scholarly journals Phenotypic and functional changes in peripheral blood monocytes during progression of human immunodeficiency virus infection. Effects of soluble immune complexes, cytokines, subcellular particulates from apoptotic cells, and HIV-1-encoded proteins on monocytes phagocytic function, oxidative burst, transendothelial migration, and cell surface phenotype.

1995 ◽  
Vol 95 (4) ◽  
pp. 1690-1701 ◽  
Author(s):  
J Trial ◽  
H H Birdsall ◽  
J A Hallum ◽  
M L Crane ◽  
M C Rodriguez-Barradas ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Phagocytic Function ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Functional Changes ◽  
Immunodeficiency Virus ◽  
Soluble Immune Complexes ◽  
Hiv 1

scholarly journals Dendritic Cell Precursors Are Permissive to Dengue Virus and Human Immunodeficiency Virus Infection

2005 ◽  
Vol 79 (12) ◽  
pp. 7291-7299 ◽  
Author(s):  
Wing-Hong Kwan ◽  
Anna-Marija Helt ◽  
Concepción Marañón ◽  
Jean-Baptiste Barbaroux ◽  
Anne Hosmalin ◽  
...  
Keyword(s):  
Immune Response ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Dengue Virus ◽  
Blood Monocytes ◽  
Dengue Virus Infection ◽  
Differentiation Potential ◽  
Antiviral Immune Response ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT CD14+ interstitial cells reside beneath the epidermis of skin and mucosal tissue and may therefore play an important role in viral infections and the shaping of an antiviral immune response. However, in contrast to dendritic cells (DC) or blood monocytes, these antigen-presenting cells (APC) have not been well studied. We have previously described long-lived CD14+ cells generated from CD34+ hematopoietic progenitors, which may represent model cells for interstitial CD14+ APC. Here, we show that these cells carry DC-SIGN and differentiate into immature DC in the presence of granulocyte-macrophage colony-stimulating factor. We have compared the CD14+ cells and the DC derived from these cells with respect to dengue virus and human immunodeficiency virus type 1 (HIV-1) infection. Both cell types are permissive to dengue virus infection, but the CD14+ cells secrete the anti-inflammatory cytokine interleukin 10 and no tumor necrosis factor alpha. Regarding HIV, the CD14+ cells are permissive to HIV-1, release higher p24 levels than the derived DC, and more efficiently activate HIV Pol-specific CD8+ memory T cells. The CD14+ DC precursors infected with either virus retain their DC differentiation potential. The results suggest that interstitial CD14+ APC may contribute to HIV-1 and dengue virus infection and the shaping of an antiviral immune response.

A clinically relevant HIV-1 subunit vaccine protects rhesus macaques from in vivo passaged simian–human immunodeficiency virus infection

AIDS ◽  
1998 ◽  
Vol 12 (5) ◽  
pp. F15-F22 ◽  
Author(s):  
Petra Mooij ◽  
Mike van der Kolk ◽  
Willy M.J.M. Bogers ◽  
Peter J.F. ten Haaft ◽  
Peter Van Der Meide ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Subunit Vaccine ◽  
Rhesus Macaques ◽  
Immunodeficiency Virus ◽  
Hiv 1

DELAYED RECOGNITION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN PREADOLESCENT CHILDREN

PEDIATRICS ◽  
1994 ◽  
Vol 94 (2) ◽  
pp. 273-273
Author(s):  
George McAnelly ◽  
William T. Shearer
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Incubation Period ◽  
Free State ◽  
Older Children ◽  
Immunodeficiency Virus ◽  
Delayed Recognition ◽  
Disease Free ◽  
Hiv 1

The incubation period for perinatally or neonatally acquired HIV-1 infection in children may be quite variable. This study demonstrated how a prolonged disease-free state and underlying immune abnormalities may exist in older children with HIV-1 infection. Physicians caring for children must have a heightened awareness that HIV-1 infection may appear in the older child.

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