scholarly journals Central Defect Type Partıal ACL Injury Model on Goat Knees

2014 ◽  
Vol 2 (11_suppl3) ◽  
pp. 2325967114S0011
Author(s):  
Bekir Karakılıç ◽  
Emin Taşkıran ◽  
Başak Doğanavşargil ◽  
Salih Çelik
Keyword(s):  
Statistical Significance ◽  
Acl Injury ◽  
Type I ◽  
Fat Pad ◽  
Defect Type ◽  
Group I ◽  
Injury Model ◽  
Defect Area ◽  
Central Defect ◽  
Group Ii

Objectives: The aim of this study is to investigate the primary healing capacity of the anterior cruciate ligament (ACL) and the possible effect of fat pad excision on it. For this purpose, a central defect type ACL injury model was performed. Histopathological and biomechanical studies were performed on this model. Methods: Total of ten female adolescent Anatolian Black Goats were included in the study. A midsubstance central defect was created successfully with a four mm. arthroscopic punch in the ACLs of right knees of all the subjects through a medial mini-arthrotomy and goats were assigned to groups whether the fat pad was preserved (group I, n=5) or excised completely (group II, n=5). The left knees served as control. The histopathological evaluations of the defect area were performed utilizing Hematoxylene-Eosine, Masson Trichrome, Van Gieson, and elastic Van Gieson staining as well as measurement of type I collagen immunohistochemically in one sample from each group at 10th week postoperatively. The remaining knees were evaluated biomechanically at the 12th week, measuring anterior tibial translation (ATT) of the knee joints at 90 degrees of flexion and tensile properties (Maximum Tensile Load (MTL), Maximum Elongation (ME), Stiffness (S), failure mode (FM)) of the femur-ACL-tibia complex. Statistical analysis was performed utilizing SPSS v18 package program. Mann – Whitney U and Wilcoxon’s signed rank test were used for inter and intragroup analysis, respectively. Statistical significance was set at 0.05. Results: Histopathological analysis revealed that the central defect area was fully filled macroscopically and microscopically. However, mucoid degeneration was observed in group II. Relative collagen type I content increased in group II. There was no significant difference both within and between groups in terms of ATT values (p=0.715 and p=0.149 respectively). There was no statistical significance between and within groups in terms of MTL and ME; however group II demonstrated greater stiffness than group I (p=0,043) Overall (n=16 knees), tibial avulsion was the commonest mode of failure (n=9) in both control and operated knees. Conclusion: These findings revealed that the central defect type partial ACL injury model acted stable on A-P direction and had full healing capacity. The excision of the fat-pad had no additional effect except increased stiffness. Tibial insertion site seemed to be the weakest portion of the femur-ACL-tibia complex in adolescent goat knees.

scholarly journals Central defect type partial ACL injury model on goat knees: the effect of infrapatellar fat pad excision

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Bekir Karakilic ◽  
Emin Taskiran ◽  
Basak Doganavsargil ◽  
Bora Uzun ◽  
Salih Celik ◽  
...  
Keyword(s):  
Acl Injury ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Defect Type ◽  
Injury Model ◽  
Central Defect

Comparison of a PGA Sheet with a Commercial ePTFE Sheet as a Staple-Line Reinforcement in Lung Surgery

2007 ◽  
Vol 342-343 ◽  
pp. 849-852
Author(s):  
Keon Hyeon Jo ◽  
Seok Whan Moon ◽  
Young Du Kim ◽  
Young Jo Sa ◽  
Si Young Choi ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Polyglycolic Acid ◽  
Lung Surgery ◽  
Resection Margins ◽  
Air Leakage ◽  
Staple Line Reinforcement ◽  
Group I ◽  
Significant Difference ◽  
Similar Threshold ◽  
Group Ii

To prevent prolonged air leakage after lung surgery, we developed a biodegradable polyglycolic acid (PGA) sheet and compared it with an expanded polytetrafluoethylene (ePTFE). Eighteen adult mongrel dogs were used in this experiment. The airway pressures at which air first leaked at the stapled resection margins were measured immediately after surgery in group I (N=5), 2 days after surgery in group II (N=5), and 7 days after surgery in group IIII (N=5), Based on the presence of SLR, there were 3 subgroups in each group: there was no SLR in subgroup a; ePTFE in subgroup b; PGA sheet in subgroup c. The histologic examination was performed 2 months after surgery (N=3). In group I, there was a significant difference in air leakage pressures (mm Hg) between no reinforcement and SLR. We observed the same results in group II and III with statistical significance. However, there was no significant difference between the reinforcement groups. The histologic findings demonstrated more severe adhesions and biodegradation in the dogs in which the PGA sheet was used. Our PGA sheet was considered a useful reinforcement material, because it had a similar threshold for air leakage with the ePTFE with excellent biodegradation.

Ventilation and thoracoabdominal asynchrony during halothane anesthesia in infants

1993 ◽  
Vol 74 (4) ◽  
pp. 1591-1596 ◽  
Author(s):  
M. Benameur ◽  
M. D. Goldman ◽  
C. Ecoffey ◽  
C. Gaultier
Keyword(s):  
Tidal Volume ◽  
Minute Ventilation ◽  
Statistical Significance ◽  
Age Group ◽  
Halothane Anesthesia ◽  
Minimal Alveolar Concentration ◽  
Group I ◽  
Wall Compliance ◽  
Group Ii ◽  
Thoracoabdominal Asynchrony

To evaluate the ventilatory consequences of high chest wall compliance during anesthesia in infants, we assessed the effects of halothane at different fractions of minimal alveolar concentration (0.75, 1.0, and 1.5 MAC) on ventilation and movements of the rib cage and abdomen in infants < or = 12 mo of age (group I) and children (group II) > or = 12 mo of age. Minute ventilation decreased in group I, (20.6%, 0.75 to 1.5 MAC), but the change in group II did not reach the level of statistical significance. Tidal volume decreased with halothane level between 0.75 and 1.5 MAC, and its fall was greater in group I (32.7 +/- 11.2 vs. 22.6 +/- 9.3% in group II, P < 0.05). Duty cycle, or ratio of inspiratory to total time (TI/TT), increased in group II with halothane level but did not change in group I, resulting in a decreased TI in group I at higher halothane levels. Thoracic paradox increased with halothane level in group I but not group II. The increase in thoracic paradox in association with the fall in tidal volume between 0.75 and 1.5 MAC was greater in group I than group II (P < 0.05). We conclude that smaller infants depend more on inspiratory intercostal muscle activity to stabilize the thorax, leading to a greater degree of depression of ventilation during halothane depression of inspiratory intercostal activity.

scholarly journals Education in plastic surgery: Are we headed in the right direction?

2014 ◽  
Vol 47 (01) ◽  
pp. 109-115 ◽  
Author(s):  
Nishant Khare ◽  
Vinita Puri
Keyword(s):  
Plastic Surgery ◽  
Statistical Significance ◽  
Maxillofacial Surgery ◽  
Aesthetic Surgery ◽  
Microvascular Surgery ◽  
Chi Square ◽  
Surgery Group ◽  
Group I ◽  
Group Ii ◽  
And Training

ABSTRACT Introduction: Plastic surgery in India is in an era of transition. The speciality faces many challenges as it grows. The present study attempts to identify these challenges and the prevalent mood among the teachers and the trainees. Materials and Methods: The study was conducted from September 2011 to June 2012. In an E-mail based survey a questionnaire was mailed to professionals actively involved in teaching and training of residents in plastic surgery in many institutes running MCh courses in plastic surgery (Group I) [Appendix 1]. Another questionnaire was mailed to residents undergoing training in plastic surgery and those who had completed their training within past 2 years (Group II) [Appendix 2]. Chi-square test was applied to test for statistical significance. Observations: 29 Group I and 33 Group II subjects responded to the questionnaire. While 72.4% teachers believed that the current system is producing plastic surgeons with enough skill level, only 9.1% of the respondents in Group II thought the same (Chi-square = 28.1; df = 2; P < 0.001). Whereas 58.6% Group I respondents thought that their student is sufficiently equipped to compete in today’s scenario [Figure 1], only 18.2% Group II respondents thought that their training is enough [Figure 2]. (Chi-square = 16.4; df = 2; P < 0.001). Nearly 28% respondents in Group I and only 3% in Group II thought that scientific research and publications should be made mandatory for successful completion of plastic surgery training (Chi-square = 9.4; df = 2; P = 0.009). Adequate exposure was thought to be available in general plastic surgery (Group I: 92% Group II: 81%), maxillofacial surgery (Group I: 72% Group II: 68%) and hand surgery (Group I: 84% Group II: 69%). Both groups agreed that exposure is lacking in craniofacial surgery, aesthetic surgery and microvascular surgery. Aesthetic surgery (38.7%) and microvascular surgery (32.6%) were the most frequent response when the Group II respondents were enquired about the subspeciality they would like to focus on in their practice. Inter-departmental exchange of students for limited period of time was favoured by 86.2% of Group I respondents and 93.9% Group II respondents (Chi-square = 1.3; df = 2; P = 0.49). Conclusion: The current training programme is differently perceived by teachers and the trainees. We recommend that constant deliberations at national and regional forums should take place regarding our education and training programmes.

scholarly journals Dietary intake of mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (w/v)

2017 ◽  
Vol 4 (2) ◽  
pp. 409
Author(s):  
ML Edy Parwanto ◽  
Hardy Senjaya
Keyword(s):  
Environmental Factors ◽  
Carbohydrate Intake ◽  
Sex Hormone Binding Globulin ◽  
Anthropometric Measurement ◽  
Type I ◽  
Childbearing Age ◽  
Energy Deficiency ◽  
Group I ◽  
Heterozygous Variant ◽  
Group Ii

Background: Body mass index (BMI) determined by genetic and environmental factors. One of the genetic factors that determine the BMI is a genetic polymorphism of sex hormone binding globulin (SHBG), whereas the intake of nutrients is one of the environmental factors. The objective: investigate to macronutrient intake of mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (W/v).Methods: Anthropometric measurement, genotyping of D327N SHBG gen exon 8, and three days repeated food recall and record was done for all subjects. BMI in the group I 16 to <17 kg/m2 and group II 17 to <18.5 kg/m2. For all subjects in both groups has heterozygous variant D327N SHBG genotype (W/v).Results: mother in chieldbearing age with BMI <18.5 kg/m2 and has heterozygous variant SHBG genotype (W/v) is undernutrition. Seventy two percent of the total subjects including type I of chronic energy deficiency (CED), and 28% as type II of CED. Protein, fat and carbohydrate intake and mid-upper arm circumference (MUAC) in the group I was lower than group II (p<0.05), while muscle mass in the group I did not different compare to group II (p>0.097).Conclusions: Mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotypes (W/v) shows that the lower of protein, fat and carbohydrate intake then CED status is getting low.

scholarly journals Treatment of slipped capital femoral epiphysis - a comparative study during twelve years period

2019 ◽  
Vol 147 (5-6) ◽  
pp. 335-340
Author(s):  
Bojan Bukva ◽  
Sinisa Ducic ◽  
Vladimir Radlovic ◽  
Goran Vrgoc ◽  
Branislav Krivokapic ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Closed Reduction ◽  
Statistical Significance ◽  
Slipped Capital Femoral Epiphysis ◽  
Cannulated Screw ◽  
Cast Immobilization ◽  
Group I ◽  
Before And After ◽  
Group Ii ◽  
Screw Group

Introduction/Objective. The purpose of this study was to compare two methods of treatment and to evaluate the advantages in the final outcome of transcervical fixation of the femoral head using one cannulated screw in the treatment of slipped capital femoral epiphysis. Methods. This study included 65 pediatric patients (35 boys and 30 girls), aged 6?16 years (average 11.86), during a 12-year period (2000?2012). We compared the slipping degree before and after the treatment (Southwick angle), the range of motion before and after treatment, and complication occurrence between two groups of children. The first group of children (26 patients) underwent closed reduction and cast immobilization (Group I). The other group (39 patients) was treated with transcervical fixation using one cannulated screw (Group II). Results. Comparing preoperative and postoperative Southwick angle, we found much better improvement in Group II, but without statistical significance between the two groups of patients (p = 0.09). Observing the range of motion of the hips before and after treatment, we found improvement in both groups of patients, especially in patients treated using transcervical fixation with cannulated screw (Group II). In complication occurrence, the patients in Group II had less complication occurrence compared to Group I (p = 0.02). Conclusion. The transcervical fixation using one cannulated screw has better clinical outcome and lower complication rate in relation to closed reduction and cast immobilization in the treatment of slipped capital femoral epiphysis.

Analysis of risk factors and diseases associated with atherosclerosis in the progression of carotid artery stenosis

Vascular ◽  
2015 ◽  
Vol 24 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Nayara Cioffi Batagini ◽  
Erasmo Simão da Silva ◽  
Carlos AV Pinto ◽  
Pedro Puech-Leão ◽  
Nelson de Luccia
Keyword(s):  
Risk Factors ◽  
Carotid Stenosis ◽  
Statistical Significance ◽  
Carotid Bifurcation ◽  
Inflammatory Factors ◽  
Plasma Urea ◽  
Atherosclerotic Stenosis ◽  
Asymptomatic Patients ◽  
Group I ◽  
Group Ii

Objective The objective of this study was to analyze the roles of demographic, clinical, and laboratory factors on the progression of atherosclerotic stenosis in carotid bifurcation. It was based on prospective information from records entered on a specific application form for follow-up outpatients at a tertiary university service. Methods Consecutive symptomatic and asymptomatic patients ( n = 210) who had undergone more than one carotid duplex scan but no surgical intervention were selected for the analysis. The patients were divided into two groups: patients whose duplex scans did not show bilateral progression of carotid stenosis and patients with carotid stenosis progression of <50%, 50%–69%, or >70%. Clinical and demographic parameters were compared between groups. Results Group II levels of plasma urea (51.6 ± 27.8 mg/dl) and fibrinogen (493.2 ± 113.3 mg/dl) were higher than the Group I levels (43.0 ± 14.9 mg/dl and 441.3 ± 106.7 mg/dl, respectively) with statistical significance (p urea = 0.013 and p fibrinogen = 0.018). Paradoxically, the mean body mass index was higher in Group I (26.4 ± 4.6 kg/m2) than in Group II (24.6 ± 3.9 kg/m2; p = 0.02). Conclusions Traditional risk factors for the development of atherosclerosis in a carotid bifurcation are important but not unique. Metabolic and inflammatory factors can contribute to disease progression.

Effect of Enamel Deproteinization in Primary Teeth

2018 ◽  
Vol 42 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Ananthi Christopher ◽  
R Krishnakumar ◽  
N Venugopal Reddy ◽  
G Rohini
Keyword(s):  
Surface Area ◽  
Group Iv ◽  
Enamel Surface ◽  
Tooth Surface ◽  
Type I ◽  
Group Iii ◽  
Group I ◽  
Electron Microscope Analysis ◽  
Group Ii ◽  
Quality Type

Objective: To evaluate and compare the topographical features of enamel surface, etched with different materials. Study Design: 10 extracted human primary molars were randomly selected and cut and trimmed to 1 mm2. Each group comprised of 10 blocks and the enamel was treated as follows: Group I–35% H3PO4; Group II–5.25% NaOCl + 35% H3PO4 ;Group III–5.25% NaOCl; Group IV no treatment was carried out. All the samples were prepared for Scanning electron microscope analysis. The images were obtained and evaluated for the quality type I–II etching of the enamel surface using Auto-CAD 2011 software. Statistical Analysis Used: Wilcoxon Signed Ranks Test (p&lt;0.001). Results: The mean surface area of type I and II etching pattern values for Group- I was 39608.18 μm2 and Group- II was 45051.34 μm2. Conclusion: Deproteinization with 5.25% Sodium hypochlorite prior to acid etching could be used to increase the surface area of adhesion of composite material with the tooth surface.

Conventional approach to glucose management for diabetic patients undergoing coronary artery bypass surgery

Perfusion ◽  
2002 ◽  
Vol 17 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Patricia A Gustafson ◽  
Debra L Zarro ◽  
David A Palanzo ◽  
Norman J Manley ◽  
Ralph M Montesano ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Insulin Infusion ◽  
Diabetic Patients ◽  
Type I ◽  
Cardioplegic Solution ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Continuous insulin infusion was not an effective mode of treatment in maintaining safe blood glucose levels (<200 mg/dl) during the intraoperative period of diabetic patients requiring open-heart surgery. The two modifications investigated to gain better control of the blood glucose were a change in the base solution of the cardioplegia and the use of a sliding insulin scale. Fifty patients including Type I and Type II diabetics were selected for the purpose of this study. The patients were then randomly divided into two groups categorized by the type of cardioplegic solution administered and the mode of insulin treatment. Group I patients received a dextrose 5%-based cardioplegic solution and blood glucose was treated via continuous intravenous insulin infusion. Group II patients received normal saline 0.9%-based cardioplegic solution and blood glucose was treated via sliding scale. Blood glucose levels were monitored pre- and postcardio- pulmonary bypass (CPB) and every 30 min while on CPB. Glucose values were analyzed by group t test. A p value of < 0.05 was considered statistically significant. When comparing Group I (mean=258 mg/dl) with Group II (mean= 158 mg/dl), there was a statistically significant difference between the glucose values at each of the time intervals when the glucose values were recorded. In conclusion, Group II maintained an acceptable blood glucose level (<200 mg/dl) throughout the entire intra- operative period, which suggests that the combination of the sliding insulin scale and modification of the base cardioplegic solution was an effective mode of treatment.

scholarly journals Cardiovascular Pathology – a Factor of the Adverse Course of Diabetic Polyneuropathy

2021 ◽  
pp. 28-33
Author(s):  
Hennadii Chupryna ◽  
Viktoriia Dubynetska ◽  
Kateryna Kachur
Keyword(s):  
Peripheral Nerves ◽  
Clinical Manifestations ◽  
Diabetic Polyneuropathy ◽  
Neurological Status ◽  
Type I ◽  
Cardiovascular Pathology ◽  
Tibial Arteries ◽  
Group I ◽  
Wide Range ◽  
Group Ii

Diabetic polyneuropathy (DP) and angiopathy are interdependent processes, as disturbances in the microcirculatory system of peripheral nerves lead to increased axonal damage and is a kind of predictor of polyneuropathy progressing [6]. 80% of deaths from diabetes mellitus (DM) are associated with cardiovascular catastrophes, including coronary heart disease (CHD), stroke and peripheral artery disease [3]. The objective: to analyze the most common cardiovascular pathology (CVP) and show its impact on the course of DP in type I and II DM. Materials and methods. Was clinically examined 101 patient with DP. The examined patients were divided into groups: with DP on the background of type 1 DM (group I) (n=54) and with DP on the background of type II DM (group II) (n=47), and also were divided into subgroups: DP on the background of type I and II DM and existing CVP (including diabetic angiopathy) 82 (82%) (subgroup А) and with the DP on the background of DM type I and II without CVP – 19 (19%) (subgroup В). Patients were examined to determine the neurological status, were performed laboratory and instrumental methods of examination. Static calculation was performed in MS Excel 2003 and in the programme STATISTICA 10. Results. Regarding to the patients of subgroup А and В we noted the natural predominance of trophic disorders, changes in the reflex sphere and sensitivity in subgroup А. Patients of group II more often than in group I had pathology of the cardiovascular system. Hypertension (HT) and CHD in both cases were registered with a high frequency. In subgroup А there was a combination of several nosologies: from the respiratory, urinary, gastroenterological system (1%), urinary and gastroenterological (3%), gastroenterological and endocrine (2%), urinary and endocrine (1%). In subgroup В diseases of urinary and gastroenterological pathology were found in (5%), gastroenterological (5%), endocrine (11%). The examined patients from group I and with the concomitant CVP have lower linear velocity of blood flow (LVBF) on both tibial arteries, patients in group II – have marginally higher LVBF. Analysis of the results of duplex scanning of lower extremity arteries showed a high incidence of stenosis, in particular the anterior tibial arteries (ATA) up to 30–40%, posterior tibial arteries (PTA) up to 40–50% and occlusion (PTA and femoral, popliteal, tibial segment) in individuals of group I. Conclusions. In patients with DP on the background of type I and II DM and available CVP (subgroup А), the clinical manifestations of polyneuropathy were quite pronounced, especially in the field of trophic disorders, because CVP enhances the ischemia of the microsaceous channel of the peripheral nerves. In addition, persons with concomitant CVP have a wide range of another comorbid pathology, which accelerates the onset of DM complications.

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