scholarly journals Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa.

1994 ◽  
Vol 93 (4) ◽  
pp. 1439-1450 ◽  
Author(s):  
J P Liu ◽  
I J Clarke ◽  
J W Funder ◽  
D Engler
Keyword(s):  
Anorexia Nervosa ◽  
Neuropeptide Y ◽  
Arginine Vasopressin ◽  
Endogenous Depression ◽  
Corticotropin Releasing Factor ◽  
Portal Circulation ◽  
Hypothalamic Pituitary Adrenal ◽  
Activation Potential ◽  
Conscious Sheep ◽  
Hypophysial Portal

Studies of the Secretion of Corticotropin-Releasing Factor and Arginine Vasopressin into the Hypophysial-Portal Circulation of the Conscious Sheep

1989 ◽  
Vol 49 (4) ◽  
pp. 367-381 ◽  
Author(s):  
Dennis Engler ◽  
Thao Pham ◽  
Meryl J. Fullerton ◽  
Guck Ooi ◽  
John W. Funder ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Corticotropin Releasing Factor ◽  
Portal Circulation ◽  
Conscious Sheep ◽  
Hypophysial Portal

scholarly journals Effect of endotoxin on the hypothalamic-pituitary-adrenal axis in sheep

1998 ◽  
pp. 193-197 ◽  
Author(s):  
F Dadoun ◽  
V Guillaume ◽  
N Sauze ◽  
J Farisse ◽  
JG Velut ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Cortisol Secretion ◽  
Corticotropin Releasing Hormone ◽  
Hypothalamic Pituitary Adrenal ◽  
Initial Transient ◽  
Physiological Conditions ◽  
Adrenal Axis ◽  
Hypothalamic Level ◽  
Pituitary Adrenal Axis ◽  
Hypophysial Portal

Endotoxin has been shown to stimulate ACTH and cortisol secretion through an action at the hypothalamic level. However, the nature of hypothalamic neurohormones, corticotropin-releasing hormone (CRH) and especially arginine vasopressin (AVP), involved in that regulation is still controversial. The purpose of this study was to determine the effects of an acute i.v. endotoxin administration on CRH and AVP secretion into hypophysial portal blood (HPB). The experiment has been performed in sheep since it is possible to collect HPB and quantify CRH and AVP secretion in this animal under physiological conditions. The release of both peptides into HPB was stimulated by endotoxin injection, the increase in portal AVP being more pronounced than that of CRH. An initial, transient, increase in jugular AVP concentrations was observed, probably due to the activation of magnocellular AVP neurons. In conclusion, our data indicate that the activation of the pituitary-adrenal axis after endotoxin injection is associated with an increased release of both CRH and AVP into HPB. Magnocellular AVP neurons are initially stimulated while parvocellular CRH and AVP neurons are stimulated throughout the experiment.

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