scholarly journals The MSBase pregnancy, neonatal outcomes, and women’s health registry

2021 ◽  
Vol 14 ◽  
pp. 175628642110091
Author(s):  
Vilija G. Jokubaitis ◽  
Olga Skibina ◽  
Raed Alroughani ◽  
Ayse Altintas ◽  
Helmut Butzkueven ◽  
...  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Assisted Reproductive Technologies ◽  
Management Strategies ◽  
Reproductive Technologies ◽  
Evidence Base ◽  
Neonatal Outcomes ◽  
Health Registry ◽  
The Impact

Background: Family planning and pregnancy decisions are key considerations in the management of women with multiple sclerosis (MS), who are typically diagnosed between the ages of 20–40 years. Despite a strong evidence base that pregnancy is not harmful for women with MS, many knowledge gaps remain. These include: best management strategies through pregnancy in the era of highly effective disease-modifying therapies (DMT); foetal risks associated with DMT exposure in utero or in relation to breastfeeding; knowledge base around the use of assisted reproductive technologies; the long-term impact of pregnancy on disease outcomes, as well as the impact of long-term DMT use on women’s health and cancer risk. Methods: Here, we describe the new MSBase pregnancy, neonatal outcomes and women’s health registry. We provide the rationale for, and detailed description of, the variables collected within the registry, together with data acquisition details. Conclusion: The present paper will act as a reference document for future studies.

scholarly journals Alteration of Genomic Imprinting after Assisted Reproductive Technologies and Long-Term Health

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 728
Author(s):  
Eguzkine Ochoa
Keyword(s):  
Embryonic Development ◽  
Experimental Evidence ◽  
Genomic Imprinting ◽  
Animal Studies ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Early Embryonic Development ◽  
Global Methylation ◽  
The Impact

Assisted reproductive technologies (ART) are the treatment of choice for some infertile couples and even though these procedures are generally considered safe, children conceived by ART have shown higher reported risks of some perinatal and postnatal complications such as low birth weight, preterm birth, and childhood cancer. In addition, the frequency of some congenital imprinting disorders, like Beckwith–Wiedemann Syndrome and Silver–Russell Syndrome, is higher than expected in the general population after ART. Experimental evidence from animal studies suggests that ART can induce stress in the embryo and influence gene expression and DNA methylation. Human epigenome studies have generally revealed an enrichment of alterations in imprinted regions in children conceived by ART, but no global methylation alterations. ART procedures occur simultaneously with the establishment and maintenance of imprinting during embryonic development, so this may underlie the apparent sensitivity of imprinted regions to ART. The impact in adulthood of imprinting alterations that occurred during early embryonic development is still unclear, but some experimental evidence in mice showed higher risk to obesity and cardiovascular disease after the restriction of some imprinted genes in early embryonic development. This supports the hypothesis that imprinting alterations in early development might induce epigenetic programming of metabolism and affect long-term health. Given the growing use of ART, it is important to determine the impact of ART in genomic imprinting and long-term health.

The Impact of Preeclampsia on Women’s Health: Cardiovascular Long-term Implications

2020 ◽  
Vol 75 (11) ◽  
pp. 703-709
Author(s):  
Rossana Orabona ◽  
Edoardo Sciatti ◽  
Enrico Sartori ◽  
Enrico Vizzardi ◽  
Federico Prefumo
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
The Impact

International Diabetes Federation –Putting Women and Diabetes on the Global Agenda

2010 ◽  
Vol 6 (2) ◽  
pp. 10
Author(s):  
Ann Keeling ◽  
Katie Dain ◽  
◽  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
International Diabetes Federation ◽  
Evidence Base ◽  
Reproductive Age ◽  
Political Commitment ◽  
Access To Health Services ◽  
Health Seeking ◽  
Middle Income ◽  
The Impact

Eighty per cent of the 300 million people with diabetes live in low- and middle-income countries and women represent half of this worldwide diabetes community. Gender roles and power dynamics shape vulnerability to diabetes, affect women’s health-seeking behaviour, access to health services and influence the impact of diabetes on women’s health. This creates a set of concerns that are specific to women. In addition, as the prevalence of type 2 diabetes in women of reproductive age has increased, so has the prevalence of gestational diabetes mellitus (GDM), a form of diabetes with onset or that is first recognised during pregnancy. GDM is a major cause of maternal and infant morbidity and mortality and a major factor in the intergenerational transmission of diabetes. The International Diabetes Federation (IDF) is responding to this aspect of the global diabetes epidemic by launching a new programme on women and diabetes. This programme will build the evidence base, promote awareness and political commitment, support gender-responsive health systems and empower women to take a leading role in diabetes prevention.

International Diabetes Federation—Putting Women and Diabetes on the Global Agenda

2010 ◽  
Vol 06 (01) ◽  
pp. 10 ◽  
Author(s):  
Ann Keeling ◽  
Katie Dain ◽  
◽  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
International Diabetes Federation ◽  
Evidence Base ◽  
Reproductive Age ◽  
Political Commitment ◽  
Access To Health Services ◽  
Health Seeking ◽  
Middle Income ◽  
The Impact

Eighty percent of the 300 million people with diabetes live in low- and middle-income countries and women represent half of this worldwide diabetes community. Gender roles and power dynamics shape vulnerability to diabetes, affect women’s health-seeking behavior and access to health services, and influence the impact of diabetes on women’s health. This creates a set of concerns that are specific to women. In addition, as the prevalence of type 2 diabetes in women of reproductive age has increased, so has the prevalence of gestational diabetes mellitus (GDM), a form of diabetes with onset or that is first recognised during pregnancy. GDM is a major cause of maternal and infant morbidity and mortality and a major factor in the intergenerational transmission of diabetes. The International Diabetes Federation (IDF) is responding to this aspect of the global diabetes epidemic by launching a new program on women and diabetes. This programme will build the evidence base, promote awareness and political commitment, support gender-responsive health systems and empower women to take a leading role in diabetes prevention.

scholarly journals Assisted Reproductive Technologies and Health-Related Issues Among Women and Children: A Research Review

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Laura Corradi ◽  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Health Risks ◽  
Metabolic Diseases ◽  
Ethical Issues ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Research Review ◽  
Risk Disclosure ◽  
Surrogate Mothers

From their first use in the late 1970s until the mid-1990s, Assisted Reproductive Technologies (ART) gave rise to serious concerns by feminists internationally. Their questions ranged from asking about health risks to ethical and political problems inherent in these technologies. However, over the last 25 years, interest in women’s health which used to be central to feminist theory and politics, progressively decreased and with it concerns about ART. Today, while the medical literature about health risks in ART is increasing, the topic of women’s health in relation to reproductive technologies remains marginal in feminist discourse, social sciences, and the mainstream media. On the basis of recent medical studies, published in peer reviewed scientific journals, this article aims to begin filling this gap. The author discusses adverse effects of ART for three groups of people from a feminist perspective: egg providers; surrogate mothers; and children who are born through in vitro fertilization (IVF), heterologous embryo transfer (HET), and surrogacy. Among the numerous health problems are ovarian hyper-stimulation syndrome (OHSS), birth defects, tumours in children, chromosomal damage, and cardiac and metabolic diseases. Serious questions arise about the long-term health of women who undergo repeated hormonal stimulations, sell their egg cells, or “rent” their wombs as surrogate mothers—a process entailing the exploitation of economically vulnerable women. It also addresses some of the ethical issues arising, such as the importance of risk disclosure to potential IVF users, egg providers, surrogate mothers and intended parents; children’s right to access all details regarding their genetic origins and their birth mother; and relevant psychosocial problems related to the use of ART. This paper calls for renewed critiques of women’s experiences with reproductive technologies so that they can become, yet again, an important part of the feminist movement.

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