scholarly journals Keloidal pathophysiology: Current notions

2021 ◽  
Vol 7 ◽  
pp. 205951312098032
Author(s):  
Chenyu Huang ◽  
Rei Ogawa
Keyword(s):  
Web Of Science ◽  
English Literature ◽  
The Body ◽  
Mechanical Forces ◽  
Healthy Skin ◽  
Level Of Evidence ◽  
Extracellular Matrix Components ◽  
Keloid Formation ◽  
Mechanical Factors ◽  
Pathological Scar

Introduction: Keloids are pathological scars that are notorious for their chronic and relentless invasion into adjacent healthy skin, with commonly seen post-therapeutic recurrence after monotherapies. Methods: An English literature review on keloid pathophysiology was performed by searching the PubMed, Embase and Web of Science databases, to find out the up-to-date relevant articles. The level of evidence was evaluated based on the included studies with the highest level of evidence first. Results: Keloid morphology, signs, symptoms and the histopathological changes that occur in the local cells and extracellular matrix components are described. The theories on the pathophysiology of keloidogenesis that have been proposed to date are also covered; these include endocrinological, nutritional, vascular, and autoimmunological factors. In addition, we describe the local mechanical forces (and the mechanosignalling pathways by which these forces shape keloid cell activities) that promote keloid formation and determine the direction of invasion of keloids and the body sites that are prone to them. Conclusion: A better understanding of this pathological entity, particularly its mechanobiology, will aid the development of new diagnostic and therapeutic strategies for use in the clinic to prevent, reduce or even reverse the growth of this pathological scar. Lay Summary Keloids are skin scars that are famous for their chronic invasion into healthy skin, with commonly seen recurrence after surgeries. Cells such as lymphocytes, macrophages, mast cells and endothelial cells are involved in keloid growth. Particularly, endocrinological, nutritional, vascular, autoimmunological and mechanical factors actively take part in keloid progression.

Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis

2020 ◽  
Author(s):  
Shamim Mushtaq
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Web Of Science ◽  
The Body ◽  
Main Role ◽  
Hallmarks Of Cancer ◽  
Cyclin Dependent Kinases ◽  
Tumor Studies ◽  
Cycle Regulation

Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are frequently down regulated or up regulated in various cancers. Two CDK family members, CDK 11 and 12, have contradicting views about their roles in different cancers. For example, one study suggests that the CDK 11 isoforms, p58, inhibits growth of breast cancer whereas, the CDK 11 isoform, p110, is highly expressed in breast tumor. Studies regarding CDK 12 show variation of opinion towards different parts of the body, however there is a consensus that upregulation of cdk12 increases the risk of breast cancer. Hence, CDK 11 and CDK 12 need to be analyzed to confirm their mechanism and their role regarding therapeutics, prognostic value, and ethnicity in cancer. This article gives an outline on both CDKs of information known up to date from Medline, PubMed, Google Scholar and Web of Science search engines, which were explored and thirty relevant researches were finalized.

Cannabis Associated “High” Cardiovascular Morbidity and Mortality: Marijuana Smoke Like Tobacco Smoke? A Déjà Vu/Déjà Vécu Story?

2019 ◽  
Vol 19 (11) ◽  
pp. 870-879 ◽  
Author(s):  
Theodora A. Manolis ◽  
Antonis A. Manolis ◽  
Antonis S. Manolis
Keyword(s):  
Health Effects ◽  
Tobacco Use ◽  
Tobacco Smoking ◽  
English Literature ◽  
The Body ◽  
Cannabis Use ◽  
Cardiovascular Morbidity And Mortality ◽  
Cannabis Smoking ◽  
Deja Vu ◽  
Déjà Vu

Background: Cannabis use has increased over the past several years as some countries have legalized its use for the treatment of certain medical conditions and/or for recreational use. Thus, concerns have risen about potential adverse health effects. Increasing number of reports have associated cannabis use with serious cardiovascular (CV) complications. Furthermore, there appears to be a likeness in the harmful health effects, especially on the CV and respiratory systems, of cannabis smoking to those of tobacco smoking. Objective: To review the CV effects of cannabis use and compare them with those of tobacco use. Methods: Articles were reviewed that were published in English literature reporting on cannabis and cannabinoid pharmacology and their effects on the CV system and their consequences. Emphasis was also placed on articles reporting on cannabis use in adolescents, exposure to secondhand smoke, its effect on exercise and finally its inter-relationship and similarities with tobacco use. Results: With growing cannabis use, an increasing number of reports have emerged associating marijuana use with serious and life-threatening CV complications, including acute coronary syndromes, potentially lethal cardiac arrhythmias and ischemic strokes. There are certain similarities of the deleterious CV and respiratory effects of cannabis smoking with those of tobacco smoking. Despite the difference in the active ingredients (tetrahydrocannabinol vs. nicotine), each substance produces a plethora of chemicals when smoked and these are largely identical; furthermore, due to different modes of smoking, cannabis chemicals are retained in the body for a longer time. Of course, concomitant tobacco and cannabis smoking is a perplexing factor in isolating damages specifically pertaining to cannabis use, while the health risk is additive. Although the mechanisms producing CV harm may be somewhat different between these two substances, the outcome appears similar, or even worse, as the effects may emerge at a younger age. Conclusion: There is an increasing concern that, apart from the mental health problem with cannabis smoking, societies may be facing another wave of a déjà vu/déjà vécu phenomenon similar to the tobacco smoking story.

The physical basis of mollusk shell chiral coiling

2021 ◽  
Vol 118 (48) ◽  
pp. e2109210118
Author(s):  
Régis Chirat ◽  
Alain Goriely ◽  
Derek E. Moulton
Keyword(s):  
Mathematical Model ◽  
The Body ◽  
Symmetric Body ◽  
Model Organisms ◽  
Physical Interaction ◽  
Mechanical Forces ◽  
Hard Shell ◽  
Left Right Asymmetry ◽  
Development And Evolution ◽  
Mollusk Shell

Snails are model organisms for studying the genetic, molecular, and developmental bases of left–right asymmetry in Bilateria. However, the development of their typical helicospiral shell, present for the last 540 million years in environments as different as the abyss or our gardens, remains poorly understood. Conversely, ammonites typically have a bilaterally symmetric, planispiraly coiled shell, with only 1% of 3,000 genera displaying either a helicospiral or a meandering asymmetric shell. A comparative analysis suggests that the development of chiral shells in these mollusks is different and that, unlike snails, ammonites with asymmetric shells probably had a bilaterally symmetric body diagnostic of cephalopods. We propose a mathematical model for the growth of shells, taking into account the physical interaction during development between the soft mollusk body and its hard shell. Our model shows that a growth mismatch between the secreted shell tube and a bilaterally symmetric body in ammonites can generate mechanical forces that are balanced by a twist of the body, breaking shell symmetry. In gastropods, where a twist is intrinsic to the body, the same model predicts that helicospiral shells are the most likely shell forms. Our model explains a large diversity of forms and shows that, although molluscan shells are incrementally secreted at their opening, the path followed by the shell edge and the resulting form are partly governed by the mechanics of the body inside the shell, a perspective that explains many aspects of their development and evolution.

Preparation of skin care product using coccinia abyssinica tuber extract

2021 ◽  
Author(s):  
Mulugeta Berhanu
Keyword(s):  
Extraction Method ◽  
Skin Care ◽  
The Body ◽  
Healthy Skin ◽  
Care Product ◽  
Skin Cream ◽  
Skin Care Product ◽  
Thickening Agents ◽  
Tuber Extract ◽  
New Skin

Abstract Anchote (Coccinia abyssinica) is highly nutritious crop which is mostly cultivated in Wollega Zone, Oromia Regional State of Ethiopia. Anchote tubers are rich in calcium and starch which are essential for healthy skin. Thus, a new skin cream was formulated using coccinia abyssinica tuber extract for the purpose of moistening and nourishing the skin. Coccinia abyssinica tuber extract was prepared by maceration extraction method. Then, tuber extract of coccinia abyssinica was mixed with ingredients such as thickening agents, humectant, emollient, antioxidant, preservatives and fragrance to prepare a new skin cream. A newly prepared skin care product was applied to the human skin. The skin became soft, attractive and supple after using this new skin cream. It didn’t cause any side effects on the human body. The current study revealed that coccinia abyssinica skin care product enrich the body with nutrients and useful minerals.

Chondroma of the external auditory canal

1998 ◽  
Vol 112 (3) ◽  
pp. 278-279 ◽  
Author(s):  
I. J. M. Johnson ◽  
M. H. Tadpatrikar ◽  
J. F. Sharp
Keyword(s):  
External Auditory Canal ◽  
English Literature ◽  
The Body ◽  
Benign Tumour ◽  
Anatomical Site

AbstractChondroma, a benign tumour which is common at many sites in the body, has not been reported in the English literature in the bony external auditory canal. The first such case at this anatomical site is described and the pathogenesis is considered.

scholarly journals Factors Affecting the Number of Citations to Clinical Therapeutic Articles Mentioning Level of Evidence

2020 ◽  
Vol 17 (2) ◽  
Author(s):  
Hossein Beydokhti ◽  
Nosrat Riahinia ◽  
Hamid R Jamali ◽  
Saeid Asadi ◽  
Seyed Mohammad Riahi
Keyword(s):  
Web Of Science ◽  
Pearson Correlation ◽  
Background Level ◽  
Clinical Papers ◽  
Level Of Evidence ◽  
Factors Affecting ◽  
Article Type ◽  
Pearson Correlation Test ◽  
Level I ◽  
Number Of Citations

Background: Level of evidence (LoE) is a hierarchical system for classifying the quality of studies. Objectives: This study examined the factors affecting the number of citations to clinical articles related to the treatment of human diseases that have included the LoE in their abstracts. Methods: A total of 3,683 therapeutic articles published between 2011 and 2013 that mentioned the LoE in their abstract and were indexed in PubMed and Web of Science were retrieved. The LoE and type of study design were extracted from abstracts and other bibliographic and citation information was obtained from PubMed and Web of Science databases. Independent samples t-test, one-way ANOVA, Pearson correlation test and linear regression were used to analyze the relationship between the variables. Results: Articles with level I evidence had the lowest frequency (290, 7.9%) and articles with level IV had the highest frequency (1,831, 49.7%). Five-year citations ranged from zero to 215, with a median of 13 citations. The median values of five-year citations from level I to level V were 20.5, 15, 14, 11, and 6 citations, respectively. Evaluation of the models to examine the factors affecting the number of citations showed that the change of evidence-level from level I to V reduced the number of citations (P < 0.001). Conclusions: Journal Impact Factor, LoE, number of references, number of authors, number of title words, number of pages, article type and subject category accounted for about 25% of the variation in five-year citations of clinical papers. Clinical papers with high LoE (levels I & II) received more citations over a five-year period than those with lower LoE (levels III & IV).

Positioning and maintenance of embryonic body wall muscle attachments in C. elegans requires the mup-1 gene

Development ◽  
1991 ◽  
Vol 111 (3) ◽  
pp. 667-681 ◽  
Author(s):  
P.Y. Goh ◽  
T. Bogaert
Keyword(s):  
Extracellular Matrix ◽  
Body Wall ◽  
Early Stage ◽  
Muscle Growth ◽  
The Body ◽  
Body Wall Muscle ◽  
C Elegans ◽  
Extracellular Matrix Molecule ◽  
Extracellular Matrix Components ◽  
Body Wall Muscles

As part of a general study of genes specifying a pattern of muscle attachments, we identified and genetically characterised mutants in the mup-1 gene. The body wall muscles of early stage mup-1 embryos have a wild-type myofilament pattern but may extend ectopic processes. Later in embryogenesis, some body wall muscles detach from the hypodermis. Genetic analysis suggests that mup-1 has both a maternal and a zygotic component and is not required for postembryonic muscle growth and attachment. mup-1 mutants are suppressed by mutations in several genes that encode extracellular matrix components. We propose that mup-1 may encode a cell surface/extracellular matrix molecule required both for the positioning of body wall muscle attachments in early embryogenesis and the subsequent maintenance of these attachments to the hypodermis until after cuticle synthesis.

EFFECT OF SPORTS MEDICINE ON REDUCING BODY FAT PERCENTAGE AND LEAN BODY MASS

2021 ◽  
Vol 27 (7) ◽  
pp. 714-717
Author(s):  
Chunyan Fan
Keyword(s):  
Aerobic Exercise ◽  
Body Fat ◽  
Exercise Performance ◽  
Performance Indicators ◽  
Sports Medicine ◽  
The Body ◽  
Anaerobic Exercise ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Level Of Evidence

ABSTRACT Introduction: Aerobic exercise has begun to be widely recognized as a reasonable means of preventing fat and losing weight. Scholars have confirmed that sports can help the human body lose weight and lose fat. Objective: This article measures the exercise performance indicators of subjects in different body fat percentage groups and studies the relationship between body fat percentage and exercise performance indicators. Methods: The study uses experimental methods to determine the percentage of body fat of the subjects. After physical exercise and aerobic exercise, the volunteers were tested for aerobic capacity indicators. Results: The body fat percentage of physically inactive persons was negatively correlated with aerobic and anaerobic exercise capacity indexes. Conclusion: The mechanism of aerobic exercise in weight loss treatment has the effect of promoting lipolysis and regulating blood lipid metabolism. At the same time, it has a significant influence on the number and activity of fat cells. Level of evidence II; Therapeutic studies - investigation of treatment results.

Predictors of Pain, Function, and Change in Patellofemoral Pain

2019 ◽  
Vol 48 (2) ◽  
pp. 351-358 ◽  
Author(s):  
Alexandra Hott ◽  
Jens Ivar Brox ◽  
Are Hugo Pripp ◽  
Niels Gunnar Juel ◽  
Sigurd Liavaag
Keyword(s):  
Global Change ◽  
Self Efficacy ◽  
Controlled Trial ◽  
Change Score ◽  
Patellofemoral Pain ◽  
The Body ◽  
Level Of Evidence ◽  
Change Scores ◽  
Poor Outcome ◽  
Pain Duration

Background: Identification of factors predictive of outcome and change is important to improve treatment for patellofemoral pain (PFP). Few studies have examined the predictive value of psychological factors in PFP, although they have been reported to be important predictors in other musculoskeletal pain conditions. Purpose: To evaluate predictors of pain, function, and change 1 year after an exercise-based intervention in PFP. Study Design: Cohort study; Level of evidence, 3. Methods: In sum, 112 patients were recruited to a randomized controlled trial; 98 attended 1-year follow-up. There were no between-group differences in the trial; thus, the material was analyzed as 1 cohort. Nine baseline factors—sex, bilateral pain, worst pain, pain duration, Anterior Knee Pain Scale (AKPS), kinesiophobia, anxiety and depression, self-efficacy, and number of pain sites throughout the body—were investigated for their predictive ability on outcome at 1 year (AKPS, worst pain) and for change at 1 year (global change score, change in AKPS, and change in worst pain). Multivariable linear regression models with stepwise backward removal method were used to find predictors of poor outcome. Results: Number of pain sites at baseline was a significant predictor of worse outcome for AKPS ( B = −2.7; 95% CI, –4.0 to −1.3; P < .01), worst pain ( B = 0.5; 95% CI, 0.2-0.8; P < .01), global change ( B = −0.8; 95% CI, –1.2 to −0.5; P < .01), change in AKPS ( B = −2.7; 95% CI, –4.0 to −1.3; P < .01), and change in worst pain ( B = 0.5, 95% CI, 0.2-0.8; P < .01) at 1 year. Baseline scores for AKPS and worst pain predicted respective 1-year levels and change scores ( P < .01). Lower self-efficacy and male sex predicted less global change ( P < .01). Longer pain duration predicted final score and change score for worst pain ( P < .01). The predictive models had reasonable fit with adjusted R2 from 0.22 to 0.35. Conclusion: Higher number of pain sites throughout the body was a consistent predictor of poor outcome and less change at 1 year. Baseline levels for AKPS and worst pain predicted respective final scores and change scores. Registration: NCT02114294 ( ClinicalTrials.gov identifier).

Treatment protocol and effectiveness of cosmeceuticals in aesthetic practice

2020 ◽  
Vol 9 (4) ◽  
pp. 148-153
Author(s):  
Lucy Millar-Hume
Keyword(s):  
Antibiotic Resistance ◽  
Biological Effect ◽  
Treatment Protocol ◽  
Antibiotic Use ◽  
The Body ◽  
Level Of Evidence ◽  
Physiological Functions ◽  
Drug Products ◽  
Aesthetic Practice ◽  
Oral Isotretinoin

Pharmaceuticals are essentially drug products containing active ingredients that prevent, mitigate, treat disease and/or affect the anatomy or physiological functions of the body. Cosmeceuticals is a term blending the meaning and action of pharmaceuticals and cosmetics, resulting in a product that cannot exert a biological effect on cells, but can nonetheless improve the quality and condition of the skin. Traditional medical methods of treating acne centre around antibiotic use and oral isotretinoin. Antibiotic resistance is a growing problem, and it means aesthetic practitioners must find alternatives. Attention is turning to cosmeceuticals as a solution, but this raises the question of the level of evidence for their growing use.

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