scholarly journals Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies

2009 ◽  
Vol 88 (10) ◽  
pp. 894-903 ◽  
Author(s):  
O. Grundmann ◽  
G.C. Mitchell ◽  
K.H. Limesand
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Salivary Gland ◽  
Animal Models ◽  
Salivary Glands ◽  
Clinical Implications ◽  
Future Directions ◽  
Radiation Induced ◽  
Secondary Side

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

Radiation Induced Xerostomia: Current Concepts and Future Trends

2017 ◽  
Vol 2 (3) ◽  
pp. 256 ◽  
Author(s):  
Manu Krishnan ◽  
Satish R Iyer ◽  
Kanti Lal Chakraborti ◽  
Saraswathy Seema ◽  
Tarun Sekhri
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Salivary Gland ◽  
Head And Neck ◽  
Neck Cancer ◽  
Current Knowledge ◽  
Intensity Modulated Radiotherapy ◽  
Chemical Derivatives ◽  
Radiation Induced

Radiation induced xerostomia is a persistent clinical presentation that affects the quality of life in head and neck cancer patients even with the best of the intensity modulated radiotherapy protocols. Comprehensive review of the anatomic, histologic, developmental and neuronal entities of salivary glands from a regenerative perspective, ensuing radiation is taken. It also evaluates the systemic and glandular radiation responses that form the early and late clinical changes. From these, the article submits probable strategies; based on the current knowledge and future challenges involved, in reversing radiation induced xerostomia. Further, it elaborates on the status of radioprotectors and mitigators including the recently reported biologic and chemical derivatives and proposes the rationale of using combination radioprotector therapy in radiation injuries. A brief of palliative regimes, alternate treatment modes and technologic advancements in radiotherapy are also explained. Salivary gland histologic components, which need to be protected in the emerging radiotherapy protocols and can be targeted in different salivary gland regeneration therapies is highlighted. The paper contributes to an improved understanding in radiation induced xerostomia and deliberates on novel mechanisms towards enhancing quality of life in head and neck cancer radiotherapy patients.

Radiation-induced Xerostomia in patients with head and neck cancer: Pathogenesis, impact on quality of life, and management

Head & Neck ◽  
2004 ◽  
Vol 26 (9) ◽  
pp. 796-807 ◽  
Author(s):  
Mark S. Chambers ◽  
Adam S. Garden ◽  
Merrill S. Kies ◽  
Jack W. Martin
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Pathogenesis ◽  
Radiation Induced

Quality of life and outcomes research in head and neck cancer: A review of the state of the discipline and likely future directions

2009 ◽  
Vol 35 (5) ◽  
pp. 397-402 ◽  
Author(s):  
Suhail I. Sayed ◽  
B. Elmiyeh ◽  
Peter Rhys-Evans ◽  
Konstantinos N. Syrigos ◽  
Chris M. Nutting ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Outcomes Research ◽  
The State ◽  
Future Directions

scholarly journals aImpact of radiation-induced toxicities on quality of life of patients treated for head and neck cancer

2021 ◽  
Author(s):  
Hans Paul van der Laan ◽  
Lisa Van den Bosch ◽  
Ewoud Schuit ◽  
Roel J.H.M. Steenbakkers ◽  
Arjen van der Schaaf ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Radiation Induced
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