scholarly journals NTRK- and RET-fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake

2021 ◽  
Author(s):  
Young Ah Lee ◽  
Hyunjung Lee ◽  
Sun-Wha Im ◽  
Young Shin Song ◽  
Do-Youn Oh ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Tumor Response ◽  
Radioiodine Uptake ◽  
Pediatric Thyroid Cancer

scholarly journals Simulation of Post-Thyroidectomy Treatment Alternatives for Triiodothyronine or Thyroxine Replacement in Pediatric Thyroid Cancer Patients

Thyroid ◽  
2012 ◽  
Vol 22 (6) ◽  
pp. 595-603 ◽  
Author(s):  
Rotem Ben-Shachar ◽  
Marisa Eisenberg ◽  
Stephen A. Huang ◽  
Joseph J. DiStefano
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Thyroxine Replacement ◽  
Treatment Alternatives ◽  
Pediatric Thyroid Cancer

scholarly journals Expression and function of the novel proto-oncogene PBF in thyroid cancer: a new target for augmenting radioiodine uptake

2011 ◽  
Vol 210 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Vicki E Smith ◽  
Jayne A Franklyn ◽  
Christopher J McCabe
Keyword(s):  
Thyroid Cancer ◽  
Current Data ◽  
Subcellular Localisation ◽  
Sodium Iodide Symporter ◽  
Iodide Uptake ◽  
Radioiodine Uptake ◽  
Novel Target ◽  
And Function

Pituitary tumor-transforming gene (PTTG)-binding factor (PBF; PTTG1IP) was initially identified through its interaction with the human securin, PTTG. Like PTTG, PBF is upregulated in multiple endocrine tumours including thyroid cancer. PBF is believed to induce the translocation of PTTG into the cell nucleus where it can drive tumourigenesis via a number of different mechanisms. However, an independent transforming ability has been demonstrated both in vitro and in vivo, suggesting that PBF is itself a proto-oncogene. Studied in only a limited number of publications to date, PBF is emerging as a protein with a growing repertoire of roles. Recent data suggest that PBF possesses a complex multifunctionality in an increasing number of tumour settings. For example, PBF is upregulated by oestrogen and mediates oestrogen-stimulated cell invasion in breast cancer cells. In addition to a possible role in the induction of thyroid tumourigenesis, PBF overexpression in thyroid cancers inhibits iodide uptake. PBF has been shown to repress sodium iodide symporter (NIS) activity by transcriptional regulation of NIS expression through the human NIS upstream enhancer and further inhibits iodide uptake via a post-translational mechanism of NIS governing subcellular localisation. This review discusses the current data describing PBF expression and function in thyroid cancer and highlights PBF as a novel target for improving radioiodine uptake and thus prognosis in thyroid cancer.

Clinical Analysis of Pediatric Thyroid Cancer: A Single Medical Institution Experience of 18 Years

2019 ◽  
Vol 128 (12) ◽  
pp. 1152-1157 ◽  
Author(s):  
Hyung Kwon Byeon ◽  
Sang Bin Kim ◽  
Hyeon Seok Oh ◽  
Hong Kyu Kim ◽  
In Hak Choi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Medical Center ◽  
Disease Recurrence ◽  
Clinical Analysis ◽  
Lateral Lymph Node ◽  
Node Metastasis ◽  
Pediatric Thyroid Cancer

Objective: The incidence of pediatric thyroid cancer is relatively low compared to the disease in adults. This study aims to present the data in our institution on pediatric thyroid cancer patients, with particular emphasis on the risk factors of recurrence together with treatment outcomes. Subjects and Methods: Between January 2000 and July 2018, patients <20 years who were diagnosed with thyroid carcinoma and primarily treated with surgery at a major large-volume tertiary medical center specializing in thyroid cancer were enrolled. A total of 83 patients were eligible for this study. Results: The majority of the studied patients were girls and adolescents (age ≥13 years). Papillary thyroid carcinoma (PTC) was the most common pathology (n = 74). PTC tumors >1 cm showed higher rate of lymph node metastasis and extrathyroidal extension than tumors ≤1 cm. All patients survived with nine PTC patients who displayed treatment failure. Age, tumor size, multifocality, lateral lymph node metastasis, and postoperative thyroglobulin levels were significant prognosticators for disease recurrence. Conclusion: Pediatric thyroid cancer is relatively rare and should be considered a specific disease entity with respect to the thyroid cancer in adults, since there are several distinctive characteristics.

A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer

2016 ◽  
Vol 142 (5) ◽  
pp. 472 ◽  
Author(s):  
Zaid Al-Qurayshi ◽  
Adam Hauch ◽  
Sudesh Srivastav ◽  
Rizwan Aslam ◽  
Paul Friedlander ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
National Perspective ◽  
Pediatric Thyroid Cancer

Cytoplasmic Localization of the Paired Box Gene, Pax-8, is Found in Pediatric Thyroid Cancer and May Be Associated With a Greater Risk of Recurrence

Thyroid ◽  
2004 ◽  
Vol 14 (12) ◽  
pp. 1037-1046 ◽  
Author(s):  
William T. Scouten ◽  
Aneeta Patel ◽  
Richard Terrell ◽  
Henry B. Burch ◽  
Victor J. Bernet ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cytoplasmic Localization ◽  
Risk Of Recurrence ◽  
Pediatric Thyroid Cancer

Pediatric Thyroid Cancer

2017 ◽  
pp. 125-133
Author(s):  
Melanie Goldfarb ◽  
Trevan Fischer
Keyword(s):  
Thyroid Cancer ◽  
Pediatric Thyroid Cancer

scholarly journals Thyroid Cancer in the Pediatric Population

Genes ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 723 ◽  
Author(s):  
Vera A. Paulson ◽  
Erin R. Rudzinski ◽  
Douglas S. Hawkins
Keyword(s):  
Thyroid Cancer ◽  
Pediatric Population ◽  
Medullary Carcinoma ◽  
High Rate ◽  
Molecular Characteristics ◽  
Thyroid Tumors ◽  
Molecular Alterations ◽  
Stage Disease ◽  
Therapeutic Recommendations ◽  
Pediatric Thyroid Cancer

Thyroid cancer is rare in the pediatric population, but thyroid carcinomas occurring in children carry a unique set of clinical, pathologic, and molecular characteristics. In comparison to adults, children more often present with aggressive, advanced stage disease. This is at least in part due to the underlying biologic and molecular differences between pediatric and adult thyroid cancer. Specifically, papillary thyroid carcinoma (which accounts for approximately 90% of pediatric thyroid cancer) has a high rate of gene fusions which influence the histologic subtypes encountered in pediatric thyroid tumors, are associated with more extensive extrathyroidal disease, and offer unique options for targeted medical therapies. Differences are also seen in pediatric follicular thyroid cancer, although there are few studies of non-papillary pediatric thyroid tumors published in the literature due to their rarity, and in medullary carcinoma, which is most frequently diagnosed in the pediatric population in the setting of prophylactic thyroidectomies for known multiple endocrine neoplasia syndromes. The overall shift in the spectrum of histotypes and underlying molecular alterations common in pediatric thyroid cancer is important to recognize as it may directly influence diagnostic test selection and therapeutic recommendations.

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