Agreement Among Spectral-Domain Optical Coherence Tomography, Standard Automated Perimetry, and Stereophotography in the Detection of Glaucoma Progression

Objective. To evaluate the relationship between spectral-domain optical coherence tomography (OCT) and standard automated perimetry (SAP) in healthy and glaucoma individuals.Methods. The sample comprised 338 individuals divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent a reliable SAP and imaging of the optic nerve head with the Cirrus OCT. Pearson correlations were calculated between threshold sensitivity values of SAP (converted to linear scale) and OCT parameters.Results. Mean age did not differ between the control and glaucoma groups (59.55 ± 9.7 years and 61.05 ± 9.4 years, resp.;P=0.15). Significant differences were found for the threshold sensitivities at each of the 52 points evaluated with SAP (P<0.001) and the peripapillary retinal nerve fiber layer (RNFL) thicknesses, except at 3 and 9 clock-hour positions between both groups. Mild to moderate correlations (ranging between 0.286 and 0.593;P<0.001) were observed between SAP and most OCT parameters in the glaucoma group. The strongest correlations were found between the inferior RNFL thickness and the superior hemifield points. The healthy group showed lower and weaker correlations than the glaucoma group.Conclusions. Peripapillary RNFL thickness measured with Cirrus OCT showed mild to moderate correlations with SAP in glaucoma patients.

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A Comparison Among Microperimetry, Standard Automated Perimetry and Spectral Domain Optical Coherence Tomography in the Evaluation of the Macula in Glaucoma Eyes with Hemifield Defects

Ophthalmology and Therapy ◽

10.1007/s40123-021-00423-5 ◽

2021 ◽

Author(s):

Tian Tian ◽

Yu Cai ◽

Mei Li ◽

Yuan Fang ◽

Yingzi Pan

Keyword(s):

Optical Coherence Tomography ◽

Spectral Domain ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry

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Comparing Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry to Diagnose Glaucomatous Optic Neuropathy

Journal of Glaucoma ◽

10.1097/ijg.0000000000000048 ◽

2015 ◽

Vol 24 (5) ◽

pp. e69-e74 ◽

Cited By ~ 4

Author(s):

Harsha L. Rao ◽

Ravi K. Yadav ◽

Uday K. Addepalli ◽

Viquar U. Begum ◽

Sirisha Senthil ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Neuropathy ◽

Spectral Domain ◽

Glaucomatous Optic Neuropathy ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry

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Structure-Function Modeling of Optical Coherence Tomography and Standard Automated Perimetry in the Retina of Patients with Autosomal Dominant Retinitis Pigmentosa

PLoS ONE ◽

10.1371/journal.pone.0148022 ◽

2016 ◽

Vol 11 (2) ◽

pp. e0148022 ◽

Cited By ~ 24

Author(s):

Travis B. Smith ◽

Maria Parker ◽

Peter N. Steinkamp ◽

Richard G. Weleber ◽

Ning Smith ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinitis Pigmentosa ◽

Structure Function ◽

Autosomal Dominant ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

Autosomal Dominant Retinitis Pigmentosa

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Оptical coherence tomography and optical coherence tomography-angiography in determining the progression of glaucoma

POINT OF VIEW EAST – WEST ◽

10.25276/2410-1257-2021-1-26-31 ◽

2021 ◽

pp. 26-31

Author(s):

N.I. Kurysheva ◽

◽

A.D. Nikitina ◽

Keyword(s):

Optical Coherence Tomography ◽

Functional Assessment ◽

Oct Angiography ◽

Ganglion Cell Complex ◽

Automated Perimetry ◽

Optical Coherence ◽

Complex Dynamic ◽

Glaucoma Progression ◽

Primary Glaucoma ◽

Sd Oct

Purpose. To study the role of optical coherence tomography (OCT) and OCT angiography (OCTA) in the detection of the primary glaucoma progression. Material and methods. The prospective study of 128 patients with primary glaucoma (128 eyes), conducted from 2015 to 2019, included at least 6 standard automated perimetry (SAP) and spectral-domain OCT (SD-OCT) examinations in each patient; OCTA was also used during the last year of observation. To determine the disease progression, the trend and event analysis using the Humphrey Field Analyzer was performed. The fact and rate of thinning of the retinal nerve fiber layer (RNFL) and its ganglion cell complex (GCC) were evaluated. If they had a trend of significant (p < 0.05) thinning, the eye was classified as having the SD-OCT progression. The values of corneal-compensated IOP were also considered: minimal (IOPmin) and peak (IOPmax). Results. Glaucoma progression was detected in 79 eyes. The isolated use of SAP allows detecting the progression only in 2.3% cases, SD-OCT - in 37.5%, among them the isolated assessment of GCC amounted to 7.8%, and RNFL – to 5.5%. The complex dynamic morphological and functional assessment increased the possibility of progression detection up to 61.7%. Progression was related to the stage of glaucoma damage at the moment of diagnosis: for the perimetry index PSD p=0.025, for the focal loss volume of GCC p=0.024, as well as with the level of minimal IOP (p=0.04). All patients with progression have shown the vessel density decrease in the peripapillary retina and parafovea. Conclusion. SD-OCT plays an important role in detecting the progression of glaucoma. The complex dynamic morphological and functional assessment allows detecting the progression in over half of patients. Progression is associated with the initial stage of glaucoma and an insufficient IOP decrease during treatment, accompanied by retinal microcirculation deterioration. Key words: primary, glaucoma progression, optical coherence tomography, OCT-angiography, IOP.

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Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1177/1352458509359782 ◽

2010 ◽

Vol 16 (4) ◽

pp. 412-426 ◽

Cited By ~ 32

Author(s):

Michal Laron ◽

Han Cheng ◽

Bin Zhang ◽

Jade S Schiffman ◽

Rosa A Tang ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Mean Deviation ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

Fiber Layer ◽

Field Of Vision ◽

Multiple Sclerosis Patients ◽

Visual Evoked

Background: Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision. Objective: To compare the sensitivity of mfVEP, Humphrey visual field (HVF) and optical coherence tomography (OCT) in detecting visual abnormality in multiple sclerosis (MS) patients. Methods: mfVEP, HVF, and OCT (retinal nerve fiber layer [RNFL]) were performed in 47 MS-ON eyes (last optic neuritis [ON] attack ≥6 months prior) and 65 MS-no-ON eyes without ON history. Criteria to define an eye as abnormal were: (1) mfVEP amplitude/latency — either amplitude or latency probability plots meeting cluster criteria with 95% specificity; (2) mfVEP amplitude or latency alone (specificity: 97% and 98%, respectively); and (3) HVF and OCT, mean deviation and RNFL thickness meeting p < 0.05, respectively. Results: MfVEP (amplitude/latency) identified more abnormality in MS-ON eyes (89%) than HVF (72%), OCT (62%), mfVEP amplitude (66%) or latency (67%) alone. Eighteen percent of MS-no-ON eyes were abnormal for both mfVEP (amplitude/latency) and HVF compared with 8% with OCT. Agreement between tests ranged from 60% to 79%. mfVEP (amplitude/latency) categorized an additional 15% of MS-ON eyes as abnormal compared with HVF and OCT combined. Conclusions: mfVEP, which detects both demyelination (increased latency) and neural degeneration (reduced amplitude), revealed more abnormality than HVF or OCT in MS patients.

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