scholarly journals Cross-sectional associations of pulmonary function with systemic inflammation and oxidative stress in individuals with chronic spinal cord injury

2015 ◽  
Vol 39 (3) ◽  
pp. 344-352 ◽  
Author(s):  
Jaime E. Hart ◽  
Leslie Morse ◽  
Carlos G. Tun ◽  
Robert Brown ◽  
Eric Garshick
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pulmonary Function ◽  
Systemic Inflammation ◽  
Chronic Spinal Cord Injury ◽  
Cross Sectional ◽  
Cord Injury ◽  
And Oxidative Stress

scholarly journals Systemic Inflammation and Reduced Pulmonary Function in Chronic Spinal Cord Injury

PM&R ◽  
2011 ◽  
Vol 3 (5) ◽  
pp. 433-439 ◽  
Author(s):  
Eric Garshick ◽  
Kelly L. Stolzmann ◽  
David R. Gagnon ◽  
Leslie R. Morse ◽  
Robert Brown
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pulmonary Function ◽  
Systemic Inflammation ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Inhibition of TREM1 reduces inflammation and oxidative stress after spinal cord injury (SCI) associated with HO-1 expressions

2019 ◽  
Vol 109 ◽  
pp. 2014-2021 ◽  
Author(s):  
Zhenhuan Li ◽  
Furong Wu ◽  
Dafeng Xu ◽  
Zhongzheng Zhi ◽  
Guanghui Xu
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
And Oxidative Stress

Effect of Electroacupuncture on Spinal Cord Injury in Mice: Inhibition Of Inflammatory Response and Oxidative Stress via ApoE and Nrf2

2020 ◽  
Author(s):  
Ni Dai ◽  
Chenglin Tang ◽  
Hongdi Zhao ◽  
Pan Dai ◽  
Siqin Huang
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Inflammatory Response ◽  
Inflammatory Cytokines ◽  
Neuroprotective Effect ◽  
Related Factor ◽  
Cord Injury ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Abstract Background: Spinal cord injury (SCI) is a catastrophic central nervous system disease. Inflammatory response and oxidative stress are two critical factors in the pathophysiological process of SCI and closely involved with Apolipoprotein E(ApoE) and Nuclear factor erythroid 2-related factor (Nrf2). Electroacupuncture (EA) has perfectly neuroprotective effect on SCI. However, the underlying mechanism by which EA mediates the inflammatory response and oxidative stress is not completely elucidated. In the present study, we investigated the signaling pathways that EA regulates inflammatory response and oxidative stress through elevation of ApoE and Nrf2 after SCI.Methods: C57BL/6 Wide Type (WT) mice and ApoE -/- mice were subjected to SCI model by a serrefine clamping. Neurological function was detected by BMS scores, ultrastructure of demyelinationed axons was observed by transmission electron microscopy. ApoE, pro- and anti- inflammatory cytokines, oxidative stress-relevant proteins were determined by histochemistry technology. Two-way ANOVA was applied to BMS scores. One-way ANOVA and Bonferroni's multiple comparison test were used to analyse differences among groups.Results: BMS scores were increased gradually and demyelinated axons were improved by EA gradually with the expression of ApoE. EA can inhibit inflammatory response by activation of ApoE, which decreased pro-inflammatory cytokines(TNF-α, IL-6, and IL-1β) expression and increased anti-inflammatory cytokines(IL-10 and TGF-β1).Meanwhile, EA can also inhibit oxidative stress by elevation of Nrf2,which induced HO-1 and NQO1 expression in WT and ApoE -/- mice.Conclusions: EA is a reliable treatment for promoting functional recovery of SCI. Thesynergisticrole of ApoE and Nrf2 in EA regulating inflammatory response and oxidative stress is decisiveto recovery after SCI.

scholarly journals Associations between vitamin D and pulmonary function in chronic spinal cord injury

2018 ◽  
Vol 42 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Eric Garshick ◽  
Palak Walia ◽  
Rebekah L. Goldstein ◽  
Merilee A. Teylan ◽  
Antonio A. Lazzari ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Vitamin D ◽  
Spinal Cord Injury ◽  
Pulmonary Function ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury
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