Levels of uric acid may predict the future development of pulmonary hypertension in systemic lupus erythematosus: a seven-year follow-up study

Lupus ◽  
2015 ◽  
Vol 25 (1) ◽  
pp. 61-66 ◽  
Author(s):  
D Castillo-Martínez ◽  
E Marroquín-Fabián ◽  
A C Lozada-Navarro ◽  
M Mora-Ramírez ◽  
M Juárez ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pulmonary Hypertension ◽  
Uric Acid ◽  
Future Development ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Follow Up Study ◽  
The Future

Five-year follow-up study of the prevalence and progression of pulmonary hypertension in systemic lupus erythematosus

1995 ◽  
Vol 129 (3) ◽  
pp. 510-515 ◽  
Author(s):  
Timothy M. Winslow ◽  
Maxim A. Ossipov ◽  
Gary P. Fazio ◽  
Jay S. Simonson ◽  
Rita F. Redberg ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pulmonary Hypertension ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Follow Up Study

scholarly journals Serum uric acid is associated with damage in patients with systemic lupus erythematosus

2020 ◽  
Vol 7 (1) ◽  
pp. e000366 ◽  
Author(s):  
Claudia Elera-Fitzcarrald ◽  
Cristina Reátegui-Sokolova ◽  
Rocio Violeta Gamboa-Cardenas ◽  
Mariela Medina ◽  
Francisco Zevallos ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Lupus Erythematosus ◽  
Cox Regression ◽  
Activity Index ◽  
Damage Index ◽  
Systemic Lupus ◽  
The Impact

IntroductionSerum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.ObjectiveTo determine whether serum uric acid levels are associated with new damage in patients with SLE.MethodsThis is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.ResultsWe evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).ConclusionHigher serum uric acid levels are associated with global damage in patients with SLE.

scholarly journals High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension

2014 ◽  
Vol 18 (5) ◽  
pp. 524-532 ◽  
Author(s):  
Ki-Jo Kim ◽  
In-Woon Baek ◽  
Yune-Jung Park ◽  
Chong-Hyeon Yoon ◽  
Wan-Uk Kim ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pulmonary Hypertension ◽  
Uric Acid ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Flares in Chinese systemic lupus erythematosus patients: a 6-year follow-up study

2017 ◽  
Vol 36 (12) ◽  
pp. 2727-2732 ◽  
Author(s):  
Liying Peng ◽  
Ziqian Wang ◽  
Mengtao Li ◽  
Yanhong Wang ◽  
Dong Xu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Follow Up Study

scholarly journals AB0486 Incidence of vertebral fractures: 8 years follow-up study in women with systemic lupus erythematosus

2017 ◽  
Author(s):  
C Mendoza Pinto ◽  
MDLL Leon Vazquez ◽  
A Montiel Jarquin ◽  
H Sandoval-Cruz ◽  
MA Buendía Luca ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vertebral Fractures ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Follow Up Study

scholarly journals Dysfunction of CD27+IgD+B Cells Correlates With Aggravated Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
wei zhang ◽  
YF Wang ◽  
Fanlei Hu ◽  
Fuai Lu ◽  
Tao Wu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cells ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Statistical Significance ◽  
Systemic Lupus ◽  
Follow Up Study ◽  
Healthy Control ◽  
Natural Igm

Abstract Objective：The apoptotic signaling pathway is obviously disordered in systemic lupus erythematosus (SLE). Natural IgM (nIgM) is important in clearing apoptotic cells and preventing them from triggering deleterious autoimmunity. B-1- and innate-like B- (ILBs) cells are the main nIgM producers. Human CD27+IgD+B cells (un-switched memory B cells) are considered ILBs. However, their functional properties in SLE remain undefined.Methods：Peripheral blood samples of 50 SLE patients and 50 healthy control were collected, and twelve SLE patients were assessed in a follow-up study. The amounts of CD27+IgD+ B cell was analyzed by flow cytometry. The IgM and IL-10 levels of CD27+IgD+ B cell were assessed by ELISPOT and qRT-PCR. SPSS 17.0 (SPSS, USA) was employed for data analysis. P<0.05 indicated statistical significance.Result：92.0% were females, 17-67 years. CD27+IgD+B cell amounts are significantly decreased in SLE patients than healthy control (p<0.01). CD27+IgD+B cell amounts were positively correlated with WBC(r=0.337, p=0.017), platelet count(r=0.396, p=0.004) and serum C3 levels(r=0.415, p=0.003), CD27+IgD+B cell amounts showed negative correlations with serum creatinine levels(r=-0.285, p=0.045), SLEDAI(r=-0.724, p=0.000), anti-dsDNA(r=-0.477, p=0.000) and CRP(r=-0.398,p=0.004). The IgM and IL-10 levels of CD27+IgD+B in SLE were decreased than healthy control (p<0.001), moreover CD27+IgD+B cells are increased in SLE cases after treatment in SLE patients than before treatment(p<0.001).Conclusion：CD27+IgD+B cell amounts are significantly decreased and it was correlated with clinical and immunological features in SLE patients. CD27+IgD+B cells had impaired function regarding IgM and IL-10 production in SLE, however, CD27+IgD+B cells amounts are recovered in SLE cases with treatment-related disease remission.

Anti-Ena Antibodies in Systemic Lupus Erythematosus: a Follow-Up Study

1985 ◽  
pp. 309-312
Author(s):  
A. d'ASCANIO ◽  
G. TARTARELLI ◽  
R. NERI ◽  
O. DI MUNNO ◽  
F. MARIANI ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Follow Up Study
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