic acid functionalized MSNs resulted in a good targeting effect, confirming that FA-PEG-MSNs-PTX is a promising tumor-targeted drug delivery system for liver cancer chemotherapy.

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