scholarly journals Ircinal E, a New Manzamine Derivative from the Indonesian Marine Sponge Acanthostrongylophora ingens

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Mousa AlTarabeen ◽  
Georgios Daletos ◽  
Weaam Ebrahim ◽  
Werner E. G. Müller ◽  
Rudolf Hartmann ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
High Resolution ◽  
Cell Line ◽  
Marine Sponge ◽  
High Resolution Mass Spectrometry ◽  
Two Dimensional ◽  
Meoh Extract ◽  
L5178y Cell ◽  
Resolution Mass

Chemical investigation of the MeOH extract of the sponge Acanthostrongylophora ingens afforded the new manzamine derivative ircinal E (1), in addition to six known metabolites (2–7). The structure of the new compound was unequivocally elucidated using one- and two-dimensional NMR spectroscopy, as well as high-resolution mass spectrometry. Compounds 1–6 exhibited strong to moderate cytotoxicity against the murine lymphoma L5178Y cell line with IC50 values ranging from 2.8 to 21.7 μM.

scholarly journals Two New Tropane Alkaloids from the Bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae)

2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Emerson F. Queiroz ◽  
Boris Zanolari ◽  
Andrew Marston ◽  
David Guilet ◽  
Leila Burgener ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
High Resolution ◽  
Traditional Medicine ◽  
High Resolution Mass Spectrometry ◽  
Tropane Alkaloids ◽  
Tropane Alkaloid ◽  
High Resolution Mass ◽  
Indigenous Plant ◽  
Resolution Mass

Two new tropane alkaloid N-oxides substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae), a Brazilian indigenous plant, locally known as catuaba and used in traditional medicine as an aphrodisiac. The alkaloid structures were determined by a combination of high resolution mass spectrometry and multi-dimensional NMR spectroscopy.

scholarly journals A comparison of one-dimensional and microscale two-dimensional liquid chromatographic approaches coupled to high resolution mass spectrometry for the analysis of complex samples

2015 ◽  
Vol 7 (18) ◽  
pp. 7697-7706 ◽  
Author(s):  
Juri Leonhardt ◽  
Thorsten Teutenberg ◽  
Jochen Tuerk ◽  
Michael P. Schlüsener ◽  
Thomas A. Ternes ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Two Dimensional ◽  
Complex Samples ◽  
One Dimensional ◽  
Open Questions ◽  
Liquid Chromatographic ◽  
Resolution Mass

The interest in two-dimensional liquid chromatography separations is growing every year together with the number of open questions on the benefits.

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