Endovascular Treatment of Cancer-Associated Venous Obstruction: Comparison of Efficacy Between Stent Alone and Stent Combined With Linear Radioactive Seeds Strand

2020 ◽  
Vol 54 (7) ◽  
pp. 565-572
Author(s):  
Bei Wu ◽  
Guowen Yin ◽  
Xu He ◽  
Guoping Chen ◽  
Boxiang Zhao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Survival Time ◽  
Karnofsky Performance Status ◽  
Performance Status ◽  
Symptom Relief ◽  
Venous Obstruction ◽  
Significant Difference ◽  
Group A ◽  
Group B

Objectives: To investigate the safety and efficacy of a stent combined with a linear strand of 125I seeds to treat malignant cancer–associated venous obstruction. Methods: We retrospectively analyzed the data of 57 patients with malignant cancer–associated venous obstruction. Nineteen patients underwent the placement of a stent combined with a linear strand of 125I seeds (group A), and 38 patients underwent the placement of a bare stent (group B). The following parameters were compared between the 2 groups of patients: symptom relief rate, duration of venous patency, survival time, quality of life, and adverse events. Results: A total of 34 stents and 527 seeds were implanted in group A, while a total of 57 stents were implanted in group B. The surgery success rate was 96.5%, and no serious complication related to the surgery was reported. Symptoms of venous obstruction improved significantly after surgery. The score of group A decreased from 14.74 ± 0.562 points before surgery to 2.79 ± 1.357 points after surgery( P < .001), and the score of group B decreased from 13.79 ± 1.398 points before surgery to 5.55 ± 3.674 points after surgery ( P < .001). The patency rate of group A was significantly higher than that of group B at 1 to 6 months after surgery (100%, 84.2%, 68.4%, 63.2%, 36.8%, 21.1% vs 68.4%, 23.7%, 18.4%, 7.9%, 5.3%, 2.6%, respectively; P < .05). Before treatment, there was no statistically significant difference in the Karnofsky Performance Status (KPS) score between the groups ( P = .791). After 1 to 6 months of treatment, the KPS score was significantly higher in group A than in group B ( P = .013). The median patency duration in groups A and B was 125 days (95% CI: 80.018-169.982) and 35 days (95% CI: 20.501-49.499), respectively ( P < .001). The median survival time of group A was 155 days (95% CI: 110.406-199.594), and that of group B was 98 days (95% CI: 55.712-140.288; P = .325). Multivariate analysis showed that the implantation of a stent combined with a linear strand of 125I seeds and the KPS score (≥80 points) were independent factors of long-term patency after stent placement. Conclusions: The placement of a stent combined with a linear strand of 125I seeds is a safe and effective treatment for venous obstruction caused by malignant tumors. This treatment provides prolonged patency compared with the placement of bare stent, and while it does not significantly improve the survival time of patients, it can improve their quality of life.

scholarly journals COMPARISON BETWEEN THERAPEUTIC ULTRASOUND AND SCAR MOBILIZATION OVER PERSISTENT POSTNATAL DYSPAREUNIA

2017 ◽  
Vol 10 (9) ◽  
pp. 48
Author(s):  
Mariyam Farzana Sf ◽  
Ponmathi P ◽  
Sivakumar Pvr
Keyword(s):  
Quality Of Life ◽  
Analogue Scale ◽  
Therapeutic Ultrasound ◽  
Ultrasound Therapy ◽  
Age Group ◽  
Functional Index ◽  
Significant Difference ◽  
Group A ◽  
Group B

  Objective: Dyspareunia is known as the painful sexual intercourse. This study was conducted to compare the effectiveness between therapeutic ultrasound and scar mobilization in persistent postnatal dyspareunia.Methods: This is an experimental study. 30 subjects with superficial dyspareunia, age group between 25 and 35 years are taken in this study and 15 subjects in Group A were treated with ultrasound therapy, 15 subjects in Group B were treated with scar mobilization. Female sexual functional index questionnaire (FSFI) and visual analogue scale (VAS) were used as the outcome measure.Results: Results showed a significant difference in FSFI and VAS measurements in both the groups, but clinically Group A showed better improvement in pain and quality of life than Group B.Conclusion: There is no significant difference between ultrasound therapy and scar mobilization over the pain and quality of life in patients with persistent postnatal dyspareunia.

Septoplasty Improves Life Quality Related to Allergy in Patients with Septal Deviation and Allergic Rhinitis

2011 ◽  
Vol 145 (6) ◽  
pp. 910-914 ◽  
Author(s):  
Young Hyo Kim ◽  
Beom Joon Kim ◽  
Kang Hyun Bang ◽  
Yoonseok Hwang ◽  
Tae Young Jang
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Clinical Course ◽  
Septal Deviation ◽  
Vas Score ◽  
Medication Score ◽  
Significant Difference ◽  
Group A ◽  
Group B

Objective. Evaluate the effect of septoplasty on the clinical course of allergic rhinitis by comparing (1) symptom change using the Visual Analogue Scale (VAS), (2) change of the medication score, and (3) improvement of the quality of life using a questionnaire. Study Design. Prospective pilot. Setting. Academic tertiary rhinological practice. Subjects and Methods. Sixty-two patients who had undergone septoplasty and turbinoplasty for septal deviation and allergic rhinitis were enrolled in group A. Twenty-six patients who had undergone only turbinoplasty for allergic rhinitis were enrolled in group B. The VAS score, the Average Rescue Medication Score (ARMS), and the Rhinasthma Questionnaire for the quality of life were all obtained from each patient. These parameters were compared before and after the surgery and between the groups. Results. Both groups showed significant improvement of the VAS score ( P < .001). When the change of VAS was compared between groups, there was a significant difference in group A only for nasal obstruction ( P = .047). Comparison of the ARMS between groups showed significant improvement in both groups after the surgery ( P < .01). However, there were no differences between the groups. The Rhinasthma score of group A was significantly lowered after the surgery (56.4 ± 13.2 to 34.1 ± 12.3, P < .001). The Rhinasthma score of group A was significantly lower than that of group B after the surgery ( P = .004). Conclusions. This is the first research about the potential effect of septoplasty on the clinical course of allergic rhinitis. Further studies are needed to elucidate the mechanisms underlying these effects.

scholarly journals Effects of calisthenics on exercise capacity, symptoms and quality of life in COPD

2020 ◽  
Vol 11 (4) ◽  
pp. 6296-6300
Author(s):  
Ganapathy Sankar U ◽  
Monisha R
Keyword(s):  
Quality Of Life ◽  
Exercise Capacity ◽  
Research Centre ◽  
Chronic Obstructive ◽  
College Hospital ◽  
Obstructive Pulmonary Disease ◽  
Significant Difference ◽  
Group A ◽  
Group B

Chronic Obstructive Pulmonary Disease (COPD) is the leading cause of death and disability in India. The study aims to evaluate the effects of CSC- COPD Sitting Calisthenics on exercise capacity, symptoms and quality of life. Twenty-five patients with COPD admitted in SRM Medical college hospital, and research centre (Department of respiratory medicine) were included in the study. After calculating the samples of 25 with excluding one drop outpatient, randomly assigned 12 patients in each group, group A (n = 12), group B (n = 12) and the patients in two groups received five sessions of intervention (CSC and CET) in the hospital stay. The results indicate that there is a significant improvement in exercise capacity in callisthenics group on day 5 (P &lt; 0.001). There was no significant difference found for modified Borg's scale on day 5 in callisthenics group. QOL showed a statistically significant difference in Group A, and the current study concludes that callisthenics is effective in improving exercise capacity and QOL in patients diagnosed with COPD.

scholarly journals A study to compare the effectiveness of core strengthening exercises for phase I and phase II of menstrual cycle in primary dysmenorrhea subjects

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 315-317
Author(s):  
S Zainab ◽  
P. Nithyashree ◽  
R Jumanah ◽  
M Kamalakannan ◽  
Suganthirababu Prathap ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Menstrual Cycle ◽  
Phase I ◽  
Phase Ii ◽  
Primary Dysmenorrhea ◽  
Significant Difference ◽  
Strengthening Exercises ◽  
Group A ◽  
Group B

Introduction and Aim:The common gynaecological problem among females found to be Dysmenorrhea, which is a cramping pain in the lower abdomen occurring at menstruation in the absence of any identifiable pelvic disease with a prevalence rate of 60%-90%. The consequences of primary dysmenorrhea affect quality of life (QOL) and limitations in daily activities as well as absenteeism. There is no open literature on which phase of the menstrual cycle is better to exercise in and is more effective. The aim of this study was to compare the effectiveness of core strengthening exercises for Phase I and Phase II of menstrual cycle in primary dysmenorrhea subjects and find out which phase is best to exercise in.   Materials and Methods: A total of 150 subjects were selected using convenient sampling technique based on inclusion and exclusion criteria and randomly allotted into 2 groups (group A and group B)containing 75 subjects each. Group A (Phase I follicular phase)and group B (Phase II luteal phase) performed core strengthening exercise protocol for a duration of 3 menstrual cycles (12 weeks). Working ability, location, intensity, days of pain, dysmenorrhea (WaLIDD) score as well as EQ 5-D 5-L (Euroql5 dimension 5 level quality of life questionnaire) values were obtained before and after the intervention.   Results: An unpaired t-test of the post-test mean values of phase I and II groups show that there is a significant difference between the two groups(p-value<0.0001)   Conclusion: From the results,it can be concluded that there is a significant difference in effectiveness of core strengthening exercises between phase I and phase II and thus exercising in Phase I is most effective.  

scholarly journals Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bin Huang ◽  
Zuan Yu ◽  
Risheng Liang
Keyword(s):  
Quality Of Life ◽  
Survival Rate ◽  
Concurrent Chemoradiotherapy ◽  
Patient Survival ◽  
Cox Regression Analysis ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Objective Glioblastoma multiforme (GBM) is the most common primary malignant central nervous system (CNS) tumor. The Stupp regimen is the standard treatment, although the optimal number of temozolomide (TMZ) treatment cycles remains controversial. We compared the effects of standard 6 cycles versus > 6 cycles of TMZ chemotherapy post-surgery with concurrent chemoradiotherapy on primary GBM patient survival. Patients and methods We performed a single center retrospective study of GBM patients that underwent total resection, concurrent chemoradiotherapy, and at least 6 cycles of adjuvant TMZ chemotherapy from June 2011 to August 2018. Patients were divided into 2 groups based on adjuvant TMZ treatment plan: Group A(n = 27): standard 6-cycle adjuvant TMZ therapy and Group B(n = 26): > 6 cycles of adjuvant TMZ therapy. Primary endpoints were progression-free survival (PFS) and overall survival (OS). Continuous variables were analyzed by ANOVA, and the Kaplan-Meier method was used to evaluate PFS and OS. Univariate and multivariate COX analyses determined correlation between survival rates and covariates. We used The Mini Mental State Examination (MMSE) and Karnofsky Performance Status (KPS) to assess patients’ neurocognitive function and quality of life. Results After follow-up, median PFS was 15 months in in Group A (95%CI 9.5–20.5) and 20.1 months in Group B (95%CI 15.9–24.4). Group A median OS was 19.4 months (95%CI 15.5–23.2), compared to 25.6 months in Group B (95%CI 20.4–30.8). The 2-year survival rate of Groups A and B was 36% was 66%, respectively (P = 0.02). and 5-year survival was 7% in both. Multivariate COX regression analysis showed association between patient PFS and long-period adjuvant chemotherapy, but not OS. There were no significant difference in disability or quality of life during treatment with Stupp protocol, but differences in MMSE and KPS were in favour of the Groups B after year 1 of the treatment (P < 0.05). Conclusions Long-term adjuvant TMZ chemotherapy was beneficial for PFS and 2-year survival rate in GBM patients, and improved their quality of life contemporarily. But OS was not significantly improved.

scholarly journals Efficacy of adding Luvos® Healing Earth supplementation to mebeverine in improving symptoms and quality of life of patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial

2018 ◽  
Vol 5 (10) ◽  
pp. 2776-2783
Author(s):  
Marjan Mokhtare ◽  
Mohammadreza Asadipanah ◽  
Mansour Bahardoust ◽  
Arezoo Chaharmahali ◽  
Masoomeh Khalighi Sikaroudi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Demographic Data ◽  
Gastrointestinal Disorder ◽  
Young Males ◽  
Significant Difference ◽  
Group A ◽  
Irritable Bowel ◽  
Group B

Introduction: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Treatment can improve symptoms and social functioning in the patients. This study was designed to assess the effect of adding Luvos supplementation to mebeverine on improving symptoms and quality of life (QOL) in patients with diarrhea-predominant irritable bowel syndrome. Methods: Eighty patients with diarrhea-predominant IB, ages 18-65, were diagnosed by the Rome IV criteria and randomly assigned to the study. Forty patients (group A) received mebeverine (135 mg) twice a day (bid) plus Luvos®Healing Earth (1 sachet, bid). The other 41 patients (group B) received mebeverine (135 mg) bid for 4 weeks. Basic demographic data, Bristol score, symptom severity score, and QOL questionnaire were recorded at the start and completion of treatment. The data were analyzed by SPSS version 22. Results: Seventy one of the patients (35 and 36 patients in groups A and B, respectively) completed the study. The majority of the patients were young males, unmarried and highly educated. Diarrhea and QOL were both significantly improved in group A when compared to group B (P=0.036 and P=0.028, respectively). We did not find a significant difference (improvement) in abdominal pain or overall symptom score between group A (mebeverine + Luvos) compared to group B (mebeverine alone) (P=0.096 and P=0.071, respectively). Mild and tolerable adverse effects were observed in 2.8% (2/71) of the patients. Conclusion: According to our results, Luvos supplementation is safe, effective and well-tolerated in diarrhea-predominant irritable bowel syndrome patients. Further study with a larger sample size is recommended to evaluate the efficacy of this natural clay-like medicine.

scholarly journals Aerobic training versus strength exercises on muscle strength and quality of life for children with acute lymphoblastic leukemia

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Doaa Mohamed ◽  
Faten Abd Alazim ◽  
Elham Salem ◽  
Nesreen Ali ◽  
Dina Elgalaly
Keyword(s):  
Quality Of Life ◽  
Acute Lymphoblastic Leukemia ◽  
Muscle Strength ◽  
Training Program ◽  
Aerobic Training ◽  
Lymphoblastic Leukemia ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Background The treatment for children and adolescents with acute lymphoblastic leukemia (ALL) can lead to multiple adverse effects, including poor physical capacity and muscle weakness. This study aimed to determine which is more effective, aerobic exercises or modified strength training program, on muscle strength and quality of life (QOL) for children with ALL. Results In terms of muscle strength, there was a significant difference (P < 0.05) in selected group of muscles elbow flexors, shoulder abductors, hip flexors, knee extensors, and ankle dorsiflexors at both sides in group B compared with group A, whereas there was no significant difference (P > 0.05) between groups on QOL. Conclusion The outcomes of the study showed that there was a significant difference in the selected group of muscles at both sides in group B compared with group A; thus, the modified strength training program is more effective for muscle strength of children with ALL than aerobic training, but there was no significant difference between them on QOL. Trial registration The clinical trial registered in clinicaltrials.gov with an identifier number NCT03147365

scholarly journals Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival

2021 ◽  
Author(s):  
Bin Huang ◽  
Zuan Yu ◽  
Risheng Liang
Keyword(s):  
Quality Of Life ◽  
Survival Rate ◽  
Concurrent Chemoradiotherapy ◽  
Patient Survival ◽  
Total Resection ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Objective Glioblastoma multiforme (GBM) is the most common primary malignant central nervous system (CNS) tumor. The Stupp regimen is the standard treatment, although the optimal number of temozolomide (TMZ) treatment cycles remains controversial. We compared the effects of standard 6 cycles versus > 6 cycles of TMZ chemotherapy post-surgery with concurrent chemoradiotherapy on primary GBM patient survival. Patients and Methods: We performed a single center retrospective study of GBM patients that underwent total resection, concurrent chemoradiotherapy, and at least 6 cycles of adjuvant TMZ chemotherapy from June 2011 to August 2018. Patients were divided into 2 groups based on adjuvant TMZ treatment plan: Group A(n = 27): standard 6-cycle adjuvant TMZ therapy and Group B(n = 26): >6 cycles of adjuvant TMZ therapy. Primary endpoints were progression-free survival (PFS) and overall survival (OS). Continuous variables were analyzed by ANOVA, and the Kaplan-Meier method was used to evaluate PFS and OS. Univariate and multivariate COX analyses determined correlation between survival rates and covariates. We used The Mini Mental State Examination (MMSE) and Karnofsky Performance Status (KPS) to assess patients' neurocognitive function and quality of life. Results After follow-up, median PFS was 15 months in in Group A (95%CI 9.5–20.5) and 20.1 months in Group B (95%CI 15.9–24.4). Group A median OS was 19.4 months (95%CI 15.5–23.2), compared to 25.6 months in Group B (95%CI 20.4–30.8). The 2-year survival rate of Groups A and B was 36% was 66%, respectively (P = 0.02). and 5-year survival was 7% in both. Multivariate COX regression analysis showed association between patient PFS and long-period adjuvant chemotherapy, but not OS. There were no significant difference in disability or quality of life during treatment with Stupp protocol, but differences in MMSE and KPS were in favour of the Groups B after year 1 of the treatment (P < 0.05). Conclusions Long-term adjuvant TMZ chemotherapy benefits PFS and 2-year survival rate,Long-term adjuvant TMZ chemotherapy benefits PFS and 2-year survival rate. This could improve quality of life in survivorship,but not highly prognosticate for OS. We do not suggest prolonging TMZ maintenance therapy beyond six cycles in patients with glioblastoma after total resection.

scholarly journals ASSESSMENT AND COMPARISON OF QUALITY OF LIFE AND SYMPTOM RELIEF IN PATIENT OF INOPERABLE NON-METASTATIC NON SMALL CELL LUNG CANCER UNDERGOING DIFFERENT PALLIATIVE RADIATION THERAPY.

2020 ◽  
pp. 62-64
Author(s):  
Shampa Maity ◽  
Apurba Bikash Pramanik ◽  
Partha Dasgupta ◽  
Pulakesh Sinha ◽  
Debarshi Jana
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Survival Time ◽  
Performance Status ◽  
Symptom Relief ◽  
Locally Advanced ◽  
Poor Performance Status ◽  
Life Questionnaire ◽  
Health Related

Lung cancer incidence in Indian men is 54000, with mortality at 49000 and in females at much less 17000 with mortality at 15,000. The aim of our study is Health related QoL changes: By using EORTC Quality of Life Questionnaire (QLQ)-C30 and QLQ-LC13. All histology proven patients of locally advanced NSCLC attending Department of Radiotherapy, R.G.Kar Medical College & Hospital during study period from January, 2017 to July 2018. Patient with poor performance status and inoperable NSCLC causing pulmonary symptoms, hypofractionated, involved field radiotherapy 8.5 Gy in two fractions offer acceptable palliation with minimal toxicity. A clear advantage of the very short hypofractionated regimen is that it enable patients with a short expected survival time to spend more of their remaining time away from their hospital. Palliative radiotherapy plays an important role of palliation of symptomatic intrathoracic disease and in preservation of health related quality of life (HRQOL) in patients who have limited expected survival time and/or intolerance to combined chemotherapy and radical radiotherapy regimen.

scholarly journals Assessment of the quality of life and performance status in patients with oral submucous fibrosis in central India

2018 ◽  
Vol 91 (2) ◽  
pp. 203-208
Author(s):  
Revant H. Chole ◽  
Ranjitkumar Patil
Keyword(s):  
Quality Of Life ◽  
Head And Neck ◽  
Performance Status ◽  
Oral Submucous Fibrosis ◽  
European Organization ◽  
Group A ◽  
Submucous Fibrosis ◽  
And Performance ◽  
Group B

Background and aims. Measuring quality of life in patients with oral submucous fibrosis is of utmost importance in assessing treatment outcomes. This study examined the impact of oral submucous fibrosis and its treatment on the quality of life and performance status of persons with oral submucous fibrosis.Methods. Quality of life was measured in patients with oral submucous fibrosis using the European Organization for Research and Treatment of Cancer Quality of Life head and neck 35 Questionnaire (EORTC QLQ-C35); performance status was measured by Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), at four points in time: baseline, one month, two months and three months after start of treatment.Results. At the end of third month Group A and Group B showed 78% and 85% increase in mouth opening respectively. While the burning sensation of oral mucosa was decreased by 72% and 88% in group A and group B respectively (Z>1.96, P<0.05), there were significant differences in patients' quality of life and functioning at three points in time (P < 0.05).Conclusion. The European Organization for Research and Treatment of Cancer Quality of Life head and neck 35 Questionnaire and Performance Status Scale for Head and Neck Cancer Patients can be used successfully in potentially malignant disorders like oral submucous fibrosis. The results in this study will surely be a good guide forother studies on oral submucous fibrosis.

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