scholarly journals Relationships between body mass index with oral estradiol dose and serum estradiol concentration in transgender adults undergoing feminising hormone therapy

2020 ◽  
Vol 11 ◽  
pp. 204201882092454
Author(s):  
Brendan J. Nolan ◽  
Adam Brownhill ◽  
Ingrid Bretherton ◽  
Peggy Wong ◽  
Susan Fox ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Hormone Therapy ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Target Range ◽  
Estradiol Valerate ◽  
Consensus Guidelines ◽  
Cross Sectional ◽  
Care Clinic ◽  
Estradiol Concentration

Aim: Feminising hormone therapy with estradiol is used to align an individual’s physical characteristics with their gender identity. Given considerable variations in doses of estradiol therapy administered as gender-affirming hormone therapy (GAHT), we aimed to assess if body mass index (BMI) correlated with estradiol dose/concentration and assess the correlation between estradiol dose and estradiol concentrations. Methods: In a retrospective cross-sectional study, we analysed transgender individuals attending a primary or secondary care clinic in Melbourne, Australia who were prescribed oral estradiol valerate for at least 6 months and had estradiol dose and concentration available. Estradiol concentration was measured by immunoassay. Outcomes were the correlation between estradiol dose and BMI, and estradiol dose and estradiol concentration. Results: Data were available for 259 individuals {median age 25.8 [interquartile range (IQR) 21.9, 33.5] years}. Median duration of estradiol therapy was 24 (15, 33) months. Median estradiol concentration was 328 (238, 434) pmol/l [89 (65, 118) pg/ml] on 6 (4, 8) mg estradiol valerate. Median BMI was 24.7 (21.8, 28.6) kg/m2. There was a weak positive correlation between estradiol dose and estradiol concentration ( r = 0.156, p = 0.012). There was no correlation between BMI and estradiol concentration achieved ( r = −0.063, p = 0.413) or BMI and estradiol dose ( r = 0.048, p = 0.536). Estradiol concentrations were within the target range recommended in consensus guidelines in 172 (66%) individuals. Conclusion: Estradiol dose was only weakly correlated with estradiol concentration, suggesting significant interindividual variability. Prescription of estradiol dose should not be based upon an individual’s BMI, which did not correlate with estradiol concentration achieved. In all, 66% of individuals achieved estradiol concentrations recommended in Australian consensus guidelines with a relatively high oral estradiol dose.

scholarly journals SUN-039 Estradiol Dose and Concentrations in Transfeminine Individuals

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Brendan J Nolan ◽  
Adam Brownhill ◽  
Ingrid Bretherton ◽  
Peggy Wong ◽  
Susan Fox ◽  
...  
Keyword(s):  
Position Statement ◽  
Target Range ◽  
Estradiol Valerate ◽  
Consensus Guidelines ◽  
Cross Sectional ◽  
Care Clinic ◽  
Gender Diverse ◽  
And Gender ◽  
Sectional Analysis ◽  
Estradiol Concentration

Abstract Background: Feminizing hormone therapy with estradiol is used to align an individual’s physical characteristics with their gender identity. Australian expert consensus guidelines (1) recommend targeting estradiol concentrations of 250-600 pmol/L (68-163 pg/mL) based on local cross-sectional data (2). We aimed to establish the proportion of individuals achieving estradiol concentrations in consensus guidelines. Methods: A retrospective cross-sectional analysis was performed of transfeminine individuals attending a primary or secondary care clinic in Melbourne, Australia who were prescribed oral estradiol valerate for at least 6 months and had estradiol dose and concentration available. Estradiol concentration was measured by immunoassay. Outcomes were (1) proportion of individuals achieving target estradiol concentrations and (2) influence of estradiol dose and BMI on estradiol concentrations. Results: 259 individuals (median age 25.8(IQR 21.9,33.5) years)) had data available for analysis. Median duration of estradiol therapy was 24(15,33) months. Median estradiol concentration was 328(238,434) pmol/L (89(65,118) pg/mL) on 6(4,8) mg estradiol valerate. 172 (66%) individuals had estradiol concentrations within the target range recommended in consensus guidelines. 70 (27%) individuals had estradiol concentrations below target, and 17 (7%) above target. There was a weak positive correlation between estradiol dose and estradiol concentration (r=0.156, p=0.012). There was no correlation between BMI and estradiol concentration achieved (r=-0.063, p=0.413). Conclusions: 66% of individuals achieved estradiol concentration recommended in consensus guidelines with a relatively high oral estradiol dose. There was significant interindividual variability. Estradiol concentration should be interpreted in conjunction with clinical features of feminization and weighed against potential risks of escalating estradiol dose. References 1. Cheung AS, Wynne K, Erasmus J, Murray S, Zajac JD. Position statement on the hormonal management of adult transgender and gender diverse individuals. Med J Aust 2019; 211:127-133 2. Angus L, Leemaqz SY, Ooi O, Cundill P, Silberstein N, Locke P, Zajac JD, Cheung AS. Cyproterone acetate or spironolactone in lowering testosterone concentrations for transgender individuals receiving estradiol therapy. Endocr Connect 2019

scholarly journals Prevalence of Thinness among Santal Preschool Children Using New Body Mass Index Cut-Off Points

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Subal Das ◽  
Kaushik Bose
Keyword(s):  
Body Mass Index ◽  
Preschool Children ◽  
Nutritional Status ◽  
Body Mass ◽  
Cross Sectional Study ◽  
High Rate ◽  
Tribal Community ◽  
Community Based ◽  
Cross Sectional ◽  
Purulia District

A community-based cross-sectional study was undertaken to determine the prevalence of undernutrition using body mass index (BMI) among 2–6-year Santal preschool children of Purulia District, West Bengal, India. A total of 251 (116 boys and 135 girls) children from 12 villages were measured. Commonly used indicators, that is, weight, height, and BMI, were used to evaluate the nutritional status. More boys (59.5%) than girls (53.3%), based on BMI, were undernourished. Significant age differences in weight (F=44.29∗∗∗; df=3), height (F=58.48∗∗∗; df=3), and BMI (F=3.52∗∗∗; df=3) among boys were observed. Similarly, significant differences between ages in mean weight (F=56.27∗∗∗; df=3), height (F=64.76∗∗∗; df=3), and BMI (F=2.62∗∗∗; df=3) were observed among the girls. The present study revealed that the nutritional status of the preschool children of Santal tribal community of these villages was poor with very high rate of thinness in boys and girls (59.5% and 53.3%, resp.).

Effect modification of cardiorespiratory fitness, obesity, and physical activity in adults

2021 ◽  
Author(s):  
Maria do Socorro Simoes ◽  
Fernando Wehrmeister ◽  
Marcello Romiti ◽  
Antonio de Toledo Gagliardi ◽  
Rodolfo Arantes ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
Vigorous Physical Activity ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Effect Modification ◽  
Cross Sectional ◽  
Arterial Blood

We investigated if cardiorespiratory fitness modifies the association between obesity and the level of physical activity. In this cross-sectional study, we analyzed data from 746 adults, free of diagnosed cardiorespiratory or locomotor diseases. We analyzed sociodemographic and clinical information, cardiovascular risk factors, cardiorespiratory fitness, anthropometry, and level of physical activity (time spent in moderate-to-vigorous physical activity). Those that spent more time in moderate-to-vigorous physical activity were younger, male, with lower body mass index, without self-reported arterial blood hypertension, diabetes and dyslipidemia, non-smokers, and presented with better cardiorespiratory fitness. The linear regression coefficients showed that cardiorespiratory fitness changes according to the level of physical activity and body mass index (obesity in low cardiorespiratory fitness: β 6.0, p = 0.213, 95%CI -3.5 to 15.6; in intermediate cardiorespiratory fitness: β 6.3, p = 0.114, 95%CI -1.5 to 14.2; in high cardiorespiratory fitness: β -6.3, p = 0.304, 95%CI -18.4 to 5.8). This effect modification trend was present after adjusting the model by covariates. Cardiorespiratory fitness potentially modifies the association between body mass index and the level of physical activity. It should be routinely assessed to identify persons with overweight/ obesity with low/ intermediate cardiorespiratory fitness to prescribe individualized training.

Sign in / Sign up

Export Citation Format

Share Document