scholarly journals Competing risks joint models using R-INLA

2021 ◽  
Vol 21 (1-2) ◽  
pp. 56-71
Author(s):  
Janet van Niekerk ◽  
Haakon Bakka ◽  
Håvard Rue
Keyword(s):  
Competing Risks ◽  
Count Data ◽  
Joint Model ◽  
Point Of View ◽  
Spatial Structures ◽  
Joint Models ◽  
Hazard Functions ◽  
Longitudinal Count Data ◽  
Non Gaussian ◽  
Made In

The methodological advancements made in the field of joint models are numerous. None the less, the case of competing risks joint models has largely been neglected, especially from a practitioner's point of view. In the relevant works on competing risks joint models, the assumptions of a Gaussian linear longitudinal series and proportional cause-specific hazard functions, amongst others, have remained unchallenged. In this article, we provide a framework based on R-INLA to apply competing risks joint models in a unifying way such that non-Gaussian longitudinal data, spatial structures, times-dependent splines and various latent association structures, to mention a few, are all embraced in our approach. Our motivation stems from the SANAD trial which exhibits non-linear longitudinal trajectories and competing risks for failure of treatment. We also present a discrete competing risks joint model for longitudinal count data as well as a spatial competing risks joint model as specific examples.

scholarly journals Competing risks joint models using R-INLA

2020 ◽  
pp. 1471082X1991365
Author(s):  
Janet van Niekerk ◽  
Haakon Bakka ◽  
Håvard Rue
Keyword(s):  
Competing Risks ◽  
Count Data ◽  
Joint Model ◽  
Point Of View ◽  
Spatial Structures ◽  
Joint Models ◽  
Hazard Functions ◽  
Longitudinal Count Data ◽  
Non Gaussian ◽  
Made In

The methodological advancements made in the field of joint models are numerous. None the less, the case of competing risks joint models has largely been neglected, especially from a practitioner's point of view. In the relevant works on competing risks joint models, the assumptions of a Gaussian linear longitudinal series and proportional cause-specific hazard functions, amongst others, have remained unchallenged. In this article, we provide a framework based on R-INLA to apply competing risks joint models in a unifying way such that non-Gaussian longitudinal data, spatial structures, times-dependent splines and various latent association structures, to mention a few, are all embraced in our approach. Our motivation stems from the SANAD trial which exhibits non-linear longitudinal trajectories and competing risks for failure of treatment. We also present a discrete competing risks joint model for longitudinal count data as well as a spatial competing risks joint model as specific examples.

scholarly journals A new Bayesian joint model for longitudinal count data with many zeros, intermittent missingness, and dropout with applications to HIV prevention trials

2019 ◽  
Vol 38 (30) ◽  
pp. 5565-5586
Author(s):  
Jing Wu ◽  
Ming‐Hui Chen ◽  
Elizabeth D. Schifano ◽  
Joseph G. Ibrahim ◽  
Jeffrey D. Fisher
Keyword(s):  
Hiv Prevention ◽  
Count Data ◽  
Joint Model ◽  
Longitudinal Count Data ◽  
Prevention Trials ◽  
Bayesian Joint Model

Functional joint models for chronic kidney disease in kidney transplant recipients

2021 ◽  
pp. 096228022110092
Author(s):  
Jianghu (James) Dong ◽  
Jiguo Cao ◽  
Jagbir Gill ◽  
Clifford Miles ◽  
Troy Plumb
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Transplantation ◽  
Kidney Disease ◽  
Kidney Function ◽  
Competing Risks ◽  
Chronic Kidney Disease Stage ◽  
Joint Model ◽  
Disease Stage ◽  
Joint Models ◽  
Disease Study

This functional joint model paper is motivated by a chronic kidney disease study post kidney transplantation. The available kidney organ is a scarce resource because millions of end-stage renal patients are on the waiting list for kidney transplantation. The life of the transplanted kidney can be extended if the progression of the chronic kidney disease stage can be slowed, and so a major research question is how to extend the transplanted kidney life to maximize the usage of the scarce organ resource. The glomerular filtration rate is the best test to monitor the progression of the kidney function, and it is a continuous longitudinal outcome with repeated measures. The patient’s survival status is characterized by time-to-event outcomes including kidney transplant failure, death with kidney function, and death without kidney function. Few studies have been carried out to simultaneously investigate these multiple clinical outcomes in chronic kidney disease stage patients based on a joint model. Therefore, this paper proposes a new functional joint model from this clinical chronic kidney disease study. The proposed joint models include a longitudinal sub-model with a flexible basis function for subject-level trajectories and a competing-risks sub-model for multiple time-to event outcomes. The different association structures can be accomplished through a time-dependent function of shared random effects from the longitudinal process or the whole longitudinal history in the competing-risks sub-model. The proposed joint model that utilizes basis function and competing-risks sub-model is an extension of the standard linear joint models. The application results from the proposed joint model can supply some useful clinical references for chronic kidney disease study post kidney transplantation.

Analyzing discontinuities in longitudinal count data: A multilevel generalized linear mixed model.

2020 ◽  
Author(s):  
James L. Peugh ◽  
Sarah J. Beal ◽  
Meghan E. McGrady ◽  
Michael D. Toland ◽  
Constance Mara
Keyword(s):  
Count Data ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Generalized Linear Mixed Model ◽  
Longitudinal Count Data

BIO-ENERGY FROM PHOTOSYNTHETIC ALLOYS FOR USE IN BIOGUALS AND BIOPRODUCTS

2019 ◽  
pp. 613-618
Author(s):  
Petar Kazakov ◽  
Atanas Iliev ◽  
Emil Ivanov ◽  
Dobri Rusev
Keyword(s):  
Technical Progress ◽  
Point Of View ◽  
Energy Sustainability ◽  
International Activities ◽  
Made In

Significant technical progress has been made in recent years in the development of algae-based bioenergy, and much of industrial and academic R&D projects have diverged from the biofuels strategy. This report summarizes the conclusions of a recently concluded symposium analyzing the prospects for using micro- and macroalgae as a feedstock for biofuels and bioenergy. It discusses international activities for the development of bio-energy and non-energy algae bioproducts, advances in the use of macroalgae (both non-cultivated and cultivated algae). Applications for various biochemical and thermochemical uses, bio-refining capabilities for various products, as well as an in-depth review of the process from the point of view of economy and energy sustainability are also given.

Multi-criteria Decision-making Applications Based on Set Valued Generalized Neutrosophic Quadruple Sets for Law

2021 ◽  
pp. 41-60
Author(s):  
Necmiye Merve Sahin ◽  
◽  
◽  
Merve Sena Uz
Keyword(s):  
Decision Making ◽  
Similarity Measure ◽  
Point Of View ◽  
Multi Criteria Decision Making ◽  
Legal Decisions ◽  
The Law ◽  
Made In

In this article, an algorithm has been introduced that enables judges to see the decisions that should be made in a way that is closest to the conscience and the law, without transferring the cases to the higher authorities, without anyone objecting to their decisions. This algorithm has been introduced depending on the generalized set-valued neutrosophic quadruple numbers and the Euclidean similarity measure in sets, what the decision is made by considering all the situations, regardless of which case the defendants come before the judge, how similar these decisions are to the legal decisions that should be made. In this way, we can easily see the decisions given to the accused in all kinds of cases, and we can arrange the decisions according to the similarity value. The closer the similarity value is to 1, the more correct the judge's decision from a legal point of view.

Gorald Enell. "Stomach ulcers". Library of the Practical Physician, Vol. 30. Giz. 1929, 123 pages, price 1 p.

1929 ◽  
Vol 25 (5) ◽  
pp. 582-583
Author(s):  
R. Luria
Keyword(s):  
Peptic Ulcer ◽  
Central Europe ◽  
Practical Interest ◽  
Living Conditions ◽  
Point Of View ◽  
Made In ◽  
Stomach Ulcers

The author aims to highlight the "peptic ulcer" (Die Magengeschwrkrankheit), its pathology and therapy from the point of view of a therapist. As you know, in addition to very detailed chapters in large manuals, many separate monographs are devoted to this issue (I will name only Yarotsky, Enriquez et Durand, Ruhman, Balint, F. Ramond, Tagepa from recent works), but the enormous practical interest presented by the doctrine of peptic ulcer makes it useful to cover the issue again; especially interesting are the observations made in a country where living conditions are somewhat different than: in central Europe, in Sweden

GUIDANCE IN MATERNAL AND INFANT CARE TWO MONTHS BEFORE AND AFTER THE BIRTH OF THE FIRST-BORN

PEDIATRICS ◽  
1948 ◽  
Vol 2 (2) ◽  
pp. 200-206
Author(s):  
AUGUSTA STUART CLAY
Keyword(s):  
Normal Growth ◽  
Point Of View ◽  
High School Education ◽  
Pediatric Care ◽  
New Haven ◽  
Private Physician ◽  
Healthy Pregnancy ◽  
Before And After ◽  
Haven Hospital ◽  
Made In

THIS study was made in the belief that family living and growth can be healthier if parents understand how mother and baby develop and what they need. Eleven mothers were visited weekly for two months before and after the birth of their firstborn to discover what guidance they wanted, what was offered, and what additional guidance was needed. The writer secured their cooperation by agreeing to work with them as a consultant, to interpret their point of view to the doctor, to explain medical instructions when permitted, and to teach the normal growth processes of mother and baby. Ten mothers were registered in the prenatal clinics of the New Haven Hospital; the eleventh had a private physician. They had no recorded problems beyond the needs of healthy pregnancy and they wanted to participate. Eight husbands agreed to take part in the study. The other three were overseas, but their wives reported for them. Backgrounds varied; 20 of the 22 had had college or high school education; all were between 18 and 32. None dropped out, and after the four months all asked for continued guidance. Cases were too few and the study too brief for statistical evidence. But problems were uncovered which needed to be considered and which have largely been neglected in routine obstetric and pediatric care. These parents wanted to learn—not in classes, but in the privacy of home—how to care for mother and baby without disrupting their accustomed way of living. All wanted the care and interest of one doctor for mother and one for baby. However, six women and five men preferred to talk with a consultant who was not a doctor, but who was affiliated with their doctors. The doctors seemed too busy for "little things" and "family affairs," and they saw so many doctors that they all seemed strangers. Once they felt sure that the consultant's interest was in themselves rather than in teaching them, they set the pace and pattern in the conference. There was no questionnaire, no probing, no set procedure. If they had any immediate interests or problems: job, move, presents, trips, in-laws, illness—these were discussed before they talked of pregnancy and baby.

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