Prevention and Treatment of Doxorubicin-Induced Cardiotoxicity by Dexrazoxane and Schisandrin B in Rabbits

2011 ◽  
Vol 30 (6) ◽  
pp. 681-689 ◽  
Author(s):  
Feifei Che ◽  
Yu Liu ◽  
Caigang Xu
Keyword(s):  
Low Income ◽  
Troponin I ◽  
Low Cost ◽  
Serum Levels ◽  
Low Income Countries ◽  
Schisandrin B ◽  
Protective Effects ◽  
Alternative Drug ◽  
Echocardiographic Parameters ◽  
The Cost

The cost of dexrazoxane, a drug used to provide protection from doxorubicin-induced cardiotoxicity, limits its use in low-income countries. We aimed to see whether schisandrin B, an inexpensive drug, could provide protection equivalent to that provided by dexrazoxane. New Zealand white rabbits were randomly divided into groups and treated with saline, doxorubicin, doxorubicin + dexrazoxane, or doxorubicin + schisandrin B. Doxorubicin-induced damage and the protective effects were studied by recording the echocardiographic parameters and serum levels of superoxide dismutase, malondialdehyde, cardiac troponin I, and brain natriuretic peptide and observing the histology and degree of apoptosis. Schisandrin B had dose-dependent effects in decreasing the magnitude of doxorubicin-induced indicators of cardiomyopathy to a degree that approximated the decrease produced by dexrazoxane treatment. Schisandrin B might be a useful, low-cost alternative drug for this application.

scholarly journals Evaluation of a Low-Cost Commercial Actigraph and Its Potential Use in Detecting Cultural Variations in Physical Activity and Sleep

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3774
Author(s):  
Pavlos Topalidis ◽  
Cristina Florea ◽  
Esther-Sevil Eigl ◽  
Anton Kurapov ◽  
Carlos Alberto Beltran Leon ◽  
...  
Keyword(s):  
Physical Activity ◽  
Low Income ◽  
Large Scale ◽  
Low Cost ◽  
Low Income Countries ◽  
Time Data ◽  
Cultural Variations ◽  
Step Counts ◽  
Scale Step ◽  
Potential Use

The purpose of the present study was to evaluate the performance of a low-cost commercial smartwatch, the Xiaomi Mi Band (MB), in extracting physical activity and sleep-related measures and show its potential use in addressing questions that require large-scale real-time data and/or intercultural data including low-income countries. We evaluated physical activity and sleep-related measures and discussed the potential application of such devices for large-scale step and sleep data acquisition. To that end, we conducted two separate studies. In Study 1, we evaluated the performance of MB by comparing it to the GT3X (ActiGraph, wGT3X-BT), a scientific actigraph used in research, as well as subjective sleep reports. In Study 2, we distributed the MB across four countries (Austria, Germany, Cuba, and Ukraine) and investigated physical activity and sleep among these countries. The results of Study 1 indicated that MB step counts correlated highly with the scientific GT3X device, but did display biases. In addition, the MB-derived wake-up and total-sleep-times showed high agreement with subjective reports, but partly deviated from GT3X predictions. Study 2 revealed similar MB step counts across countries, but significant later wake-up and bedtimes for Ukraine than the other countries. We hope that our studies will stimulate future large-scale sensor-based physical activity and sleep research studies, including various cultures.

scholarly journals Adaptation and validation for Colombia of the WHO safe childbirth checklist

2018 ◽  
Vol 49 (3) ◽  
pp. 201-212
Author(s):  
Ana Carolina Amaya Arias ◽  
Óscar Zuluaga ◽  
Douglas Idárraga ◽  
Javier Hernando Eslava Schmalbach
Keyword(s):  
Low Income ◽  
Health Workers ◽  
Low Cost ◽  
Neonatal Morbidity ◽  
Neonatal Care ◽  
World Health ◽  
Low Income Countries ◽  
Safe Childbirth Checklist ◽  
Health Organization ◽  
Safe Childbirth

Introduction: Most maternal deaths that occur in developing countries are considered unfair and can be avoided. In 2008, The World Health Organization (WHO) proposed a checklist for childbirth care, in order to assess whether a simple, low-cost intervention had an impact on maternal and neonatal mortality in low-income countries. Objective: To translate, adapt and validate the content of the WHO Safe Childbirth Checklist (SCC) for its use in Colombia Methods: The checklist was translated and adapted to the Colombian context. It was subsequently validated by a panel of experts composed of 17 health workers with experience in maternal and neonatal care and safety. Reliability among judges was estimated (Rwg) and items were modified or added to each section of the list according to the results. Results: Modifications were made to 28 items, while 19 new items were added, and none was removed. The most important modifications were made to the management guidelines included in each item, and the items added refer to risks inherent to our environment. Conclusion: The Colombian version of the SCC will be a useful tool to improve maternal and neonatal care and thereby contribute to reducing maternal and neonatal morbidity and mortality in our country.

scholarly journals Fe0/H2O Filtration Systems for Decentralized Safe Drinking Water: Where to from Here?

Water ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 429 ◽  
Author(s):  
Charles Nanseu-Njiki ◽  
Willis Gwenzi ◽  
Martin Pengou ◽  
Mohammad Rahman ◽  
Chicgoua Noubactep
Keyword(s):  
Drinking Water ◽  
Low Income ◽  
Universal Access ◽  
Low Cost ◽  
Low Income Countries ◽  
Future Research ◽  
Systematic Research ◽  
Safe Drinking Water ◽  
Iron Corrosion ◽  
Small Communities

Inadequate access to safe drinking water is one of the most pervasive problems currently afflicting the developing world. Scientists and engineers are called to present affordable but efficient solutions, particularly applicable to small communities. Filtration systems based on metallic iron (Fe0) are discussed in the literature as one such viable solution, whether as a stand-alone system or as a complement to slow sand filters (SSFs). Fe0 filters can also be improved by incorporating biochar to form Fe0-biochar filtration systems with potentially higher contaminant removal efficiencies than those based on Fe0 or biochar alone. These three low-cost and chemical-free systems (Fe0, biochar, SSFs) have the potential to provide universal access to safe drinking water. However, a well-structured systematic research is needed to design robust and efficient water treatment systems based on these affordable filter materials. This communication highlights the technology being developed to use Fe0-based systems for decentralized safe drinking water provision. Future research directions for the design of the next generation Fe0-based systems are highlighted. It is shown that Fe0 enhances the efficiency of SSFs, while biochar has the potential to alleviate the loss of porosity and uncertainties arising from the non-linear kinetics of iron corrosion. Fe0-based systems are an affordable and applicable technology for small communities in low-income countries, which could contribute to attaining self-reliance in clean water supply and universal public health.

scholarly journals An IoT Smart Broiler Farming Model for Low Income Farmers

2018 ◽  
Vol 6 (3) ◽  
pp. 95
Author(s):  
Hazael Phiri ◽  
Douglas Kunda ◽  
Jackson Phiri
Keyword(s):  
Low Income ◽  
Cost Model ◽  
Low Cost ◽  
Ease Of Use ◽  
Climate Control ◽  
Proposed Model ◽  
Zigbee Protocol ◽  
Gsm Network ◽  
The Cost ◽  
Broiler House

<p class="Abstract"><span lang="EN-US">The coming of Internet of things (IoT) brings opportunities for the deploying of wireless sensor networks. One area of deployment is smart poultry farming to improve the quality and security of chicken varieties that include broilers. The quality of broilers produced is dependent on the environment in which the broilers are kept. In addition, the revenue of the farmer is guaranteed if theft of stock is prevented. The current methods farmers use are labour intensive and time consuming as they are manual. Leveraging the features of IoT and sensors can help to monitor the environment and ensure adverse conditions are reported for farmers to take action before they harm the livestock. Incorporating intruder detection when monitoring conditions in the environment can also prevent stock theft and that can increase the income obtained by farmers. For such a system to be widely adopted by low income farmers, the cost should be low compared commercially available climate control systems that are meant for commercial farmers. The system should also provide ease of use for less technically skilled farmers, reduce the time taken by farmers to take action in controlling theft and conditions in the environment and be accessible from any location other than the broiler house. In this paper, we propose a low-cost model that can be used to monitor conditions in the environment of a broiler house and send the values to the farmer in real-time. The proposed model is based on open source microcontrollers, ZigBee protocol, GSM network, mobile applications and cloud computing. </span></p>

Development of improved low-cost ceramic water filters for viral removal in the Haitian context

2014 ◽  
Vol 5 (1) ◽  
pp. 28-38 ◽  
Author(s):  
L. Guerrero-Latorre ◽  
M. Rusiñol ◽  
A. Hundesa ◽  
M. Garcia-Valles ◽  
S. Martinez ◽  
...  
Keyword(s):  
Low Income ◽  
Low Cost ◽  
World Health ◽  
Low Income Countries ◽  
Virus Removal ◽  
Ceramic Water Filters ◽  
Removal Efficiencies ◽  
Reductive Atmosphere ◽  
Health Organization ◽  
Water Filters

Household-based water treatment (HWT) is increasingly being promoted to improve water quality and, therefore, health status in low-income countries. Ceramic water filters (CWFs) are used in many regions as sustainable HWT and have been proven to meet World Health Organization (WHO) microbiological performance targets for bacterial removal (2–4 log); however, the described viral removal efficiencies are insufficient to significantly reduce the associated risk of viral infection. With the objective of improving the viral removal efficiencies of ceramic water filters, new prototypes with different oxide compositions and firing atmospheres have been developed and evaluated. For removal efficiencies human adenoviruses, MS2 bacteriophage and Escherichia coli were quantified in all prototypes. A new model of CWF that was fired in a reductive atmosphere presented virus and bacteria removal efficiencies greater than 3.0 log and 2.5 log, respectively, which would fulfill the viral targets that are recommended by the WHO. Ceramic characterization of the selected filters, which were fired in a reductive atmosphere, showed that a larger specific surface area than those of control filters and higher fraction of a positive Z-potential fraction are the most likely explanations for this increase in virus removal.

scholarly journals Therapies Out of Reach: Anticancer Drugs and Global Trade Regimes

2018 ◽  
Vol 23 (3) ◽  
pp. 371-387
Author(s):  
Dwaipayan Banerjee ◽  
James Sargent
Keyword(s):  
Anticancer Drugs ◽  
Low Income ◽  
Low Income Countries ◽  
High Price ◽  
Global Trade ◽  
Trade Regimes ◽  
History Of ◽  
Policy Analysts ◽  
The Cost ◽  
New Generation

Medical policy analysts and oncologists have cautioned against the high price of anticancer drugs. They argue that the current drug development model that relies on patents and short-term shareholder value is proving unsustainable, since the cost of the new generation of drugs puts many of them out of reach for the average consumer. The high price of cancer drugs is especially troubling in the context of middle- and low-income countries, where the burden of cancer carries disproportionate impact. To analyse the pricing of anticancer drugs, we examined legal controversies, regulatory treaties and documents, as well as the history of pricing data in India. We also conducted interviews with policy consultants and surveyed financial data filings of major global and Indian pharmaceutical corporations. Our research revealed that global trade agreements have become key barriers to lowering anticancer drug prices. This article argues that in the shadow of the World Trade Organization (WTO) and with Trans-Pacific Partnership (TPP) imminent, serious policy changes are necessary to ensure the survival of generic production in the market for anticancer drugs.

scholarly journals The reversible adjustable coupling: A lightweight and low-cost alignment component for the lower limb prosthesis

2017 ◽  
Vol 4 ◽  
pp. 205566831770642
Author(s):  
Kazuhiko Sasaki ◽  
Jutamat Pinitlertsakun ◽  
Pakwan Nualnim ◽  
Gary Guerra ◽  
Yuttapichai Sansook ◽  
...  
Keyword(s):  
Low Income ◽  
Lower Limb ◽  
External Rotation ◽  
Low Cost ◽  
Low Income Countries ◽  
Strength Tests ◽  
Lower Limb Prosthesis ◽  
Repetitive Loading ◽  
Limb Prosthesis ◽  
Anterior Posterior

Background The alignment of the lower limb prosthesis is an integral part of the prosthetic fitting. A properly aligned prosthesis contributes to optimal gait and overall function of the patient. The current offering of alignment componentry is expensive for low-income countries. The purpose of this study was to develop a lightweight and low-cost alignment coupler for the lower limb prosthesis. Methods An alignment coupler called the reversible adjustable coupling was designed and manufactured. Measurements of total anterior/posterior and medial/lateral and rotation in prostheses were recorded and mechanical testing performed. Swiftness and difficulty of use was also recorded. Results The reversible adjustable coupling permitted acceptable ranges of anterior/posterior and medial/lateral translation and 30° of internal and external rotation of prosthetic componentry. Repetitive loading of the coupling at a speed of 1 Hz under 1.28 kN load for 2000 cycles was successful, as were static and strength tests. Discussion The coupler provided acceptable ranges of anterior/posterior and medial/lateral and rotation adjustment and is acceptable for potential use in the alignment of both exoskeletal and endoskeletal prosthesis. The final weight of the component was 166 g and cost of $55.00 USD is affordable for low-income countries for use in clinical and educational settings.

scholarly journals Is physiotherapy an underused approach to prevent surgery in selective musculoskeletal disorders?

2021 ◽  
Vol 20 (2) ◽  
pp. 409-413
Author(s):  
Junaid Amin ◽  
Sameer Gohir ◽  
Umer Qaiser ◽  
Ammar A Siddiqui ◽  
Freah Alshammary ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Musculoskeletal Disorders ◽  
Low Income ◽  
Medical Science ◽  
Low Income Countries ◽  
Long Term Outcomes ◽  
Physiotherapy Intervention ◽  
Musculoskeletal Problems ◽  
The Cost

Objectives: The purpose of the literature review was to appraise the evidence that an early physiotherapy intervention helps to prevent the surgery in selective musculoskeletal disorders. A search of Google Scholar, Web of Science, Scopus, and PubMed was carried out utilizing the terms (“physiotherapy”, “surgery” OR “exercise, surgery” OR “rehabilitation”, “surgery”). Methods: The article titles and abstracts were screened for eligibility and included in the review. The recent literature evidently emphasized that physiotherapy has opted in selective musculoskeletal problems to avoid and delay surgeries. Results: Regardless of recommended conservative treatment option and effectiveness of physiotherapy, a massive gap can be observed between its evidence and practice. Conversely, overuse of diagnostic imaging, surgeries, and medications is present in clinical practice. In most of the clinical problems the long-term outcomes were reported the same with surgical and physiotherapy intervention. Likewise, patients can also get the advantage of better clinical outcome and cost-effectiveness with physiotherapy as compared to surgical intervention. Conclusion: The cost-effectiveness is an important factor in low-income countries where economic aspects of health care are highly considered. These advantages of physiotherapy should be considered by the clinicians, policymakers, patients, and included in the clinical guidelines. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.409-413

scholarly journals Performance Evaluation of a low cost integrated collector storage solar water heater with independent plane reflectors

2015 ◽  
Vol 49 (3) ◽  
pp. 147-154
Author(s):  
Zakariya Kaneesamkandi
Keyword(s):  
Low Income ◽  
Storage Systems ◽  
Low Cost ◽  
Heating System ◽  
Low Income Countries ◽  
Water Heating ◽  
Water Heater ◽  
Beam Radiation ◽  
Solar Water Heating ◽  
Solar Water

High initial cost is one of the reasons why consumers think twice before investing on the conventional solar water heating systems, especially in low income countries. Integrated collector storage systems are available at a lesser cost, but with a penalty of decreased efficiency. In this paper, yet another attempt to reduce cost of solar water heating system has been made by using independent plane reflectors along with an insulated storage tank provided with a heat absorbing aperture. With no tracking arrangement, this system uses only the intense beam radiation available from 9:00 AM to 3:00 PM with a concentration factor of 10. A theoretical study was conducted using commercial computational fluid dynamics software which was followed by an experimental validation of the results. The theoretical results were in agreement with the experimental results. The efficiency of this system was less than collector storage systems reported in the literature by about 10-15%. Maximum average tank temperature of 350 K and efficiency of 0.61 was obtained. Overall loss coefficient was identical with that of existing integrated collector storage systems. DOI: http://dx.doi.org/10.3329/bjsir.v49i3.22128 Bangladesh J. Sci. Ind. Res. 49(3), 147-154, 2014

scholarly journals The development of a nano-sized eggshell and titanium dioxide desensitising paste to re-mineralise teeth

2019 ◽  
Author(s):  
◽  
Stanley Chibuzor Onwubu
Keyword(s):  
Calcium Carbonate ◽  
Low Income ◽  
Logistic Equation ◽  
Low Income Countries ◽  
Hydrated Silica ◽  
Dentin Tubule ◽  
The Cost ◽  
Bovine Enamel ◽  
New Evidence

in). Manuscript I established that as the brushing days increase the remineralisation or dentin tubule occluded by each respective desensitising agent improved. It was found that the occluding capabilities of EB@TiO2 were more superior to both Pro-argin and NovaMin products in both saliva and without saliva. Manuscript II described the use of the logistic equation to predict the remineralisation of the EB@TiO2. Manuscript II established that the logistic equation effectively predicted the remineralisation trends of EB@TiO2 and Pro-argin toothpaste (Colgate Pro-relief). Manuscript III assesses the abrasivity of EB@TiO2 in comparison with calcium carbonate, and hydrated silica containing toothpaste. Bovine enamel specimen was used for the in vitro experiment. Manuscript III established that enamel loss from the brushed surface, regardless of the sample group, were statistically different when compared to the covered surface. The study found that the abrasivity of EB@TiO2 were comparable with the calcium carbonate toothpaste. It was also established that EB@TiO2 was less abrasive when compared against hydrated silica containing toothpaste. In conclusion, the experimental finding has exhaustively provided evidence on the suitability of EB@TiO2 as an active ingredient in toothpaste formulation. The study, therefore, provides new evidence and approach for the management of DH, particularly in low-income countries where the cost of oral healthcare may be too high.

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