Effects of repetitive transcranial magnetic stimulation combined with cognitive training on resting-state brain activity in Alzheimer’s disease

2022 ◽  
pp. 197140092110674
Author(s):  
Yuanyuan Qin ◽  
Fengxia Zhang ◽  
Min Zhang ◽  
Wenzhen Zhu
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Functional Connectivity ◽  
Cognitive Training ◽  
Resting State ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Brain Activity ◽  
Low Frequency ◽  
Frequency Fluctuation ◽  
Real Group

Objectives Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to modulate brain plasticity, but the neural basis has been little addressed. The purpose was to investigate the effects of rTMS on resting-state brain activity in patients with Alzheimer’s disease (AD). Methods Seventeen patients with mild or moderate AD were enrolled and randomly divided into one of the two intervention groups: (1) real rTMS combined with cognitive training (real group, n = 9); (2) sham rTMS with cognitive training (sham group, n = 8). 10 Hz rTMS was used to stimulate the left dorsolateral prefrontal cortex and then the left lateral temporal lobe for 20 min each day for 4 weeks. Each patient underwent neuropsychological assessment and resting-state functional magnetic resonance imaging (rsfMRI) before and after treatment. The fractional amplitude of low frequency fluctuation (fALFF) of rsfMRI data in real group were: (1) compared to sham; (2) correlated with rTMS-induced cognitive alterations. Results Significantly increased fALFF in right cerebellum/declive, left lingual/cuneus and left cingulate gyrus, as well as decreased fALFF in left middle frontal gyrus were found after 10 Hz rTMS, but not after sham stimulation. Using these suprathreshold regions, we found that rTMS increased functional connectivity between the right cerebellum/declive and left precentral/postcentral gyrus. The fALFF increase in left lingual/cuneus and right cerebellum/declive was associated with significant improvement in cognitive function. Conclusions rTMS combined with cognitive training induced increased low frequency fluctuation neural oscillations and functional connectivity in brain regions subserving cognition, suggesting a possible neuronal mechanism of the beneficial effects of rTMS.

scholarly journals Low-Frequency Repetitive Transcranial Magnetic Stimulation Restores Dynamic Functional Connectivity in Subcortical Stroke

2021 ◽  
Vol 12 ◽  
Author(s):  
Yin Qin ◽  
Xiaoying Liu ◽  
Xiaoping Guo ◽  
Minhua Liu ◽  
Hui Li ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Functional Connectivity ◽  
Cognitive Control ◽  
Resting State ◽  
Magnetic Stimulation ◽  
Dwell Time ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Healthy Controls ◽  
Dynamic Functional Connectivity

Background and Purpose: Strokes consistently result in brain network dysfunction. Previous studies have focused on the resting-state characteristics over the study period, while dynamic recombination remains largely unknown. Thus, we explored differences in dynamics between brain networks in patients who experienced subcortical stroke and the effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on dynamic functional connectivity (dFC).Methods: A total of 41 patients with subcortical stroke were randomly divided into the LF-rTMS (n = 23) and the sham stimulation groups (n = 18). Resting-state functional MRI data were collected before (1 month after stroke) and after (3 months after stroke) treatment; a total of 20 age- and sex-matched healthy controls were also included. An independent component analysis, sliding window approach, and k-means clustering were used to identify different functional networks, estimate dFC matrices, and analyze dFC states before treatment. We further assessed the effect of LF-rTMS on dFCs in patients with subcortical stroke.Results: Compared to healthy controls, patients with stroke spent significantly more time in state I [p = 0.043, effect size (ES) = 0.64] and exhibited shortened stay in state II (p = 0.015, ES = 0.78); the dwell time gradually returned to normal after LF-rTMS treatment (p = 0.015, ES = 0.55). Changes in dwell time before and after LF-rTMS treatment were positively correlated with changes in the Fugl–Meyer Assessment for Upper Extremity (pr = 0.48, p = 0.028). Moreover, patients with stroke had decreased dFCs between the sensorimotor and cognitive control domains, yet connectivity within the cognitive control network increased. These abnormalities were partially improved after LF-rTMS treatment.Conclusion: Abnormal changes were noted in temporal and spatial characteristics of sensorimotor domains and cognitive control domains of patients who experience subcortical stroke; LF-rTMS can promote the partial recovery of dFC. These findings offer new insight into the dynamic neural mechanisms underlying effect of functional recombination and rTMS in subcortical stroke.Registration:http://www.chictr.org.cn/index.aspx, Unique.identifier: ChiCTR1800019452.

[P1-370]: AGE-RELATED DIFFERENCES IN THE MODULATION OF RESTING-STATE FUNCTIONAL CONNECTIVITY FOLLOWING REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P402-P403
Author(s):  
Kilian Abellaneda-Perez ◽  
Lídia Vaqué-Alcázar ◽  
Elisabeth Solana ◽  
Didac Vidal-Piñeiro ◽  
Núria Bargallo ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Functional Connectivity ◽  
Resting State ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Resting State Functional Connectivity ◽  
Age Related
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