Transformation of a non-secretory neuroendocrine tumor to insulinoma after treatment with Sunitinib: A case report and review of the literature

2018 ◽  
Vol 25 (6) ◽  
pp. 1516-1519 ◽  
Author(s):  
Todd Clover ◽  
Amrou Abdelkader ◽  
Guru Subramanian Guru Murthy
Keyword(s):  
Case Report ◽  
Blood Glucose ◽  
Neuroendocrine Tumor ◽  
Case Series ◽  
Epigenetic Changes ◽  
Review Of The Literature ◽  
Lower Blood Glucose ◽  
Lower Blood ◽  
Cancer Phenotype ◽  
Neuroendocrine Cancers

We report a case of a non-secretory neuroendocrine tumor which transformed into an insulin secreting tumor after treatment with Sunitinib. To our knowledge, this has only been described in three other cases worldwide. Previously reported case series find transformation of non-secretory neuroendocrine cancers into secretory lesions occurs in 3.4–6.8% of cases. Sunitinib is known to have the potential to lower blood glucose and induce epigenetic changes in cells of various types. We hypothesize that the mechanism for Sunitinib-induced transformation in cancer phenotype is through epigenetic changes in DNA expression within the tumor cells.

scholarly journals Rational Use of Protein Supplements in the Elderly—Relevance of Gastrointestinal Mechanisms

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1227
Author(s):  
Ian Chapman ◽  
Avneet Oberoi ◽  
Caroline Giezenaar ◽  
Stijn Soenen
Keyword(s):  
Blood Glucose ◽  
Older People ◽  
The Elderly ◽  
Time Intervals ◽  
Lower Blood Glucose ◽  
Protein Supplements ◽  
Protein Requirements ◽  
Lower Blood ◽  
Older Subjects

Protein supplements are increasingly used by older people to maintain nutrition and prevent or treat loss of muscle function. Daily protein requirements in older people are in the range of 1.2 gm/kg/day or higher. Many older adults do not consume this much protein and are likely to benefit from higher consumption. Protein supplements are probably best taken twice daily, if possible soon after exercise, in doses that achieve protein intakes of 30 gm or more per episode. It is probably not important to give these supplements between meals, as we have shown no suppressive effects of 30 gm whey drinks, and little if any suppression of 70 gm given to older subjects at varying time intervals from meals. Many gastrointestinal mechanisms controlling food intake change with age, but their contributions to changes in responses to protein are not yet well understood. There may be benefits in giving the supplement with rather than between meals, to achieve protein intakes above the effective anabolic threshold with lower supplement doses, and have favourable effects on food-induced blood glucose increases in older people with, or at risk of developing, type 2 diabetes mellitus; combined protein and glucose drinks lower blood glucose compared with glucose alone in older people.

scholarly journals Cutaneous Metastasis of Neuroendocrine Carcinoma with Unknown Primary Site: Case Report and Review of the Literature

2015 ◽  
Vol 7 (3) ◽  
pp. 263-274 ◽  
Author(s):  
Gustavo Moreira Amorim ◽  
Danielle Quintella ◽  
Tullia Cuzzi ◽  
Rosangela Rodrigues ◽  
Marcia Ramos-e-Silva
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Carcinoma ◽  
Medical Literature ◽  
Cutaneous Metastasis ◽  
Primary Site ◽  
Skin Metastasis ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Review Of The Literature

We report a new case of neuroendocrine carcinoma for which it was not possible to find the primary site until now. The recent medical literature about skin metastasis of neuroendocrine carcinoma (neuroendocrine tumor) is discussed.

scholarly journals Neuroendocrine tumor in the liver of a patient with isolated polycystic liver disease: A case report and review of the literature

2013 ◽  
Vol 5 (5) ◽  
pp. 1664-1666 ◽  
Author(s):  
KONSTANTINOS KOUTSAMPASOPOULOS ◽  
ELISAVET ANTONIADOU ◽  
STAVROS ZOUTIS ◽  
GRIGORIOS IACOVIDIS ◽  
OLGA BUROVA ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Disease ◽  
Neuroendocrine Tumor ◽  
Polycystic Liver Disease ◽  
Review Of The Literature ◽  
Polycystic Liver

scholarly journals Neuroendocrine tumor of the common bile duct: a case report and review of the literature

2018 ◽  
Vol Volume 11 ◽  
pp. 2295-2301 ◽  
Author(s):  
Zhong Liu ◽  
Deng-Yong Zhang ◽  
Zheng Lu ◽  
Pei Zhang ◽  
Wan-Liang Sun ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Neuroendocrine Tumor ◽  
Review Of The Literature ◽  
The Common

scholarly journals Hepatic pseudocystic metastasis of well-differentiated ileal neuroendocrine tumor: a case report with review of the literature

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Stefano Fiori ◽  
Alessandro Del Gobbo ◽  
Gabriella Gaudioso ◽  
Lucio Caccamo ◽  
Sara Massironi ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Review Of The Literature ◽  
Well Differentiated

Investigating the relationship between lentil carbohydrate fractions and in vivo postprandial blood glucose response by use of the natural variation in starch fractions among 20 lentil varieties

2017 ◽  
Vol 8 (10) ◽  
pp. 3783-3791 ◽  
Author(s):  
D. Dan Ramdath ◽  
Qiang Liu ◽  
Elizabeth Donner ◽  
Aileen Hawke ◽  
Danusha Kalinga ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Natural Variation ◽  
Starch Content ◽  
Postprandial Blood Glucose ◽  
Glucose Response ◽  
Lower Blood Glucose ◽  
Blood Glucose Response ◽  
Lower Blood ◽  
The Relationship

Using human studies we confirm that lentils lower blood glucose response, which is correlated to the rapidly digestible starch and resistant starch content.

scholarly journals Including Garlic in the Diet May Help Lower Blood Glucose, Cholesterol, and Triglycerides

2006 ◽  
Vol 136 (3) ◽  
pp. 800S-802S ◽  
Author(s):  
Martha Thomson ◽  
Khaled K. Al-Qattan ◽  
Tanuja Bordia ◽  
Muslim Ali
Keyword(s):  
Blood Glucose ◽  
Lower Blood Glucose ◽  
Lower Blood

scholarly journals Noodles Made from High Amylose Wheat Flour Attenuate Postprandial Glycaemia in Healthy Adults

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2171
Author(s):  
Kim Ang ◽  
Carla Bourgy ◽  
Haelee Fenton ◽  
Ahmed Regina ◽  
Marcus Newberry ◽  
...  
Keyword(s):  
Young Adults ◽  
Blood Glucose ◽  
Wheat Flour ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Lower Blood Glucose ◽  
Postprandial Glycaemia ◽  
Lower Blood ◽  
High Amylose ◽  
Blood Glucose Concentrations

Previous research has not considered the effect of high amylose wheat noodles on postprandial glycaemia. The aim of the study is to investigate the effect of consumption of high amylose noodles on postprandial glycaemia over 2-h periods by monitoring changes in blood glucose concentration and calculating the total area under the blood glucose concentration curve. Twelve healthy young adults were recruited to a repeated measure randomised, single-blinded crossover trial to compare the effect of consuming noodles (180 g) containing 15%, 20% and 45% amylose on postprandial glycaemia. Fasting blood glucose concentrations were taken via finger-prick blood samples. Postprandial blood glucose concentrations were taken at 15, 30, 45, 60, 90 and 120 min. Subjects consuming high amylose noodles made with flour containing 45% amylose had significantly lower blood glucose concentration at 15, 30 and 45 min (5.5 ± 0.11, 6.1 ± 0.11 and 5.6 ± 0.11 mmol/L; p = 0.01) compared to subjects consuming low amylose noodles with 15% amylose (5.8 ± 0.12, 6.6 ± 0.12 and 5.9 ± 0.12 mmol/L). The total area under the blood glucose concentration curve after consumption of high amylose noodles with 45% amylose was 640.4 ± 9.49 mmol/L/min, 3.4% lower than consumption of low amylose noodles with 15% amylose (662.9 ± 9.49 mmol/L/min), p = 0.021. Noodles made from high amylose wheat flour attenuate postprandial glycaemia in healthy young adults, as characterised by the significantly lower blood glucose concentration and a 3.4% reduction in glycaemic response.

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