Evaluating the Role of Serotonin on Neuropsychological Function After Breast Cancer Using Acute Tryptophan Depletion

Although cognitive dysfunction is a prevalent and disruptive problem for many breast cancer survivors (BCSs), little research has examined its etiology. One potential mechanism that remains to be explored is serotonin. Serotonin has been implicated in normal and dysfunctional cognitive processes, and serotonin levels are significantly affected by estrogen withdrawal, a common side effect of breast cancer treatment. However, no study has evaluated serotonin’s role on cognitive dysfunction in BCSs. The purpose of this study was to examine the role of serotonin in cognitive dysfunction in survivors by lowering central serotonin concentrations via acute tryptophan depletion (ATD). Based on previous research in noncancer populations, we hypothesized that alterations in central serotonin levels would induce cognitive dysfunction in these women controlling for confounding characteristics such as fluctuating mood and glucose levels. Secondarily, we explored whether genetic variations in serotonin genes would partly explain ATD. Participants included 20 female BCSs, posttreatment for nonmetastatic breast cancer, who received ATD or control in a double-blind, crossover design. Cognitive performance was measured at the 5-hr tryptophan/serotonin nadir on each test day using standardized neuropsychological tests. Specific impairment was noted in episodic memory (delayed recall) and motor speed during ATD versus control. ATD did not alter new learning (immediate recall), working memory, verbal fluency, or information processing speed. Findings suggest that serotonin may play a critical role in memory consolidation and motor functioning in BCSs.

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Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

Menopause The Journal of The North American Menopause Society ◽

10.1097/gme.0b013e318199e9f6 ◽

2009 ◽

Vol 16 (4) ◽

pp. 644-652 ◽

Cited By ~ 9

Author(s):

Janet S. Carpenter ◽

Menggang Yu ◽

Jingwei Wu ◽

Diane Von Ah ◽

Jennifer Milata ◽

...

Keyword(s):

Breast Cancer ◽

Hot Flashes ◽

Acute Tryptophan Depletion ◽

Tryptophan Depletion

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Mammary gland adipocytes in lactation cycle, obesity and breast cancer

Reviews in Endocrine and Metabolic Disorders ◽

10.1007/s11154-021-09633-5 ◽

2021 ◽

Author(s):

Georgia Colleluori ◽

Jessica Perugini ◽

Giorgio Barbatelli ◽

Saverio Cinti

Keyword(s):

Breast Cancer ◽

Mammary Gland ◽

Epithelial Cells ◽

Close Association ◽

Critical Role ◽

Exocrine Gland ◽

Plastic Properties ◽

Lactation Cycle ◽

Gland Development

AbstractThe mammary gland (MG) is an exocrine gland present in female mammals responsible for the production and secretion of milk during the process of lactation. It is mainly composed by epithelial cells and adipocytes. Among the features that make the MG unique there are 1) its highly plastic properties displayed during pregnancy, lactation and involution (all steps belonging to the lactation cycle) and 2) its requirement to grow in close association with adipocytes which are absolutely necessary to ensure MG’s proper development at puberty and remodeling during the lactation cycle. Although MG adipocytes play such a critical role for the gland development, most of the studies have focused on its epithelial component only, leaving the role of the neighboring adipocytes largely unexplored. In this review we aim to describe evidences regarding MG’s adipocytes role and properties in physiologic conditions (gland development and lactation cycle), obesity and breast cancer, emphasizing the existing gaps in the literature which deserve further investigation.

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The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling

Nature Communications ◽

10.1038/s41467-021-24631-6 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Eui Jung Moon ◽

Stephano S. Mello ◽

Caiyun G. Li ◽

Jen-Tsan Chi ◽

Kaushik Thakkar ◽

...

Keyword(s):

Breast Cancer ◽

Tumor Invasion ◽

Critical Role ◽

Metastatic Breast ◽

Breast Cancer Patients ◽

Invasion And Metastasis ◽

Stat3 Signaling ◽

Inducible Genes ◽

Transcriptional Target

AbstractHypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In this study, we identify v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) as a potent regulator of tumor invasion without affecting cell viability. MAFF expression is elevated in metastatic breast cancer patients and is specifically correlated with hypoxic tumors. Combined ChIP- and RNA-sequencing identifies IL11 as a direct transcriptional target of the heterodimer between MAFF and BACH1, which leads to activation of STAT3 signaling. Inhibition of IL11 results in similar levels of metastatic suppression as inhibition of MAFF. This study demonstrates the oncogenic role of MAFF as an activator of the IL11/STAT3 pathways in breast cancer.

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Critical role of matrix metallopeptidase 9 in postoperative cognitive dysfunction and age-dependent cognitive decline

Oncotarget ◽

10.18632/oncotarget.15545 ◽

2017 ◽

Vol 8 (31) ◽

pp. 51817-51829 ◽

Cited By ~ 17

Author(s):

Jiangjiang Bi ◽

Weiran Shan ◽

Ailin Luo ◽

Zhiyi Zuo

Keyword(s):

Cognitive Decline ◽

Cognitive Dysfunction ◽

Critical Role ◽

Postoperative Cognitive Dysfunction ◽

Age Dependent ◽

Matrix Metallopeptidase ◽

Matrix Metallopeptidase 9

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The Critical Role of Axillary Ultrasound and Aspiration Biopsy in the Management of Breast Cancer Patients with Clinically Negative Axilla

Annals of Surgical Oncology ◽

10.1245/s10434-007-9524-3 ◽

2007 ◽

Vol 15 (1) ◽

pp. 250-255 ◽

Cited By ~ 29

Author(s):

J. L. Hinson ◽

P. McGrath ◽

A. Moore ◽

J. T. Davis ◽

Y. M. Brill ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Critical Role ◽

Aspiration Biopsy ◽

Breast Cancer Patients ◽

Axillary Ultrasound

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CXCR2: A Novel Mediator of Mammary Tumor Bone Metastasis

International Journal of Molecular Sciences ◽

10.3390/ijms20051237 ◽

2019 ◽

Vol 20 (5) ◽

pp. 1237 ◽

Cited By ~ 4

Author(s):

Bhawna Sharma ◽

Kalyan Nannuru ◽

Sugandha Saxena ◽

Michelle Varney ◽

Rakesh Singh

Keyword(s):

Breast Cancer ◽

Bone Metastasis ◽

Tumor Cell ◽

Cancer Patients ◽

Mammary Tumor ◽

Critical Role ◽

Breast Cancer Patients ◽

Mammary Tumor Cell ◽

Primary Tumors

Most breast cancer patients die due to bone metastasis. Although metastasis accounts for 5% of the breast cancer cases, it is responsible for most of the deaths. Sometimes even before the detection of a primary tumor, most of the patients have bone and lymph node metastasis. Moreover, at the time of death, breast cancer patients have the bulk of the tumor burden in their bones. Therapy options are available for the treatment of primary tumors, but there are minimal options for treating breast cancer patients who have bone metastasis. C-X-C motif chemokine receptor type 2 (CXCR2) receptor-mediated signaling has been shown to play a critical role during bone-related inflammations and its ligands C-X-C motif chemokine ligand 6 (CXCL6) and 8 (CXCL8) aid in the resorption of bone during bone metastasis. In this study, we tested the hypothesis that CXCR2 contributes to mammary tumor-induced osteolysis and bone metastasis. In the present study, we examined the role of both tumor cell-derived and host-derived CXCR2 in influencing mammary tumor cell bone metastasis. For understanding the role of tumor cell-derived CXCR2, we utilized Cl66 CXCR2 knockdown (Cl66-shCXCR2) and Cl66-Control cells (Cl66-Control) and observed a significant decrease in tumor growth and tumor-induced osteolysis in Cl66-shCXCR2 cells in comparison with the Cl66-Control cells. Next, for understanding the role of host-derived CXCR2, we utilized mice with genomic knockdown of CXCR2 (Cxcr2−/−) and injected Cl66-Luciferase (Cl66-Luc) or 4T1-Luciferase (4T1-Luc) cells. We observed decreased bone destruction and metastasis in the bone of Cxcr2−/− mice. Our data suggest the importance of both tumor cell- and host-derived CXCR2 signaling in the bone metastasis of breast cancer cells.

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Patients’ experiences of family members’ reactions to diagnosis of breast cancer and support in the management of breast cancer in Lagos, Nigeria

Palliative & Supportive Care ◽

10.1017/s147895152000070x ◽

2020 ◽

pp. 1-6

Author(s):

Samuel Ojima Adejoh ◽

Adetayo Olorunlana ◽

Adeola Adejayan

Keyword(s):

Breast Cancer ◽

Family Support ◽

Qualitative Method ◽

Private Hospital ◽

Critical Role ◽

Family Members ◽

Study Data ◽

Role Behavior ◽

Data Collection And Analysis

Abstract Objective The objectives of this study are to describe patients’ experiences of family members’ reactions to diagnosis of breast cancer and investigate the role of family support in the management of breast cancer. Method The study used the descriptive qualitative method in data collection and analysis. Fifteen participants, who were undergoing either radiotherapy or chemotherapy treatment at a private hospital, consented and participated in the study. Data were content analyzed under two specific themes on family members’ reactions and family support received. Findings The findings show that some participants reported negative reactions of some family members, and this affected them negatively. While some participants received support from their families, others did not. Significance of findings The findings of our study show the critical role of family support in the management of breast cancer; therefore, family members should be encouraged to give breast cancer patient the necessary support to help them manage their sick role behavior since their illness has no cure.

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