Glomerular Filtration Rate Estimated after Multiple Injections of Contrast Medium during Angiography

1988 ◽  
Vol 29 (6) ◽  
pp. 669-674 ◽  
Author(s):  
M. Boijsen ◽  
G. Granerus ◽  
L. Jacobsson ◽  
L. Björneld ◽  
M. Aurell ◽  
...  
Keyword(s):  
Renal Failure ◽  
Contrast Medium ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Single Injection ◽  
Fluorescence Analysis ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
X Ray ◽  
Multiple Injections

In twenty-six patients referred for angiography, clearance of contrast medium was determined with x-ray fluorescence analysis after multiple injections of contrast medium. A formula for correction of the injected amount, which takes into consideration the different times of contrast medium injections, approximating the total injected amount into one injection, was used. A single injection clearance of 51Cr-EDTA was determined at the same time. The results showed a good correlation between the clearance of contrast medium after multiple injections and the 51Cr-EDTA clearance after a single injection (r=0.945). The correlation between contrast medium clearance calculated without correction for the different injection times, and “Cr-EDTA clearance was the same (r=0.946), due to short angiography time and rather low clearance values in our patients. It is concluded that total plasma clearance of contrast medium can easily be estimated after multiple injections. In this way patients with a risk of developing post-angiographic renal failure can be found.

Simultaneous Urography and Determination of Glomerular Filtration Rate

1994 ◽  
Vol 35 (4) ◽  
pp. 391-395 ◽  
Author(s):  
S. Lundqvist ◽  
S.-O. Hietala ◽  
C. Berglund ◽  
K. Karp
Keyword(s):  
Contrast Medium ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Patient Comfort ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
X Ray ◽  
Multiple Sample ◽  
Fluorescence Analyzer

The total plasma clearance of iohexol at urography and 51Cr-EDTA was compared in 31 patients with di- or tetraparesis. A reference 51Cr-EDTA clearance was also performed 24 hours prior to the urography. The GFR was calculated from one, 2 or 4 plasma samples collected 180, 210, 240 and 270 min after the injection. An X-ray fluorescence analyzer was used for the analysis of iohexol in plasma as well as the contrast medium clearance calculations. It was shown that single or multiple sample clearance of iohexol and 51Cr-EDTA were equivalent methods for measurement of the GFR. The GFR was not affected by iohexol in a dose routinely used for urography. It was concluded that the patient comfort is improved if 51Cr-EDTA clearance is replaced by contrast medium clearance in association with urography.

Renal Function Measured by X-ray Fluorescence Analysis

1987 ◽  
Vol 28 (5) ◽  
pp. 581-585 ◽  
Author(s):  
M. Boijsen ◽  
L. Jacobsson ◽  
U. Tylén
Keyword(s):  
Contrast Medium ◽  
Plasma Clearance ◽  
Total Error ◽  
Fluorescence Analysis ◽  
Iodine Concentration ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
Transient Change ◽  
X Ray ◽  
Medium Dose

In twenty-six patients injected with metrizoate during urography, plasma was analyzed for iodine concentration using x-ray fluorescence analysis, and total plasma clearance of contrast medium was calculated. Total plasma clearance of 51Cr-EDTA was also determined, but not simultaneously, in order to find out if the urographic procedure would influence the kidneys to such an extent that the contrast medium clearance value would differ much from the 51Cr-EDTA clearance value. The errors in the method were assessed and the total error of the contrast medium clearance determination was calculated. When comparing 51Cr-EDTA and metrizoate clearance a correlation of 0.94 and a mean ratio of 1.046 (SD 0.138) was found. The assessable errors cannot fully explain the standard deviation, which might indicate a transient change in kidney function related to elements of the urographic procedure such as laxation with possible dehydration and/or the contrast medium dose.

Experimental Studies Comparing Iohexol and 51Cr-Edta for Glomerular Filtration Rate Measurements

1995 ◽  
Vol 36 (1) ◽  
pp. 58-63 ◽  
Author(s):  
S. Lundqvist ◽  
S.-O. Hietala ◽  
K. Karp
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Renal Clearance ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Experimental Studies ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
51Cr Edta

The total plasma clearance as well as the renal clearance of iohexol were evaluated for determination of the glomerular filtration rate (GFR) in 16 anesthetized pigs. The iohexol levels in urine and plasma were measured by X-ray fluorescence. The total plasma clearance of 1 and 4 ml/kg b.w. of iohexol 300 mg I/ml was compared to the simultaneously as well as nonsimultaneously calculated total plasma clearance of 51Cr-EDTA. The total plasma clearance of 51Cr-EDTA and of iohexol turned out to be equal and independent of the injected dose of iohexol. The injected dose did not have any effect on the renal clearance of iohexol either. It is concluded that iohexol and 51Cr-EDTA are similar as marker substances for determination of the GFR.

Evaluation of single sample clearance calculations in 902 patients

1997 ◽  
Vol 38 (1) ◽  
pp. 68-72 ◽  
Author(s):  
S. Lundqvist ◽  
S. O. Hietala ◽  
S. Groth ◽  
J. G. Sjödin
Keyword(s):  
Plasma Sample ◽  
Fluorescence Analysis ◽  
Single Sample ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
X Ray ◽  
Multiple Sample ◽  
Single Plasma ◽  
Selection Of

Purpose: To derive new formulae for the calculation of single sample clearance of the contrast medium iohexol and to compare the formulae to a selection of existing single sample clearance formulae derived for the calculation of 51Cr-EDTA and 99mTc-DTPA clearance. Material and Methods: Glomerular filtration rate (GFR) was calculated from total plasma clearance of iohexol used for urography in 902 patients. Two plasma samples were drawn in each patient. Automated x-ray fluorescence analysis equipment was used for the plasma iodine analysis. Single and multiple sample iohexol clearance values were compared. In 77 patients the multiple sample clearance values were additionally compared to a 51Cr-EDTA clearance performed simultaneously or within 14 days. Results: The precision of the results calculated by the existing single sample clearance formulae and the derived iohexol single sample clearance formulae were essentially the same. The most precise of the derived formulae was that based on the Bak Christensen & Groth formula. The correlation between multiple sample clearance of iohexol and 51Cr-EDTA was high (r=0.918) Conclusion: Iohexol can substitute 51Cr-EDTA for GFR measurement. A valid GFR can be calculated from a single plasma sample determination of iohexol clearance using either the existing formulae or the new formulae derived from the present study.

Estimating Kidney Function during Urography

1987 ◽  
Vol 28 (5) ◽  
pp. 587-592 ◽  
Author(s):  
S. Sjoberg ◽  
S. Hellsten ◽  
T. Almen ◽  
K. Golman ◽  
T. Grönberg
Keyword(s):  
Contrast Medium ◽  
Kidney Function ◽  
Single Injection ◽  
Plasma Concentrations ◽  
Fluorescence Analysis ◽  
Blood Samples ◽  
Simultaneous Injection ◽  
X Ray ◽  
Gamma Counting

Blood samples were taken from 21 subjects at 2 to 4 hours after simultaneous injection of contrast medium (metrizoate) for urography and 51Cr-EDTA. Clearance calculations were performed using the single injection (single slope) technique. The plasma concentrations of 51Cr-EDTA and contrast medium were measured by gamma counting and X-ray fluorescence analysis, respectively. A good correlation was found between the clearance of 51Cr-EDTA and clearance of contrast medium (r=0.94).

Total plasma clearance of 51Cr-EDTA: Variation with age and sex in normal adults

2000 ◽  
Vol 21 (2) ◽  
pp. 187-192 ◽  
Author(s):  
D HAMILTON ◽  
P RILEY ◽  
U MIOLA ◽  
D MOUSA ◽  
W POPOVICH ◽  
...  
Keyword(s):  
Plasma Clearance ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
51Cr Edta ◽  
Normal Adults ◽  
Age And Sex
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