Impact of Candida isolation in lower respiratory tract samples on the outcomes of acute exacerbation of chronic obstructive pulmonary disease: a retrospective case-control study

2020 ◽  
Author(s):  
Yi-Hui Zuo ◽  
Wei-Qing Wang ◽  
Jing Zhang ◽  
Jie-Ming Qu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Respiratory Tract ◽  
Acute Exacerbation ◽  
Lower Respiratory Tract ◽  
Case Control Study ◽  
Case Control ◽  
Chronic Obstructive ◽  
Retrospective Case ◽  
Obstructive Pulmonary Disease ◽  
Control Study

scholarly journals Clinical features, bacteriology of endotracheal aspirates and treatment outcomes of patients with chronic obstructive pulmonary disease and community-acquired pneumonia in an intensive care unit in Taiwan with an emphasis on eosinophilia versus non-eosinophilia: a retrospective case–control study

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e020341 ◽  
Author(s):  
Wei-Chang Huang ◽  
Ching-Hsiao Lee ◽  
Ming-Feng Wu ◽  
Chen-Cheng Huang ◽  
Cheng-Hui Hsu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Case Control Study ◽  
Case Control ◽  
Community Acquired Pneumonia ◽  
Chronic Obstructive ◽  
Clinical Implications ◽  
Retrospective Case ◽  
Obstructive Pulmonary Disease ◽  
Icu Admission ◽  
Control Study

ObjectivesThe clinical implications of blood eosinophil level in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia (CAP) requiring invasive mechanical ventilation (IMV) and intensive care unit (ICU) admission are still unknown. Thus, this study aimed to compare the features of such patients with and without blood eosinophilia.DesignThis was a retrospective case–control study.SettingAn ICU of a medical centre in central Taiwan.ParticipantsA total of 262 patients with COPD and CAP requiring IMV and ICU admission.ResultsOf all participants (n=262), 32 (12.2%) had an eosinophil percentage (EP) >2% and 169 (64.5%) had an absolute eosinophil count (AEC) >300 cells/µL. Regardless of whether 2% or 300 cells/µL was used as a cut-off value, the eosinophilia group were slightly older (years) (82.9±5.4 vs 78.1±9.1, p=0.000 and 79.2±8.4 vs 77.6±9.6, p=0.246, respectively), and had a higher forced expiratory volume in 1 s/forced vital capacity (%) (56.0±8.0 vs 51.3±11.6, p=0.005 and 53.1±11.2 vs 49.5±11.2, p=0.013, respectively), less severe spirometric classification (p=0.008 and p=0.001, respectively), and lower white cell count 109/L (8.8±3.2 vs 11.1±4.9, p=0.009 and 10.3±4.4 vs 11.8±5.3, p=0.017, respectively) than the non-eosinophilia group. The bacteriology of endotracheal aspirates showed thatPseudomonas aeruginosaand other gram-negative bacilli were the most common organisms in all study groups. Participants with an EP >2% had a shorter ICU length of stay (OR=12.13, p=0.001) than those with an EP ≤2%, while an AEC >300 cells/µL was not associated with any in-ICUoutcomes.ConclusionsThe results of this study have significant clinical implications and should be considered when making treatment decisions for the management of patients with COPD and CAP requiring IMV and ICU admission.

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