scholarly journals Comparative Efficacy and Acceptability of 21 Antidepressant Drugs for the Acute Treatment of Adults With Major Depressive Disorder: A Systematic Review and Network Meta-Analysis

2018 ◽  
Vol 16 (4) ◽  
pp. 420-429 ◽  
Author(s):  
Andrea Cipriani ◽  
Toshi A Furukawa ◽  
Georgia Salanti ◽  
Anna Chaimani ◽  
Lauren Z Atkinson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Acute Treatment ◽  
Meta Analysis ◽  
Antidepressant Drugs ◽  
Comparative Efficacy ◽  
Major Depressive

scholarly journals Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis

BMJ ◽  
2021 ◽  
pp. n532
Author(s):  
Jennifer A Watt ◽  
Zahra Goodarzi ◽  
Areti Angeliki Veroniki ◽  
Vera Nincic ◽  
Paul A Khan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Meta Analysis ◽  
Cognitive Stimulation ◽  
Comparative Efficacy ◽  
Major Depressive ◽  
Symptoms Of Depression ◽  
People With Dementia ◽  
Drug Interventions

Abstract Objective To describe the comparative efficacy of drug and non-drug interventions for reducing symptoms of depression in people with dementia who experience depression as a neuropsychiatric symptom of dementia or have a diagnosis of a major depressive disorder. Design Systematic review and meta-analysis. Data sources Medline, Embase, the Cochrane Library, CINAHL, PsycINFO, and grey literature between inception and 15 October 2020. Eligibility criteria for study selection Randomised trials comparing drug or non-drug interventions with usual care or any other intervention targeting symptoms of depression in people with dementia. Main outcome measures Pairs of reviewers screened studies, abstracted aggregate level data, and appraised risk of bias with the Cochrane risk of bias tool, which facilitated the derivation of standardised mean differences and back transformed mean differences (on the Cornell scale for depression in dementia) from bayesian random effects network meta-analyses and pairwise meta-analyses. Results Of 22 138 citations screened, 256 studies (28 483 people with dementia) were included. Missing data posed the greatest risk to review findings. In the network meta-analysis of studies including people with dementia without a diagnosis of a major depressive disorder who were experiencing symptoms of depression (213 studies; 25 177 people with dementia; between study variance 0.23), seven interventions were associated with a greater reduction in symptoms of depression compared with usual care: cognitive stimulation (mean difference −2.93, 95% credible interval −4.35 to −1.52), cognitive stimulation combined with a cholinesterase inhibitor (−11.39, −18.38 to −3.93), massage and touch therapy (−9.03, −12.28 to −5.88), multidisciplinary care (−1.98, −3.80 to −0.16), occupational therapy (−2.59, −4.70 to −0.40), exercise combined with social interaction and cognitive stimulation (−12.37, −19.01 to −5.36), and reminiscence therapy (−2.30, −3.68 to −0.93). Except for massage and touch therapy, cognitive stimulation combined with a cholinesterase inhibitor, and cognitive stimulation combined with exercise and social interaction, which were more efficacious than some drug interventions, no statistically significant difference was found in the comparative efficacy of drug and non-drug interventions for reducing symptoms of depression in people with dementia without a diagnosis of a major depressive disorder. Clinical and methodological heterogeneity precluded network meta-analysis of studies comparing the efficacy of interventions specifically for reducing symptoms of depression in people with dementia and a major depressive disorder (22 studies; 1829 patients). Conclusions In this systematic review, non-drug interventions were found to be more efficacious than drug interventions for reducing symptoms of depression in people with dementia without a major depressive disorder. Systematic review registration PROSPERO CRD42017050130.

Escitalopram versus duloxetine in acute treatment of major depressive disorder: a meta-analysis and systematic review

2017 ◽  
Vol 27 ◽  
pp. S859-S860 ◽  
Author(s):  
B. Maneeton ◽  
N. Maneeton ◽  
P. Woottiluk ◽  
S. Likhitsathian ◽  
V. Boonyanaruthee ◽  
...  
Keyword(s):  
Systematic Review ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Acute Treatment ◽  
Meta Analysis ◽  
Major Depressive

scholarly journals Escitalopram vs duloxetine in acute treatment of major depressive disorder: meta-analysis and systematic review

2018 ◽  
Vol Volume 14 ◽  
pp. 1953-1961
Author(s):  
Benchalak Maneeton ◽  
Narong Maneeton ◽  
Surinporn Likhitsathian ◽  
Pakapan Woottiluk ◽  
Punjaree Wiriyacosol ◽  
...  
Keyword(s):  
Systematic Review ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Acute Treatment ◽  
Meta Analysis ◽  
Major Depressive
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