Bilateral Serous Macular Detachment as a Presenting Feature of Acute Lymphoblastic Leukemia

2005 ◽  
Vol 15 (2) ◽  
pp. 284-286 ◽  
Author(s):  
R. Malik ◽  
A. Shah ◽  
M.J. Greaney ◽  
A.D. Dick
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Systemic Chemotherapy ◽  
Bone Marrow Aspirate ◽  
Systemic Treatment ◽  
Lymphoblastic Leukemia ◽  
Serous Macular Detachment ◽  
Initial Sign ◽  
Visual Blurring

Purpose To report a case of bilateral serous maculopathy as an initial sign of acute lymphoblastic leukaemia in children. Methods/Results A 13-year-old girl, who presented with symptoms of visual blurring, was found to have a bilateral serous maculopathy. Haematological abnormalities (thrombocytopenia with a mild lymphocytosis) prompted further investigation. A bone marrow aspirate revealed the presence of leukemic blasts and a diagnosis of acute lymphoblastic leukaemia was made. Her maculopathy completely resolved following systemic chemotherapy. Conclusions Prompt recognition of disease led to early systemic treatment and restoration of visual function.

scholarly journals REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL

2021 ◽  
Vol 71 (2) ◽  
pp. 469-72
Author(s):  
Hafiz Muhammad Murtaza ◽  
Tariq Ghafoor ◽  
Muhammad Shaheen Iqbal
Keyword(s):  
Bone Marrow ◽  
United Kingdom ◽  
Acute Lymphoblastic Leukaemia ◽  
Induction Chemotherapy ◽  
Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukemia ◽  
Bone Marrow Aspiration ◽  
Military Hospital ◽  
Induction Treatment ◽  
Blast Cells

Objective: To find out the rate of remission of Pre-B Acute Lymphoblastic Leukaemia in children at the end of induction treatment with United Kingdom Acute Lymphoblastic Leukaemia (UKALL) 2011 chemotherapy protocol. Study Design: Prospective observational study. Place and Duration of Study: Paediatric Oncology Unit, Combined Military Hospital Rawalpindi, from Nov 2017 to Oct 2018. Methodology: Data of newly diagnosed patients of Pre-B Acute lymphoblastic Leukaemia, between 1 and 15 years of age was analysed. Patients were divided into low and high-risk groups and treated with United Kingdom Acute Lymphoblastic Leukaemia 2011 induction chemotherapy on regimens A and B respectively. Bone marrow aspiration was performed at the end of induction therapy (28 days), to document their remission status. Patients having ≤5% of blast cells were categorized to be in remission state and those with >5% blast cells were not considered in a state of remission. Results: A total of 79 patients, 45 (57%) male and 34 (43%) females were enrolled. The mean age was 5.79 ± 3.59 years. Fever (86.1%) and pallor (77.2%) were the most common presentations. Fifty-three (67.1%) patients were treated with regimen A and 26 (32.9%) had regimen B chemotherapy. Febrile neutropenia and myopathy were the most common complications seen in 73 (92.4%) and 54 (71.1%) patients respectively. Eight patients (10.1%) died during induction chemotherapy. Bone marrow aspiration done at the end showed a 100% rate of remission for both regimens A and B. Conclusion: Risk-based treatment of paediatric Acute lymphoblastic Leukaemia............

BONE-MARROW TRANSPLANTATION IN HIGH-RISK ACUTE LYMPHOBLASTIC LEUKAEMIA IN FIRST AND SECOND REMISSION

The Lancet ◽  
1987 ◽  
Vol 329 (8536) ◽  
pp. 786-789 ◽  
Author(s):  
RogerH. Herzig ◽  
A. John Barrett ◽  
Eliane Gluckman ◽  
StevenJ. Jacobsen ◽  
Tohru Masaoka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
High Risk ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Marrow Transplantation
Sign in / Sign up

Export Citation Format

Share Document