Increasing Placebo Response in Antipsychotic Drug Trials: Let’s Stop the Vicious Circle

2013 ◽  
Vol 170 (11) ◽  
pp. 1232-1234 ◽  
Author(s):  
Stefan Leucht ◽  
Stephan Heres ◽  
John M. Davis
Keyword(s):  
Antipsychotic Drug ◽  
Placebo Response ◽  
Vicious Circle ◽  
Drug Trials

scholarly journals Disconnection of drug-response and placebo-response in acute-phase antipsychotic drug trials on schizophrenia? Meta-regression analysis

2019 ◽  
Vol 44 (11) ◽  
pp. 1955-1966 ◽  
Author(s):  
Stefan Leucht ◽  
Anna Chaimani ◽  
Dimitris Mavridis ◽  
Claudia Leucht ◽  
Maximilian Huhn ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Antipsychotic Drug ◽  
Acute Phase ◽  
Drug Response ◽  
Placebo Response ◽  
Drug Trials ◽  
Meta Regression ◽  
Meta Regression Analysis

scholarly journals 60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Meta-regression of predictors of placebo response

2018 ◽  
Vol 201 ◽  
pp. 315-323 ◽  
Author(s):  
Stefan Leucht ◽  
Anna Chaimani ◽  
Claudia Leucht ◽  
Maximilian Huhn ◽  
Dimitris Mavridis ◽  
...  
Keyword(s):  
Antipsychotic Drug ◽  
Placebo Response ◽  
Drug Trials ◽  
Acute Schizophrenia ◽  
Meta Regression

Placebo response in antidepressant drug trials

1994 ◽  
Vol 9 (3) ◽  
pp. 115-118 ◽  
Author(s):  
M Beneke ◽  
W Rasmus ◽  
J Fritze
Keyword(s):  
Frequency Analysis ◽  
Low Dose ◽  
Antidepressant Drug ◽  
Placebo Response ◽  
Response Patterns ◽  
Relative Efficacy ◽  
Drug Trials ◽  
Double Blind ◽  
Pooled Data ◽  
Blind Trials

SummaryResponse patterns derived from dichotomized (0/1) weekly CGI ratings conducted in antidepressant drug trials (Quitkin et al, 1984) were compared with those found in the pooled data from several randomized double-blind trials comparing the relative efficacy and tolerability low-dose flupenthixol im with that of three trieyclics (amitriptyline sr, imipramine, doxepine). Using the configurational frequency analysis (Krauth and Lienert, 1973), the postulated patterns could be rediscovered in our data apart from “early onset persistent patterns” which were less frequent in Quitkin et al's (1984) drug data. However, apart from this finding no “typical” patterns in terms of drug- or placebo-dependent response patterns could be detected in either the flupenthixol or Quitkin et al's (1984) data. It is concluded that there is little empirical evidence for the assumption of placebo- or drug related change- or response patterns. Moreover, theoretical aspects do not support the usefulness of such concepts.

Pretrial Medication Bias in Randomized Antipsychotic Drug Trials

2007 ◽  
Vol 164 (8) ◽  
pp. 1266-1266 ◽  
Author(s):  
STEFAN LEUCHT ◽  
STEPHAN HERES ◽  
JOHANNES HAMANN ◽  
WERNER KISSLING
Keyword(s):  
Antipsychotic Drug ◽  
Drug Trials

scholarly journals Mood Predicts Response to Placebo CPAP

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Carl J. Stepnowsky ◽  
Wei-Chung Mao ◽  
Wayne A. Bardwell ◽  
José S. Loredo ◽  
Joel E. Dimsdale
Keyword(s):  
Positive Airway Pressure ◽  
Placebo Response ◽  
Hierarchical Regression ◽  
Apnea Hypopnea Index ◽  
Drug Trials ◽  
Factors Associated ◽  
Beneficial Effects ◽  
Cpap Treatment ◽  
Total Mood Disturbance ◽  
Obstructive Sleep

Study Objectives. Continuous positive airway pressure (CPAP) therapy is efficacious for treating obstructive sleep apnea (OSA), but recent studies with placebo CPAP (CPAP administered at subtherapeutic pressure) have revealed nonspecific (or placebo) responses to CPAP treatment. This study examined baseline psychological factors associated with beneficial effects from placebo CPAP treatment.Participants. Twenty-five participants were studied with polysomnography at baseline and after treatment with placebo CPAP.Design. Participants were randomized to either CPAP treatment or placebo CPAP. Baseline mood was assessed with the Profile of Mood States (POMS). Total mood disturbance (POMS-Total) was obtained by summing the six POMS subscale scores, with Vigor weighted negatively. The dependent variable was changed in apnea-hypopnea index (ΔAHI), calculated by subtracting pre- from post-CPAP AHI. Negative values implied improvement. Hierarchical regression analysis was performed, with pre-CPAP AHI added as a covariate to control for baseline OSA severity.Results. Baseline emotional distress predicted the drop in AHI in response to placebo CPAP. Highly distressed patients showed greater placebo response, with a 34% drop (i.e., improvement) in AHI.Conclusion. These findings underscore the importance of placebo-controlled studies of CPAP treatment. Whereas such trials are routinely included in drug trials, this paper argues for their importance even in mechanical-oriented sleep interventions.

Measuring Movement Disorders in Antipsychotic Drug Trials

2007 ◽  
Vol 27 (5) ◽  
pp. 423-430 ◽  
Author(s):  
Anton J.M. Loonen ◽  
Herman M. van Praag
Keyword(s):  
Antipsychotic Drug ◽  
Movement Disorders ◽  
Drug Trials
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