Tomographic characteristics of focal choroidal excavation and its association with retinal disorders

Purpose: To evaluate the morphological, clinical, and tomographic characteristics of focal choroidal excavation in the context of concomitant retinal pathologies. Methods: This case series included 13 eyes of 13 patients with focal choroidal excavation diagnosed by spectral-domain optical coherence tomography. Morphologic characteristics of excavation and quantitative thicknesses of retinal layers and choroid were analyzed in excavation area, area adjacent to excavation, and fellow eye without focal choroidal excavation by spectral-domain optical coherence tomography. Results: At the initial examinations, one eye had a history of blunt trauma, three eyes were diagnosed with choroidal neovascularization, one with choroidal osteoma, one with angioid streaks, one with retinal detachment, one with diabetic macular edema, one with optic pit, one with torpedo maculopathy, and the rest three with idiopathic focal choroidal excavation. The mean choroidal thickness in the area of focal choroidal excavation was statistically significantly thinner compared to in the area adjacent to focal choroidal excavation and fellow eye ( p < 0.001) and total average outer nuclear layer thickness was statistically significantly thicker in the area of excavation compared with fellow eye ( p = 0.007). Conclusion: This study confirmed the presence of focal choroidal excavation in various ocular diseases and the evaluation of focal choroidal excavation using the spectral-domain optical coherence tomography demonstrated choroidal thinning and outer nuclear layer thickening in the area of the excavation.

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Bilateral Multiple Focal Choroidal Excavations in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Case Reports in Ophthalmological Medicine ◽

10.1155/2019/7925737 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Ping Huang ◽

Tal Ben Ami ◽

Weiye Li

Keyword(s):

Optical Coherence Tomography ◽

Paroxysmal Nocturnal Hemoglobinuria ◽

Outer Nuclear Layer ◽

Spectral Domain ◽

Clinical Implications ◽

Optical Coherence ◽

Secondary Degeneration ◽

Focal Choroidal Excavation ◽

History Of ◽

Histopathological Evidence

Focal choroidal excavation (FCE) is an unusual configuration characterized by focal thinning and pitting of the choroid in the absence of staphyloma or scleral ectasia. The etiology and clinical implications of FCE are currently unknown. We report a case of bilateral multiple FCEs in a patient with a long history of paroxysmal nocturnal hemoglobinuria (PNH). Focal choriocapillaris thinning and hyperreflectivity of the adjacent outer nuclear layer were revealed by spectral domain optical coherence tomography, which suggests the occlusion of the choriocapillaries and secondary degeneration of the above photoreceptors. We hypothesize that thrombophilia in the condition of PNH played an important role in the formation of FCE. Although there is no histopathological evidence to support the association between the choroid changes and PNH, this case may offer new clues as for the etiology of FCE.

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Three Cases of Focal Choroidal Excavation in the Macula Detected by Spectral-Domain Optical Coherence Tomography

Journal of the Korean Ophthalmological Society ◽

10.3341/jkos.2014.55.6.941 ◽

2014 ◽

Vol 55 (6) ◽

pp. 941 ◽

Cited By ~ 1

Author(s):

Ju Hong Park ◽

Min Sagong ◽

Woo Hyok Chang

Keyword(s):

Optical Coherence Tomography ◽

Spectral Domain ◽

Optical Coherence ◽

Focal Choroidal Excavation

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Spectral Domain Optical Coherence Tomography Findings in a Case Series of Patients with Bilateral Diffuse Uveal Melanocytic Proliferation

Ocular Immunology and Inflammation ◽

10.3109/09273948.2014.926935 ◽

2014 ◽

Vol 22 (6) ◽

pp. 490-493 ◽

Cited By ~ 6

Author(s):

Zaid Shalchi ◽

Manoharan Shunmugam ◽

Omar A. Mahroo ◽

Robert J. McDonald ◽

Mahmut Dogramaci ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Case Series ◽

Spectral Domain ◽

Optical Coherence

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Two Cases of Focal Choroidal Excavation Detected by Spectral-Domain Optical Coherence Tomography

Case Reports in Ophthalmology ◽

10.1159/000337880 ◽

2012 ◽

Vol 3 (1) ◽

pp. 96-103 ◽

Cited By ~ 20

Author(s):

Takashi Katome ◽

Yoshinori Mitamura ◽

Fumika Hotta ◽

Masanori Niki ◽

Takeshi Naito

Keyword(s):

Optical Coherence Tomography ◽

Spectral Domain ◽

Optical Coherence ◽

Focal Choroidal Excavation

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An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series

BMC Ophthalmology ◽

10.1186/1471-2415-14-66 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 10

Author(s):

Yanling Ouyang ◽

Qing Shao ◽

Dirk Scharf ◽

Antonia M Joussen ◽

Florian M Heussen

Keyword(s):

Optical Coherence Tomography ◽

Case Series ◽

Spectral Domain ◽

Optical Coherence ◽

Easy Method

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Correlation between Argus II array–retina distance and electrical thresholds of stimulation is improved by measuring the entire array

European Journal of Ophthalmology ◽

10.1177/1120672119885799 ◽

2019 ◽

pp. 112067211988579 ◽

Cited By ~ 2

Author(s):

Lucy T Xu ◽

Aleksandra V Rachitskaya ◽

Meghan J DeBenedictis ◽

James Bena ◽

Shannon Morrison ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Measurement Method ◽

Case Series ◽

Spectral Domain ◽

Optical Coherence ◽

Four Corners ◽

Argus Ii ◽

Programming Software ◽

Entire Array ◽

Electrode Stimulation

Purpose: To describe two methods of measuring Argus II array–retina distance and to correlate array–retina distance to electrode stimulation thresholds. Methods: This was a case series of eight patients implanted with the Argus II. Spectral domain-optical coherence tomography array–retina distance was measured by two methods and correlated to corresponding electrode thresholds: (1) array–retina distance at each array corner and the largest array–retina distance and (2) using manual optical coherence tomography segmentation, the average array–retina distance was determined for each group of four electrodes. Patients 1–5 and 6–8 were analyzed separately due to a different threshold programming software. Results: The Spearman’s rank coefficient between array–retina distance and thresholds was −0.006 ( p = 0.98) for patients 1–5, and 0.16 ( p = 0.59) for patients 6–8 with the first method. The Spearman’s rank coefficient was 0.25 ( p < 0.001) for patients 1–5 and 0.36 ( p < 0.001) for patients 6–8 with the second method. Conclusion: There is a positive correlation between array–retina distance and threshold measurements when measuring the entire array but not when using a faster measurement method of four corners and largest array–retina distance.

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