A 5-Year Follow-Up of The Benefits of an Exercise Training Program in Liver Recipients Transplanted Due to Familial Amyloidotic Polyneuropathy

2018 ◽  
Vol 28 (4) ◽  
pp. 330-337
Author(s):  
Maria Teresa Tomás ◽  
Xavier Melo ◽  
Élia Mateus ◽  
Mafalda Gonçalves ◽  
Eduardo Barroso ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Exercise Training ◽  
Muscle Mass ◽  
Normal Activity ◽  
Familial Amyloidotic Polyneuropathy ◽  
Walking Capacity ◽  
And Function

Background: Supervised (SE) and home-based exercise (HBE) training regimes are effective on reconditioning patients with familial amyloidotic polyneuropathy (FAP) after liver transplantation, but research of the long-term retention of the benefits attained in patients with FAP has not yet been conducted. Purpose: In this 5-year follow-up study, we aimed to determine whether the exercise training gains in body composition, physical activity, and function promoted by a 24-week SE or HBE training regimes are retained in patients with FAP who resume normal activity. Methodology: Sixteen liver-transplanted patients with FAP were reassessed for body composition (dual X-ray absorptiometry), physical activity (questionnaire), and function (handgrip strength and 6-minute walk test). Results: Total body fat increased with both exercise regimes during follow-up ( P < .05; η2 = 0.432-0.625) as well as femoral neck bone density ( P = .048; η2 = 0.119). However, gains in upper limbs muscle quality during follow-up ( P < .001; η2 = 0.597) were only found in the SE group ( P = .042; η2 = 0.245). Both exercise regimes showed retaining aptitudes in walking capacity ( P < .05; η2 = 0.329-0.460) and muscle mass ( P = .05; η2 = 0.245). Still, none could retain the physical activity levels. Conclusion: Long-term resumption of normal activity following a 24-week SE or HBE regime in patients with FAP resulted in loss of exercise induced increases in physical activity but counterweighted postoperative losses in bone mineral density and substantially retained the benefits in walking capacity, muscle mass, and quality, in particular, in the SE group.

scholarly journals Effects of a 2-Year Supervised Exercise Program Upon the Body Composition and Muscular Performance of HIV-Infected Patients

2015 ◽  
Vol 9 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Lorena da Silva Paes ◽  
Juliana Pereira Borges ◽  
Fernanda Monteiro dos Santos ◽  
Taciana Pinto de Oliveira ◽  
Jaciara Gomes Dupin ◽  
...  
Keyword(s):  
Body Composition ◽  
Exercise Training ◽  
Muscle Mass ◽  
Highly Active Antiretroviral Therapy ◽  
Exercise Program ◽  
The Body ◽  
Supervised Exercise ◽  
Supervised Exercise Program ◽  
Total Muscle

Background :There is a lack of research investigating long-term effects of exercise training upon the body composition and muscle function in HIV-infected patients (PHIV). The study investigated the influence of a 2-year supervised exercise program on body composition and strength of PHIV under highly active antiretroviral therapy (HAART).Methods :A training program including aerobic, strength and flexibility exercises was performed by 27 PHIV (17 men/ 10 women; age: 48.7±7.0 years; HAART: 150.7±65.3 months) during 1 year and 18 PHIV (10 men/ 8 women; age: 50.6±5.2 years; HAART: 176.6±53.1 months) during 2 years. Body composition and knee isokinetic strength were assessed at baseline and at the end of each year of intervention.Results :Body composition remained stable along the whole experimentvsbaseline (1-year- total muscle mass: Δ men=1.1%,P=0.21; Δ women=1.4%,P=0.06; trunk fat: Δ men=-0.1%,P=0.65; Δ women=-1.5%,P=0.45;2 years- total muscle mass: Δ men=2.7%,P=0.54; Δ women=-1.9%,P=0.71; trunk fat: Δ men=4.4%,P=0.96; Δ women=10.0%,P=0.30). After 1-year, peak torque increased in men (Δ extension=4.2%,P=0.01; Δ flexion=12.2%,P=0.04) and total work reduced in women (Δ extension=-15.4%,P=0.01, Δ flexion=-17.5%,P=0.05). All strength markers remained stablevsbaseline after 2 years of intervention (P>0.05). Only men showed significant reduction in the risk of disability due to sarcopenia (P=0.05) after 1 year of intervention, which remained stable after 2 years.Conclusion :Long-term exercise training preserved strength and muscle mass in PHIV under HAART. Exercise programs should be part of HIV therapy to prevent sarcopenia of this population along the years.Trial Registration :ACTRN12610000683033; UTN U1111-1116-4416.

Long-term effects of supervised exercise training on walking capacity and quality of life in patients with intermittent claudication

VASA ◽  
2008 ◽  
Vol 37 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Keo ◽  
Grob ◽  
Guggisberg ◽  
Widmer ◽  
Baumgartner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Exercise Training ◽  
Intermittent Claudication ◽  
Long Term Effects ◽  
Supervised Exercise ◽  
Exercise Training Program ◽  
Walking Capacity

Supervised exercise training has been shown to improve walking capacity in several studies of patients with intermittent claudication. However, data on long-term outcome are quite limited. The aim of this prospective study was to evaluate long-term effects of supervised exercise training on walking capacity and quality of life in patients with intermittent claudication. Patients and methods: Sixty-seven consecutive patients with intermittent claudication who completed a supervised 12-week exercise training program were asked for follow up evaluation 39 ± 20 months after program completion. Pain-free walking distance (PWD) and maximum walking distances (MWD) were assessed by treadmill test and several questionnaires. Results: Forty (60%) patients agreed to participate, 22 (33%) refused participation, and 5 (7%) died during follow-up. PWD and MWD significantly improved at completion of 12-weeks supervised exercise training as compared to baseline (PWD 114 ± 100 vs. 235 ± 248, p = 0.002; MWD 297 ± 273 vs. 474 ± 359, p = 0.001). Improvement of PWD and MWD could be maintained at follow up (197 ± 254, p = 0.014; 390 ± 324, p = 0.035, respectively) with non-smokers showing significantly better sustained PWD and MWD improvement as compared to baseline. Overall, walking capacity correlated with functional status of quality of life. Conclusions: Major findings of this investigation were that improvement in walking capacity is sustained after completion of supervised exercise training program with best results in patients who quitted or never smoked. Improved walking capacity is associated with increased functional status of quality of life.

scholarly journals Long-Term Effects of Activity Status in the Elderly on Cardiorespiratory Capacity, Blood Pressure, Blood Lipids, and Body Composition: A Five-Year Follow-Up Study

2003 ◽  
Vol 3 ◽  
pp. 751-767 ◽  
Author(s):  
Eli Carmeli ◽  
Pini Orbach ◽  
David T. Lowenthal ◽  
Joav Merrick ◽  
Raymond Coleman
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Body Composition ◽  
Oxygen Uptake ◽  
Maximal Oxygen Uptake ◽  
The Elderly ◽  
Long Term Effects ◽  
Highly Active

It is generally recognized that physical activity levels in the elderly do not remain constant over time, and typically there is a marked reduction in physical activities in the elderly. The long-term benefits of regular physical training programs in the elderly are still not fully understood. This is a study of 55 elderly healthy subjects (over 65 years old) and re-evaluated for the effects of different physical activity patterns (sedentary, moderately active, and highly active) on several physiological parameters (pre- and post-training) after a 5-year period (5.30 ± 1.14 years). Measurements included: body composition, blood lipid profiles, resting systolic and diastolic blood pressure, maximal oxygen uptake, and pulmonary function. Results indicated a larger decrease in maximal oxygen uptake (VO2max) in the group of elderly sedentary individuals (1.5 ± 0.5 l/min) compared to the moderately active (1.7 ± 0.6 l/min) and the highly active groups (1.9 ± 0.4 l/min). An active lifestyle was not sufficient to increase the physiological function of an individual.This study could not clearly demonstrate favorable differences for the physically active groups over the sedentary group with regard to several important physiological factors over the 5-year follow-up and it appears that the recommendation for, and the initiation of, adopting active lifestyles may not be sufficient on their own to significantly increase an individual's physiological functioning.

scholarly journals Effects of Combined Aerobic-Strength Training vs Fitness Education Program in COPD Patients

2017 ◽  
Vol 38 (13) ◽  
pp. 1001-1008 ◽  
Author(s):  
Nicoletta Rinaldo ◽  
Elisabetta Bacchi ◽  
Giuseppe Coratella ◽  
Francesca Vitali ◽  
Chiara Milanese ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Body Composition ◽  
Muscle Strength ◽  
Education Program ◽  
Copd Patients ◽  
Walking Capacity ◽  
Health Related

AbstractWe compared the effects of a new physical activity education program approach (EDU), based on a periodically supervised protocol of different exercise modalities vs traditionally supervised combined strength-endurance training (CT) on health-related factors in patients with stable chronic obstructive pulmonary disease (COPD). Twenty-eight COPD patients without comorbidities were randomly assigned to receive either EDU or CT. CT was continuously supervised to combine strength-endurance training; EDU was taught to progressively increase the rate of autonomous physical activity, through different training modalities such as Nordic walking, group classes and circuit training. Body composition, walking capacity, muscle strength, flexibility and balance, total daily energy expenditure and quality of life were evaluated at baseline, after 28 weeks training period (3d/week) and after a 14-week follow-up. No adverse events occurred during the interventions. After training, CT and EDU similarly improved walking capacity, body composition and quality of life. However, after 14 weeks of follow-up, such improvements were not maintained. Only in CT, muscle strength and flexibility improved after training but returned to baseline after follow-up. EDU, similar to CT, can effectively and safely improve health-related parameters in COPD patients. EDU could be an attractive alternative to traditional supervised training for improving quality of life in COPD patients.

scholarly journals Persistent Uncontrolled Asthma: Long-Term Impact on Physical Activity and Body Composition

2021 ◽  
Author(s):  
Mustafa Abdo ◽  
Benjamin Waschki ◽  
Anne-Marie Kirsten ◽  
Frederik Trinkmann ◽  
Heike Biller ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Independent Predictor ◽  
Symptom Control ◽  
Asthma Severity ◽  
The Body ◽  
Uncontrolled Asthma ◽  
Asthma Patients

Abstract Rational Asthma, obesity and physical activity (PA) are interrelated. However, longitudinal data with objective PA measures and direct assessment of body composition are still lacking.Objectiveto study the impact of asthma severity and symptom control on PA and body composition.MethodsIn a longitudinal cohort study, we assessed the body composition of 233 asthma patients and 84 healthy controls using bioelectrical impedance analysis. PA (i.e. average daily steps and time of at least moderate activity, steps/min) was measured by accelerometry for one week. Asthma control was assessed by ACT score, ACQ-5 score and history of severe exacerbations. After two years of follow up, we studied changes in physical activity and body composition in relation to asthma control.ResultsPatients with severe asthma had increased fat mass and decreased muscle mass compared to patients with mild-moderate asthma or healthy controls. Both fat mass and muscle mass correlated better with asthma control than the body mass index (BMI). In multivariate regressions adjusted for confounders including asthma severity and corticosteroid therapy, physical activity was an independent predictor of body composition (R2 ≥ 0.61, p < 0.001). Persistent uncontrolled asthma patients (n=64) had lower physical activity at both baseline (6614 steps/118 min) and follow up (6195/115). Despite having stable BMI, they also had significant muscle loss (-1.2%, -0.88 kg, p<0.01) and fat accumulation (+1%, +1.1 kg, p<0.01). By contrast, temporarily uncontrolled or controlled asthma patients had higher physical activity at baseline (8670/156) and follow up (9058/153) with almost unchanged body composition.ConclusionPersistent uncontrolled asthma is associated with sustained physical inactivity and adverse changes in body composition that might be overlooked by relying solely on BMI. Physical activity is an independent predictor of body composition and reliable long-term marker of symptom control.

scholarly journals Long-Term Moderate Exercise Combined with Metformin Treatment Induces an Hormetic Response That Prevents Strength and Muscle Mass Loss in Old Female Wistar Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
David Hernández-Álvarez ◽  
Beatriz Mena-Montes ◽  
Rafael Toledo-Pérez ◽  
Gibrán Pedraza-Vázquez ◽  
Stefanie Paola López-Cervantes ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Muscle Mass ◽  
Wistar Rats ◽  
Redox State ◽  
The Body ◽  
Moderate Exercise ◽  
Female Wistar Rats ◽  
Hormetic Response

Sarcopenia is a syndrome characterized by a progressive and generalized skeletal muscle mass and strength loss, as well as a poor physical performance, which as strongly been associated with aging. Sedentary lifestyle in the elderly contributes to this condition; however, physical activity improves health, reducing morbidity and mortality. Recent studies have shown that metformin (MTF) can also prevent muscle damage promoting muscular performance. To date, there is great controversy if MTF treatment combined with exercise training improves or nullifies the benefits provided by physical activity. This study is aimed at evaluating the effect of long-term moderate exercise combined with MTF treatment on body composition, strength, redox state, and survival rate during the life of female Wistar rats. In this study, rats performed moderate exercise during 20 of their 24 months of life and were treated with MTF for one year or for 6 months, i.e., from 12 to 24 months old and 18 to 24 months old. The body composition (percentage of fat, bone, and lean mass) was determined using a dual-energy X-ray absorption scanner (DXA), and grip strength was determined using a dynamometer. Likewise, medial and tibial nerve somatosensory evoked potentials were evaluated and the redox state was measured by HPLC, calculating the GSH/GSSG ratio in the gastrocnemius muscle. Our results suggest- that the MTF administration, both in the sedentary and the exercise groups, might activate a mechanism that is directly related to the induction of the hormetic response through the redox state modulation. MTF treatment does not eliminate the beneficial effects of exercise throughout life, and although MTF does not increase muscle mass, it increases longevity.

scholarly journals Long-term effects of a modified, low-protein infant formula on growth and body composition: Follow-up of a randomized, double-blind, equivalence trial

2021 ◽  
Author(s):  
Stefanie M.P. Kouwenhoven ◽  
Nadja Antl ◽  
Martijn J.J. Finken ◽  
Jos W.R. Twisk ◽  
Eline M. van der Beek ◽  
...  
Keyword(s):  
Body Composition ◽  
Infant Formula ◽  
Long Term Effects ◽  
Double Blind ◽  
Equivalence Trial ◽  
Low Protein
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