scholarly journals Identification of a two-marker-haplotype on Bos taurus autosome 18 associated with somatic cell score in German Holstein cattle

BMC Genetics ◽  
2009 ◽  
Vol 10 (1) ◽  
pp. 50 ◽  
Author(s):  
Bodo Brand ◽  
Christine Baes ◽  
Manfred Mayer ◽  
Norbert Reinsch ◽  
Christa Kühn
2019 ◽  
Vol 102 (1) ◽  
pp. 452-463 ◽  
Author(s):  
H.R. Oliveira ◽  
L.F. Brito ◽  
F.F. Silva ◽  
D.A.L. Lourenco ◽  
J. Jamrozik ◽  
...  

2008 ◽  
Vol 39 (4) ◽  
pp. 456-457 ◽  
Author(s):  
E. E. Connor ◽  
L. K. Matukumalli ◽  
A. Chockalingam ◽  
D. D. Bannerman ◽  
T. S. Sonstegard ◽  
...  

2000 ◽  
Vol 83 (4) ◽  
pp. 807-814 ◽  
Author(s):  
H. Castillo-Juarez ◽  
P.A. Oltenacu ◽  
R.W. Blake ◽  
C.E. Mcculloch ◽  
E.G. Cienfuegos-Rivas

2010 ◽  
Vol 90 (2) ◽  
pp. 169-178 ◽  
Author(s):  
C. Baes ◽  
M. Mayer ◽  
J. Tetens ◽  
Z. Liu ◽  
F. Reinhardt ◽  
...  

Genetic selection for udder health is often based on the indicator trait somatic cell score (SCS), which is correlated with clinical mastitis and has a moderate heritability. We used combined linkage and linkage disequilibrium analysis to refine mapping of a previously reported quantitative trait locus (QTL) affecting SCS on Bos taurus autosome 27 (BTA27) in the German Holstein population. A granddaughter design of six grandsire families with 492 sons progeny tested for an average of 190 daughters per son was investigated. Nineteen microsatellite markers were genotyped along a segment of 26.2 cM proximally on BTA27. A chromosome-wide significant QTL was identified between DIK2879 and KIBS272 using combined analysis. The region of interest for future fine mapping experiments was narrowed to the marker interval KIBS272-DIK2191 with a confidence interval of 3.27 cM. The QTL was estimated to be responsible for 18% of the genetic variation in SCS. Application of a 2-QTL model did not result in higher test statistics. Animals likely to be heterozygous or homozygous at the QTL were identified. This study provides a basis for the selection of further markers in linkage disequilibrium with the QTL affecting SCS on BTA27. Key words: Fine-mapping, mastitis, BTA27, somatic cell score, Holstein


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