scholarly journals Recent insights into atherosclerotic plaque cell autophagy

2021 ◽  
pp. 153537022110388
Author(s):  
Dan Ni ◽  
Zhongcheng Mo ◽  
Guanghui Yi

Cardiovascular and cerebrovascular diseases, such as coronary heart disease and stroke, caused by atherosclerosis have become the “number one killer”, seriously endangering human health in developing and developed countries. Atherosclerosis mainly occurs in large and medium-sized arteries and involves intimal thickening, accumulation of foam cells, and formation of atheromatous plaques. Autophagy is a cellular catabolic process that has evolved to defend cells from the turnover of intracellular molecules. Autophagy is thought to play an important role in the development of plaques. This review focuses on studies on autophagy in cells involved in the formation of atherosclerotic plaques, such as monocytes, macrophages, endothelial cells, dendritic cells, and vascular smooth muscle cells, indicating that autophagy plays an important role in plaque development. We mainly discuss the roles of autophagy in these cells in maintaining the stability of atherosclerotic plaques, providing a reference for the next steps to unravel the mechanisms of atherogenesis.

Author(s):  
Serdar Öztürk ◽  
Ali Sözdemir ◽  
Özlem Ülger

As a result of many countries don’t provide the achievement as regards the satisfaction of the price stability between 1970 and 1990, the other targets and the stability programs aimed at these targets were put away and price stability as a point target was put forward in this process. In this context, inflation targeting approach has been formed as providing price stability and the fight against the inflation after 1990s. The first application of inflation targeting approach by the New Zealand in 1990 affected The Central Bank of Republic of Turkey (CBRT), because of positive impacts on many countries such as developing and developed countries. The results of Inflation targeting approach that has been applied by many countries following New Zealand's experience are positive. Thus, CBRT explained to take place inflation targeting of the point target in monetary policy at the beginning of 2002. Because Turkey don’t provide with the application set of the preconditions for this approach, CBRT decided to remove the elements that is restricting monetary policy and carried into practice "the implicit inflation targeting" until meeting this conditions. In the process of implicit inflation targeting approach, after the conditions related technical infrastructure was improved a new opinion, The CBRT announced to practice "the explicit inflation targeting" approach by the beginning of 2006.


2016 ◽  
Vol 2 (2) ◽  
pp. 93-102
Author(s):  
Rehana Kausar ◽  
Zeeshan Mahmood ◽  
Ulfat Abbas

We empirically investigate the impact of liquidity framework proposed under Basel III, namely Net Stable Funding Ratio on Net Interest Margin for 385 banks in SAARC countries (Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka) along with five developed countries i.e. Australia, Canada, China, Japan and United State over 2003-2013. The NSFR in Basel III liquidity necessity intended to limit funding risk emerging from maturity conflicts between assets and liabilities of overall countries. The results indicate that there is also a gap between developing and developed countries to managing the stability of their funding source as well as liquidity of its assets is a benefit to them and is also transformed into net interest margin by comparison of developing and developed countries. In addition, this study also proved the findings of previous researches in developed countries that are relevant to bank determinants and net interest margin in the world.


2019 ◽  
Vol 16 (1) ◽  
pp. 70-81
Author(s):  
Azrul Azlan Iskandar Mirza ◽  
Asmaddy Haris ◽  
Ainulashikin Marzuki ◽  
Ummi Salwa Ahmad Bustamam ◽  
Hamdi Hakiem Mudasir ◽  
...  

The soaring housing prices in Malaysia is not a recent issue. It is a global phenomenon especially in developing and developed countries, driven by factors including land price, location, construction materials cost, demand, and speculation. This issue demands immediate attention as it affects the younger generation, most of whom could not afford to buy their own house. The government has taken many initiatives and introduced regulations to ensure that housing prices are within the affordable range. This article aims to introduce a housing price control element from the Shariah perspective, as an alternative solution for all parties involved in this issue. It adopts content analysis methodology on policy from Shariah approved sources.


Author(s):  
Matteo Migheli

AbstractBoth in developing and developed countries, farmers often do not protect themselves adequately, especially when applying agrochemicals that are dangerous for their health. The issue is relevant because insufficient protection is between the causes leading to intoxication of farmers and workers who handle these products. The literature suggests that both lack of training and information and low income may explain why, especially in developing countries, protective equipment is under-used. Using data from the Mekong Delta, this study addresses the issue of whether income and household wealth may help explaining the use of incomplete protections against pesticides. The results suggest that income, more than wealth, is a reason why Vietnamese farmers operating in the Mekong Delta fail in using adequate protections. In particular, the data suggest that they may prefer to divert resources to increasing the production of their fields or to buying goods that may be used both as protection and as everyday garments. This behaviour leads to underinvestment in some important protective goods. Possible public interventions to mitigate the problem are suggested; in particular, the promotion of integrated pest management techniques could be useful.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Faride Sadat Jalali ◽  
Parisa Bikineh ◽  
Sajad Delavari

Abstract Background Direct out-of-pocket payments (OOP) are among the most important financing mechanisms in many health systems, especially in developing countries, adversely affecting equality and leading vulnerable groups to poverty. Therefore, this scoping review study was conducted to identify the strategies involving OOP reduction in health systems. Methods Articles published in English on strategies related to out-of-pocket payments were Searched and retrieved in the Web of Science, Scopus, PubMed, and Embase databases between January 2000 and November 2020, following PRISMA guidelines. As a result, 3710 papers were retrieved initially, and 40 were selected for full-text assessment. Results Out of 40 papers included, 22 (55%) and 18 (45%) of the study were conducted in developing and developed countries, respectively. The strategies were divided into four categories based on health system functions: health system stewardship, creating resources, health financing mechanisms, and delivering health services.As well, developing and developed countries applied different types of strategies to reduce OOP. Conclusion The present review identified some strategies that affect the OOP payments According to the health system functions framework. Considering the importance of stewardship, creating resources, the health financing mechanisms, and delivering health services in reducing OOP, this study could help policymakers make better decisions for reducing OOP expenditures.


2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Kamoldeen Abiodun Ajijolakewu ◽  
Abiodun Saheed Ayoola ◽  
Tariq Oluwakunmi Agbabiaka ◽  
Folashade Rahmat Zakariyah ◽  
Nike Risikat Ahmed ◽  
...  

Abstract Background More people—in both developing and developed countries—now use, and are favourably disposed to, traditional medicine. Musa paradisiaca (plantain) is used extensively in traditional medicine across continents. In this review, we investigated the scientific justification of this extensive usage. Main body Generally, several studies validate usage in infectious diseases, but limited antiviral and in vivo reports exist. The mechanistic elicitation of antimicrobial activity has similarly not been ascertained. Contrarily, data abound from rigorous studies on physiological conditions. Activity across categories is tied to the potent phytosterols duo of stigmasterol and β-sitosterol; and the triterpenes viz. cycloeucalenone, 24-methylene-cycloartanol, and 31-norcyclolaudenone; present in plantain. Toxicity studies, while finite, suggest general safety and tolerance. Conclusions Findings in the studies reviewed projects plantain as a veritable source for drug bioprospecting that will be of benefit to scientific research and pharmaceutical industries.


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