Long-term efficacy and cost-effectiveness of polyethylene glycol 3350 plus electrolytes in chronic constipation: a retrospective study in a disabled population

2006 ◽  
Vol 22 (6) ◽  
pp. 1227-1235 ◽  
Author(s):  
I. Migeon-Duballet ◽  
M. Chabin ◽  
A. Gautier ◽  
T. Mistouflet ◽  
M. Bonnet ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Polyethylene Glycol ◽  
Cost Effectiveness ◽  
Chronic Constipation ◽  
Term Efficacy

The Cost-Effectiveness of an RCT to Establish Whether 5 or 10 Years of Bisphosphonate Treatment Is the Better Duration for Women With a Prior Fracture

2009 ◽  
Vol 29 (6) ◽  
pp. 678-689 ◽  
Author(s):  
Matt D. Stevenson ◽  
Jeremy E. Oakley ◽  
Myfawny Lloyd Jones ◽  
Alan Brennan ◽  
Juliet E. Compston ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cost Effective ◽  
Fracture Prevention ◽  
Published Data ◽  
Bisphosphonate Treatment ◽  
Net Benefit ◽  
England And Wales ◽  
Term Efficacy ◽  
The Cost

Purpose. Five years of bisphosphonate treatment have proven efficacy in reducing fractures. Concerns exist that long-term bisphosphonate treatment may actually result in an increased number of fractures. This study evaluates, in the context of England and Wales, whether it is cost-effective to conduct a randomized controlled trial (RCT) and what sample size may be optimal to estimate the efficacy of bisphosphonates in fracture prevention beyond 5 years. Method. An osteoporosis model was constructed to evaluate the cost-effectiveness of extending bisphosphonate treatment from 5 years to 10 years. Two scenarios were run. The 1st uses long-term efficacy data from published literature, and the 2nd uses distributions elicited from clinical experts. Results of a proposed RCT were simulated. The expected value of sample information technique was applied to calculate the expected net benefit of sampling from conducting such an RCT at varying levels of participants per arm and to compare this with proposed trial costs. Results. Without further information, the better duration of bisphosphonate treatment was estimated to be 5 years using the published data but 10 years using the elicited expert opinions, although in both cases uncertainty was substantial. The net benefit of sampling was consistently high when between 2000 and 5000 participants per arm were recruited. Conclusions. An RCT to evaluate the long-term efficacy of bisphosphonates in fracture prevention appears to be cost-effective for informing decision making in England and Wales.

Long-Term Efficacy of Intrathecal Morphine in the Treatment of Nonmalignant Pain: A Retrospective Study

Neurosurgery ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 736-737
Author(s):  
Oren Sagher ◽  
Vishal C. Gala ◽  
Susan Grube ◽  
Randy Roth ◽  
James A. Taren
Keyword(s):  
Retrospective Study ◽  
Intrathecal Morphine ◽  
Term Efficacy ◽  
Nonmalignant Pain

Long-term efficacy and safety of lacosamide and levetiracetam monotherapy in elderly patients with focal epilepsy: A retrospective study

2019 ◽  
Vol 94 ◽  
pp. 178-182 ◽  
Author(s):  
Chiara Del Bianco ◽  
Fabio Placidi ◽  
Claudio Liguori ◽  
Luisa Mari ◽  
Martina Ulivi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Elderly Patients ◽  
Focal Epilepsy ◽  
Efficacy And Safety ◽  
Term Efficacy
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