Acute cerebral microbleeds at the edge of lacunar strokes: cause or result

2021 ◽  
pp. 197140092110428
Author(s):  
Keisuke Koizumi ◽  
Hiromasa Sato ◽  
Masahiro Ebitani ◽  
Kikuko Kaneko ◽  
Kazuhiro Oguchi ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Cerebral Microbleeds ◽  
Lacunar Infarction ◽  
Cerebral Microbleed ◽  
Over Time ◽  
Arterial Branch

We investigated the pathogenic relationship between cerebral microbleeds and lacunar strokes. Two cases of lacunar strokes in the region of the basal ganglia, a 72-year-old man and a 67-year-old man, were studied; both cases showed cerebral microbleeds in the stroke areas. The cerebral microbleeds were surrounded by oedema, and the oedema faded out over time, suggesting the cerebral microbleeds had developed acutely. The cerebral microbleeds were located at the ventrolateral edge of the lacunar infarctions, and the locations appeared to be at or near the sites of occlusion of the lenticulostriatal branches. Although a cerebral microbleed and a lacunar infarction may be two unrelated events on juxtapositioned vessels, or a cerebral microbleed may be haemorrhagic conversion of an infarction, a cerebral microbleed could cause an occlusion of the arterial branch, leading to lacunar infarction of its supplying territories.

scholarly journals ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly

2016 ◽  
Vol 12 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Stephanie A Ward ◽  
Parnesh Raniga ◽  
Nicholas J Ferris ◽  
Robyn L Woods ◽  
Elsdon Storey ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Primary Prevention ◽  
Magnetic Resonance ◽  
Controlled Trial ◽  
Brain Magnetic Resonance Imaging ◽  
Cerebral Microbleeds ◽  
Resonance Imaging ◽  
Healthy Elderly ◽  
Cerebral Microbleed

Rationale Cerebral microbleeds seen on brain magnetic resonance imaging are markers of small vessel disease, linked to cognitive dysfunction and increased ischemic and hemorrhagic stroke risk. Observational studies suggest that aspirin use may induce cerebral microbleeds, and associated overt intracranial hemorrhage, but this has not been definitively resolved. Aims ASPREE-NEURO will determine the effect of aspirin on cerebral microbleed development over three years in healthy adults aged 70 years and over, participating in the larger ‘ASPirin in Reducing Events in the Elderly (ASPREE)’ primary prevention study of aspirin. Sample size Five hundred and fifty-nine participants provide 75% power (two-sided p value of 0.05) to determine an average difference of 0.5 cerebral microbleed per person after three years. Methods and design A multi-center, randomized placebo-controlled trial of 100 mg daily aspirin in participants who have brain magnetic resonance imaging at study entry, one and three years after randomization and who undergo cognitive testing at the same time points. Study outcomes The primary outcome is the number of new cerebral microbleeds on magnetic resonance imaging after three years. Secondary outcomes are the number of new cerebral microbleeds after one year, change in volume of white matter hyperintensity, cognitive function, and stroke. Discussion ASPREE-NEURO will resolve whether aspirin affects the presence and number of cerebral microbleeds, their relationship with cognitive performance, and indicate whether consideration of cerebral microbleeds alters the risk-benefit profile of aspirin in primary prevention for older people. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12613001313729.

Abstract 17428: Impact of Asymptomatic Cerebral Microbleeds or Lacunar Infarction on Clinical Outcome in Patients With Coronary Artery Disease (CAD) Requiring Percutaneous Coronary Intervention

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Seiji Hokimoto ◽  
Noriaki Tabata ◽  
Tomonori Akasaka ◽  
Kenji Sakamoto ◽  
Kenichi Tsujita ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Percutaneous Coronary Intervention ◽  
Clinical Outcome ◽  
Coronary Intervention ◽  
Cardiovascular Death ◽  
Cerebral Microbleeds ◽  
Lacunar Infarction ◽  
Percutaneous Coronary ◽  
High Incidence ◽  
Artery Disease

Background: Patients with coronary artery disease (CAD) are often complicated with cerebrovascular disease (CVD). Although there are many reports on the relation between stoke with symptomatic signs and CAD, there are few studies on cerebral microbleeds or lacunar infarction without symptomatic signs. The aim was to examine the prevalence of cerebral microbleeds or lacunar infarction without symptoms and clinical outcome in CAD patients. Methods: Among 1,091 consecutive CAD patients who required percutaneous coronary intervention (PCI), patients with non-lacunar infarction more severe than lacunar infarction or old cerebral hemorrhage by computed tomography (CT) or magnetic resonance imaging (MRI) were excluded. We analyzed CAD patients with cerebral microbleeds or lacunar infarction without overt neurological signs (ML group; n=98, 71males) compared with patients without cerebral findings of CT or MRI and stroke history as control (N group; n=762, 525males). Clinical endpoints were cardiovascular death, myocardial infarction (MI), stroke, unstable angina and urgent revascularization. Results: ML group had a high age (72.9±9.6 vs. 69.2±10.8ys; P=0.001), high incidence of diabetes mellitus (58.2 vs. 47.2%; P=0.042), peripheral artery disease (21.4 vs. 11.5%; P=0.005), and renal dysfunction (49.0 vs. 37.3%; P=0.025), and high levels of fibrinogen (435 vs. 402mg/dl; P=0.005), and high brachial-ankle pulse wave velocity (1975 vs. 1786cm/sec; P=0.001) compared with N group. Cardiovascular event rate was significantly higher in ML group than in N group (11.2 vs. 4.7%, P=0.008). Details in clinical outcome were as follows: cardiovascular death (ML group vs. N group, 0 vs. 0.9%; P=0.341), MI (1.0 vs. 0.5%; P=0.544), stroke (4.1 vs.0.7%; P=0.002), unstable angina (5.1 vs. 2.5%; P=0.140), revascularization (2.0 vs. 0.7%; P=0.498), respectively. Multiple regression analysis identified findings of microbleeds or lacunar infarction as a predictor of clinical events (OR, 2.830; 95%CI, 1.328-6.031; P=0.007). Conclusions: There was high incidence of brain MRI or CT findings without symptom in CAD patients. We should pay attention to the asymptomatic patients with microbleeds or lacunar infarction irrespective of overt previous stroke.

scholarly journals The study on analysis of risk factors for severity of white matter lesions and its correlation with cerebral microbleeds in the elderly with lacunar infarction

Medicine ◽  
2020 ◽  
Vol 99 (4) ◽  
pp. e18865
Author(s):  
Yu-Ni Zhou ◽  
Hao-Yuan Gao ◽  
Fang-Fang Zhao ◽  
Ying-Chun Liang ◽  
Yuan Gao ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Lesions ◽  
The Elderly ◽  
Cerebral Microbleeds ◽  
Lacunar Infarction

Basal Ganglia Cerebral Microbleeds and Global Cognitive Function: The Kashima Scan Study

2015 ◽  
Vol 24 (2) ◽  
pp. 431-439 ◽  
Author(s):  
Yusuke Yakushiji ◽  
Tomoyuki Noguchi ◽  
Andreas Charidimou ◽  
Makoto Eriguchi ◽  
Masashi Nishihara ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Basal Ganglia ◽  
Cerebral Microbleeds ◽  
Global Cognitive Function

Hemichorea-hemiballism and lacunar infarction in the basal ganglia

Neurology ◽  
1981 ◽  
Vol 31 (Issue 4, Part 2) ◽  
pp. 452-455 ◽  
Author(s):  
C. S. Kase ◽  
G. O. Maulsby ◽  
E. deJuan ◽  
J. P. Mohr
Keyword(s):  
Basal Ganglia ◽  
Lacunar Infarction

scholarly journals Does the Somatosensory Temporal Discrimination Threshold Change over Time in Focal Dystonia?

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Antonella Conte ◽  
Gina Ferrazzano ◽  
Daniele Belvisi ◽  
Nicoletta Manzo ◽  
Antonio Suppa ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Cervical Dystonia ◽  
Healthy Subjects ◽  
Temporal Discrimination ◽  
Discrimination Threshold ◽  
Focal Dystonia ◽  
Inhibitory Interneurons ◽  
Follow Up Study ◽  
Over Time

Background. The somatosensory temporal discrimination threshold (STDT) is defined as the shortest interval at which an individual recognizes two stimuli as asynchronous. Some evidence suggests that STDT depends on cortical inhibitory interneurons in the basal ganglia and in primary somatosensory cortex. Several studies have reported that the STDT in patients with dystonia is abnormal. No longitudinal studies have yet investigated whether STDT values in different forms of focal dystonia change during the course of the disease.Methods. We designed a follow-up study on 25 patients with dystonia (15 with blepharospasm and 10 with cervical dystonia) who were tested twice: upon enrolment and 8 years later. STDT values from dystonic patients at the baseline were also compared with those from a group of 30 age-matched healthy subjects.Results. Our findings show that the abnormally high STDT values observed in patients with focal dystonia remained unchanged at the 8-year follow-up assessment whereas disease severity worsened.Conclusions. Our observation that STDT abnormalities in dystonia remain unmodified during the course of the disease suggests that the altered activity of inhibitory interneurons—either at cortical or at subcortical level—responsible for the increased STDT does not deteriorate as the disease progresses.

scholarly journals Diagnosis of Dizziness Due to a Core Vestibular Projection Injury in a Patient with Intracerebral Hemorrhage

Diagnostics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 220 ◽  
Author(s):  
Hyeok Gyu Kwon ◽  
Chul Hoon Chang ◽  
Sung Ho Jang
Keyword(s):  
Basal Ganglia ◽  
Intracerebral Hemorrhage ◽  
Physical Examination ◽  
Left Hemisphere ◽  
Diffusion Tensor ◽  
Insular Cortex ◽  
University Hospital ◽  
The Core ◽  
The University ◽  
Over Time

Herein, we present a patient diagnosed with dizziness due to a core vestibular projection injury following intracerebral hemorrhage (ICH). A 51-year-old female patient underwent conservative management for a spontaneous ICH in the left hemisphere (mainly affecting the basal ganglia and insular cortex). When she visited the rehabilitation department of the university hospital at two years after the ICH onset, she advised of the presence of moderate dizziness (mainly, light-headedness) that started after ICH onset. She mentioned that her dizziness had decreased slightly over time. No abnormality was observed in the vestibular system of either ear on physical examination by an otorhinolaryngologist. However, diffusion tensor tractography results showed that the core vestibular projection in the left hemisphere was discontinued at the basal ganglia level compared with the patient’s right core vestibular projection and that of a normal subject. Therefore, it appears that the dizziness in this patient can be ascribed to a left core vestibular projection injury.

Hemichorea-hemiballism and lacunar infarction in the basal ganglia

Neurology ◽  
1981 ◽  
Vol 31 (4) ◽  
pp. 452-452 ◽  
Author(s):  
C. S. Kase ◽  
G. O. Maulsby ◽  
E. deJuan ◽  
J. P. Mohr
Keyword(s):  
Basal Ganglia ◽  
Lacunar Infarction
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