scholarly journals Pneumonia and inflammation in acute decompensated heart failure: a registry-based analysis of 1939 patients

2017 ◽  
Vol 7 (4) ◽  
pp. 362-370 ◽  
Author(s):  
Alexander Jobs ◽  
Ronja Simon ◽  
Suzanne de Waha ◽  
Kyrill Rogacev ◽  
Alexander Katalinic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hospital Mortality ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
Prognostic Impact ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
All Cause Mortality

Background: The prognostic impact of pneumonia and signs of systemic inflammation in patients with acute decompensated heart failure (ADHF) has not been fully elucidated yet. The aim of the present study was thus to investigate the association of pneumonia and the inflammation surrogate C-reactive protein with all-cause mortality in patients admitted for ADHF. Methods: We analysed data of 1939 patients admitted for ADHF. Patients were dichotomised according to the presence or absence of pneumonia. The primary endpoint of all-cause mortality was determined by death registry linkage. Results: In total, 412 (21.2%) patients had concomitant pneumonia. Median C-reactive protein levels were higher in patients with compared to patients without pneumonia (24.9 versus 9.8 mg/l, respectively; P<0.001). All-cause mortality was significantly higher in patients with pneumonia ( P<0.001). In adjusted Cox regression models, pneumonia as well as C-reactive protein were independently associated with in-hospital mortality. Only C-reactive protein remained as independent predictor for long-term mortality. Conclusion: Pneumonia is relatively common in ADHF and a predictor for in-hospital mortality. However, inflammation in general seems to be more important than pneumonia itself for long-term prognosis. Compared to community-acquired pneumonia studies, C-reactive protein levels were rather low and therefore pneumonia might be over-diagnosed in ADHF patients.

scholarly journals C-REACTIVE PROTEIN IN ACUTE DECOMPENSATED HEART FAILURE: INSIGHTS FROM ASCEND-HF

2013 ◽  
Vol 61 (10) ◽  
pp. E632
Author(s):  
Andreas P. Kalogeropoulos ◽  
Javed Butler ◽  
Amy Hsu ◽  
G. Michael Felker ◽  
Adrian Hernandez ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein to distinguish pneumonia from acute decompensated heart failure

2009 ◽  
Vol 42 (16-17) ◽  
pp. 1628-1634 ◽  
Author(s):  
Erel Joffe ◽  
Dan Justo ◽  
Noa Mashav ◽  
Michael Swartzon ◽  
Hanan Gur ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Delirium is associated with high mortality in older adult patients with acute decompensated heart failure

2020 ◽  
Author(s):  
Misun Pak ◽  
Masahiko Hara ◽  
Shoko Miura ◽  
Motohide Furuya ◽  
Masatake Tamaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Older Adult ◽  
High Mortality ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
Adult Patients ◽  
Prognostic Impact ◽  
Clinical Frailty Scale ◽  
All Cause Mortality

Abstract Background: Delirium is associated with high mortality after cardiac surgery. However, evidence on the epidemiology of delirium in patients with acute decompensated heart failure (ADHF) is limited. This study aimed to assess the incidence and prognostic impact of delirium in patients with ADHF.Methods: This single-center prospective observational study enrolled 132 consecutive patients with ADHF. We utilized the Diagnostic and Statistical Manual of Mental Disorders, fifth edition and classified the patients into two groups according to the presence or absence of delirium. The primary endpoint was 90-day all-cause mortality. The prognostic impact and risk factors of delirium were evaluated using multivariable Cox and logistic regression analyses, respectively. Results: The median patient age was 83 (interquartile range, 75–87) years. Approximately 51.5% were men. Delirium occurred in 36 (27.3%) patients, and hyperactive delirium was the most frequent type (86.1%). The 90-day all-cause mortality was higher in the patients with delirium than in those without (21.6% versus 3.9%, log-rank p=0.002). Delirium was associated with higher mortality with an adjusted hazard ratio of 6.8 (95% confidence interval, 1.1–42.6, p=0.042). The risk factors associated with delirium included advanced age, male sex, higher clinical frailty scale score, and dementia.Conclusions: Delirium was associated with a higher 90-day all-cause mortality in the older adult patients with ADHF. Hyperactive delirium was the most common subtype.

scholarly journals Delirium is Associated with High Mortality in Elderly patients with Acute Decompensated Heart Failure

2020 ◽  
Author(s):  
Misun Pak ◽  
Masahiko Hara ◽  
Shoko Miura ◽  
Motohide Furuya ◽  
Masatake Tamaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Elderly Patients ◽  
High Mortality ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
The Elderly ◽  
Prognostic Impact ◽  
Clinical Frailty Scale ◽  
All Cause Mortality

Abstract Background: Delirium is associated with high mortality after cardiac surgery. However, evidence on the epidemiology of delirium in patients with acute decompensated heart failure (ADHF) is limited. This study aimed to assess the incidence and prognostic impact of delirium in patients with ADHF.Methods: This single-center prospective observational study enrolled 132 consecutive patients with ADHF. We utilized the Diagnostic and Statistical Manual of Mental Disorders, fifth edition and classified the patients into two groups according to the presence or absence of delirium. The primary endpoint was 90-day all-cause mortality. The prognostic impact and risk factors of delirium were evaluated using multivariable Cox and logistic regression analyses, respectively. Results: The median patient age was 83 (interquartile range, 75–87) years. Approximately 51.5% were men. Delirium occurred in 36 (27.3%) patients, and hyperactive delirium was the most frequent type (86.1%). The 90-day all-cause mortality was higher in the patients with delirium than in those without (21.6% versus 3.9%, log-rank p=0.002). Delirium was associated with higher mortality with an adjusted hazard ratio of 6.8 (95% confidence interval, 1.1–42.6, p=0.042). The risk factors associated with delirium included advanced age, male sex, higher clinical frailty scale score, and dementia.Conclusions: Delirium was associated with a higher 90-day all-cause mortality in the elderly patients with ADHF. Hyperactive delirium was the most common subtype.

Troponin T, but not high-sensitivity C-reactive protein, predicts outcomes in patients hospitalized with acute decompensated heart failure

2003 ◽  
Vol 9 (5) ◽  
pp. S90 ◽  
Author(s):  
Maria I. Sosa Liprandi ◽  
Alvaro Sosa Liprandi ◽  
Alejandro Barbagelata ◽  
Marta Garcia Ben ◽  
Claudia Latorraga ◽  
...  
Keyword(s):  
Heart Failure ◽  
Troponin T ◽  
Acute Decompensated Heart Failure ◽  
High Sensitivity ◽  
Decompensated Heart Failure ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Delirium is associated with high mortality in elderly patients with acute decompensated heart failure

2020 ◽  
Author(s):  
Misun Pak ◽  
Masahiko Hara ◽  
Shoko Miura ◽  
Motohide Furuya ◽  
Masatake Tamaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Elderly Patients ◽  
High Mortality ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
The Elderly ◽  
Prognostic Impact ◽  
Clinical Frailty Scale ◽  
All Cause Mortality

Abstract Background: Delirium is associated with high mortality after cardiac surgery. However, evidence on the epidemiology of delirium in patients with acute decompensated heart failure (ADHF) is limited. This study aimed to assess the incidence and prognostic impact of delirium in patients with ADHF. Methods: This single-center prospective observational study enrolled 132 consecutive patients with ADHF. We utilized the Diagnostic and Statistical Manual of Mental Disorders, fifth edition and classified the patients into two groups according to the presence or absence of delirium. The primary endpoint was 90-day all-cause mortality. The prognostic impact and risk factors of delirium were evaluated using multivariable Cox and logistic regression analyses, respectively. Results: The median patient age was 83 (interquartile range, 75–87) years. Approximately 51.5% were men. Delirium occurred in 36 (27.3%) patients, and hyperactive delirium was the most frequent type (86.1%). The 90-day all-cause mortality was higher in the patients with delirium than in those without (21.6% versus 3.9%, log-rank p=0.002). Delirium was associated with higher mortality with an adjusted hazard ratio of 6.8 (95% confidence interval, 1.1–42.6, p=0.042). The risk factors associated with delirium included advanced age, male sex, higher clinical frailty scale score, and dementia. Conclusions: Delirium was associated with a higher 90-day all-cause mortality in the elderly patients with ADHF. Hyperactive delirium was the most common subtype.

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