An Approach to Pain in Research Animals

1988 ◽  
Vol 16 (2) ◽  
pp. 145-154
Author(s):  
David B. Adams
Keyword(s):  
Tissue Damage ◽  
Effective Means ◽  
Physical Pain ◽  
Insufficient Information ◽  
Experimental Procedure ◽  
Analgesic Drugs ◽  
Diagnosis And Prognosis ◽  
Experimental Subjects ◽  
Decisive Action ◽  
Cause Of Pain

Pain can either signal the threat of tissue-damage (nociception) or can result from tissue damage itself. The physiology and “pathology” of pain, in the second instance, suggest that it can be diagnosed (not “measured”, “assessed”, etc.) on the basis of its association, but not equality, with tissue damage and by its coincidence with changes in behaviour. Pain will be present as part of a syndrome and cannot occur without cause or association. Pain may occur in experiments: a) coincidentally and unrelated to any experimental procedure, b) accidentally, when a procedure goes amiss, and c) as part of the experimental design. Where pain is intrinsic to the aims of an experiment (for example in the testing of analgesics), “escape routes” and “limits” must be formulated for the benefit of experimental subjects. In addition, the empirical value of the experiment must be assessed. There is insufficient information on the use and efficacy of analgesic drugs in animals. These drugs, however, are neither the only nor the most effective means of alleviating physical pain in animals. Other forms of treatment are considered. All depend on sound diagnosis and prognosis. Decisive action against the cause of pain is necessary.

Motor Evoked Potentials

2009 ◽  
pp. 385-398
Author(s):  
Jeffrey A. Strommen
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Motor Evoked Potentials ◽  
Effective Means ◽  
Clinical Settings ◽  
Motor Pathways ◽  
Diagnosis And Prognosis ◽  
Cord Injury ◽  
Nerve Recordings ◽  
Peripheral Motor

MEP recordings are a safe and effective means of assessing conduction along the central and peripheral motor pathways in a variety of clinical settings. MEP is proven to be effective in monitoring central motor pathways that are at risk during surgical procedures and is finding usefulness in the diagnosis and prognosis of several central nervous system disorders such as multiple sclerosis, stroke, and spinal cord injury. The responses can be elicited by a variety of stimulation techniques using either magnetic or electrical stimulation to the cortex, spinal cord, or peripheral nerve. Recordings can be obtained from several structures including the spinal cord, peripheral nerve, or muscle dependent on the clinical application. The clinical neurophysiologist should have a basic understanding of the techniques as well as the potential physiologic and technical factors that need to be accounted for in the interpretation of these studies.

Basic pain terms in Beserman Udmurt

2021 ◽  
pp. 69
Author(s):  
Maria Usacheva
Keyword(s):  
Close Contact ◽  
Body Part ◽  
The Body ◽  
Semantic Structure ◽  
Physical Pain ◽  
Grammatical Encoding ◽  
Turkic Languages ◽  
Level I ◽  
Syntactic Properties ◽  
Cause Of Pain

This paper is devoted to semantic structure and syntactic properties of predicates of pain in Beserman Udmurt. Beserman is a variety of Udmurt spoken in northwestern Udmurtia, which has undergone contact infl uence of Russian dialects and of Turkic languages. We analyze meanings and compatibility of units which denote pain, describe grammatical encoding of diff erent participants of the situation of pain — the experiencer, the body part where pain is located, and the cause of pain. We consider the following parameters to be relevant for encoding the situation of pain in Beserman Udmurt: type of experiencer, location of pain and its cause (including a human making someone feel pain), pure pain vs. pain accompanied by functionality loss, physical pain vs. painful emotions, intensity of pain and its type. We compare Beserman Udmurt data with those from idioms which either are closely related to Udmurt genetically or are in the situation of close contact with it — namely, with the data from Komi-Zyrian, certain Russian dialects, and Turkic languages. We show that unlike Komi-Zyrian, its relative, Beserman Udmurt encodes diff erent types of pain on the lexical level (i. e. by verbal roots and ideophones), not on the grammatical one (i. e. through morphological derivation). In this respect, Beserman Udmurt resembles certain Turkic languages. The diversity of argument encoding in expressions of pain is a common trait of Beserman Udmurt and Komi-Zyrian; it seems to be supported by the infl uence of Russian dialects.

Of Rats and Economists

2003 ◽  
Vol 25 (4) ◽  
pp. 397-411 ◽  
Author(s):  
Terrence McDonough
Keyword(s):  
Lever Press ◽  
American Economic Review ◽  
Experimental Chamber ◽  
Laboratory Setting ◽  
Liquid Food ◽  
Food Ration ◽  
Experimental Procedure ◽  
White Rats ◽  
Experimental Subjects ◽  
Giffen Good

When the article “Experimental Confirmation of the Existence of a Giffen Good,” authored by Raymond C. Battalio, John H. Kagel, and Carl A. Kogut, appeared in 1991 in the American Economic Review it represented the culmination of two separate and seemingly unrelated traditions in the economics literature. The first is a now-venerable tradition of attempting to locate Giffen behavior in the real world. The second is a more truncated modern tradition of animal experimentation in economics. In their article, Battalio et al. combine these traditions through setting out to discover Giffen behavior in a laboratory setting using white rats as experimental subjects. The authors (p. 962) describe their experimental procedure:Subjects were placed in an experimental chamber for approximately three hours each day, during which time they received their entire daily liquid food ration … A rat obtained quinine and root beer by pressing either of two levers mounted on a wall in the experimental chamber … Income was controlled by restricting the number of lever presses that would result in obtaining liquid. Prices were changed by varying the amount of liquid obtained at each lever press.

An Ultrastructural Study of Chronic Pyelonephritis in Macaca Arctoides

1976 ◽  
Vol 34 ◽  
pp. 310-311
Author(s):  
T.W. Smith ◽  
J.A. Roberts ◽  
B.J. Martin
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Ultrastructural Study ◽  
Effective Means ◽  
Chronic Pyelonephritis ◽  
Macaca Arctoides ◽  
Left Ureter ◽  
E Coli ◽  
Transmission Electron ◽  
Sizeable Number

Chronic pyelonephritis is one of the most common diseases of the kidney and accounts for a sizeable number of cases of renal insufficiency in man, however its pathogenesis requires further elucidation. Transmission electron microscopy may serve as a uniquely effective means of observing details of the nature of this disease. The present paper describes preliminary results of an ultrastructural study of chronic pyelonephritis in Macaca arctoides (stumptail monkey).The infection was induced in these experiments in a retrograde fashion by means of a unilateral catheterization of the left ureter whereby an innoculum of 10 cc of broth containing approximately 2 billion E. coli per cc and radio-opaque dye were injected under pressure (mimicing vesico-ureteric reflux).

Artifacts caused by dehydration and epoxy embedding in TEM

1991 ◽  
Vol 49 ◽  
pp. 338-339
Author(s):  
Hilton H. Mollenhauer
Keyword(s):  
Electron Microscopy ◽  
Electron Beam ◽  
Volume Change ◽  
Tissue Damage ◽  
Beam Specimen ◽  
Chemical Fixation ◽  
Resin Impregnation ◽  
Storage Vesicles ◽  
A Cell ◽  
Tissue Shrinkage

Various means have been devised to preserve biological specimens for electron microscopy, the most common being chemical fixation followed by dehydration and resin impregnation. It is intuitive, and has been amply demonstrated, that these manipulations lead to aberrations of many tissue elements. This report deals with three parts of this problem: specimen dehydration, epoxy embedding resins, and electron beam-specimen interactions. However, because of limited space, only a few points can be summarized.Dehydration: Tissue damage, or at least some molecular transitions within the tissue, must occur during passage of a cell or tissue to a nonaqueous state. Most obvious, perhaps, is a loss of lipid, both that which is in the form of storage vesicles and that associated with tissue elements, particularly membranes. Loss of water during dehydration may also lead to tissue shrinkage of 5-70% (volume change) depending on the tissue and dehydrating agent.

Ultrastructure and analytical microprobe analysis of simian lung mite pigments

1986 ◽  
Vol 44 ◽  
pp. 324-325
Author(s):  
R. W. Cole ◽  
J. C. Kim
Keyword(s):  
Biomedical Research ◽  
Tissue Damage ◽  
Microprobe Analysis ◽  
Old World Monkeys ◽  
Old World ◽  
Experimental Animals ◽  
The Past ◽  
Lung Mite ◽  
Mite Infestations ◽  
Cardiopulmonary System

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.

Morphologic differences between abdominal and inguinal testes in stallions

1987 ◽  
Vol 45 ◽  
pp. 820-821
Author(s):  
F. Al-Bagdadi ◽  
D. Hoyt ◽  
P. Karns ◽  
G. Martin ◽  
M. Memon ◽  
...  
Keyword(s):  
Carcinoma Cells ◽  
Genital System ◽  
Diagnosis And Prognosis ◽  
Male Genital System ◽  
Morphological Differences ◽  
Hormone Imbalance ◽  
Made In ◽  
Male Genital

The most frequently occuring abnormality of the male genital system in mammals is the failure of one or both testes to descend into the scrotum. The reasons for abdominal or inguinal retention of testes could be anatomic malformation, faulty development or hormone imbalance.Cryptorchidism has been associated with either greatly reduced or absent spermatogenesis (Kaueakami et al, 1984), and being a source of neoplasia. According to Stick (1980), germinal carcinoma cells have been believed to be the cause of teratomas in equine cryptorchid testicles. Neoplasia has been reported in descended testes of unilateral cryptorchid patients (Martin et al, 1981).No distinction has been made in relating the problem of cryptorchid testes to inguinal or abdominal retention. The purpose of this study is to record the morphological differences between inguinal and abdominal cryptorchid testes as an aid in diagnosis and prognosis.

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Benefits and Characteristics of Mentoring Students and Young Professionals

2008 ◽  
Vol 18 (2) ◽  
pp. 67-73 ◽  
Author(s):  
Kristal Mills
Keyword(s):  
Leadership Development ◽  
Clinical Supervision ◽  
Effective Means ◽  
Academic Research ◽  
Mentoring Programs ◽  
Teaching Skills ◽  
Online Mentoring ◽  
Young Professionals ◽  
Research And Teaching ◽  
Workplace Retention

Abstract Mentoring has long been believed to be an effective means of developing students' clinical, research, and teaching skills to become competent professionals. The American Speech-Language-Hearing Association (ASHA) has developed two online mentoring programs, Student to Empowered Professional (S.T.E.P. 1:1) and Mentoring Academic Research Careers (MARC), to aid in the development of students. This paper provides a review of the literature on mentoring and compares and contrasts mentoring/mentors with clinical supervision/preceptors. Characteristics of effective mentors and mentees are offered. Additionally, the benefits of clinical mentoring such as, teambuilding in the workplace, retention of new staff, leadership development, and improved job satisfaction are discussed.

Articulatory Behavior Pre and Post Full-Mouth Tooth Extraction and Alveoloplasty

1980 ◽  
Vol 23 (3) ◽  
pp. 630-645 ◽  
Author(s):  
Gerald Zimmermann ◽  
J.A. Scott Kelso ◽  
Larry Lander
Keyword(s):  
Control Subject ◽  
High Speed ◽  
Tooth Extraction ◽  
Kinematic Parameters ◽  
Experimental Conditions ◽  
Mean Values ◽  
Articulatory Movements ◽  
The Mean ◽  
Experimental Subjects ◽  
Normal Speech

High speed cinefluorography was used to track articulatory movements preceding and following full-mouth tooth extraction and alveoloplasty in two subjects. Films also were made of a control subject on two separate days. The purpose of the study was to determine the effects of dramatically altering the structural dimensions of the oral cavity on the kinematic parameters of speech. The results showed that the experimental subjects performed differently pre and postoperatively though the changes were in different directions for the two subjects. Differences in both means and variabilities of kinematic parameters were larger between days for the experimental (operated) subjects than for the control subject. The results for the Control subject also showed significant differences in the mean values of kinematic variables between days though these day-to-day differences could not account for the effects found pre- and postoperatively. The results of the kinematic analysis, particularly the finding that transition time was most stable over the experimental conditions for the operated subjects, are used to speculate about the coordination of normal speech.

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