scholarly journals The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Kimiko Yamakawa-Kobayashi ◽  
Maki Natsume ◽  
Shingo Aoki ◽  
Sachi Nakano ◽  
Tomoko Inamori ◽  
...  
BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e052582
Author(s):  
Martin Holmbom ◽  
Maria Andersson ◽  
Sören Berg ◽  
Dan Eklund ◽  
Pernilla Sobczynski ◽  
...  

ObjectivesThe aim of this study was to identify prehospital and early hospital risk factors associated with 30-day mortality in patients with blood culture-confirmed community-acquired bloodstream infection (CA-BSI) in Sweden.MethodsA retrospective case–control study of 1624 patients with CA-BSI (2015–2016), 195 non-survivors satisfying the inclusion criteria were matched 1:1 with 195 survivors for age, gender and microorganism. All forms of contact with a healthcare provider for symptoms of infection within 7 days prior CA-BSI episode were registered. Logistic regression was used to analyse risk factors for 30-day all-cause mortality.ResultsOf the 390 patients, 61% (115 non-survivors and 121 survivors) sought prehospital contact. The median time from first prehospital contact till hospital admission was 13 hours (6–52) for non-survivors and 7 hours (3–24) for survivors (p<0.01). Several risk factors for 30-day all-cause mortality were identified: prehospital delay OR=1.26 (95% CI: 1.07 to 1.47), p<0.01; severity of illness (Sequential Organ Failure Assessment score) OR=1.60 (95% CI: 1.40 to 1.83), p<0.01; comorbidity score (updated Charlson Index) OR=1.13 (95% CI: 1.05 to 1.22), p<0.01 and inadequate empirical antimicrobial therapy OR=3.92 (95% CI: 1.64 to 9.33), p<0.01. In a multivariable model, prehospital delay >24 hours from first contact remained an important risk factor for 30-day all-cause mortality due to CA-BSI OR=6.17 (95% CI: 2.19 to 17.38), p<0.01.ConclusionPrehospital delay and inappropriate empirical antibiotic therapy were found to be important risk factors for 30-day all-cause mortality associated with CA-BSI. Increased awareness and earlier detection of BSI in prehospital and early hospital care is critical for rapid initiation of adequate management and antibiotic treatment.


Tumor Biology ◽  
2015 ◽  
Vol 37 (4) ◽  
pp. 4721-4726 ◽  
Author(s):  
Yanli Shao ◽  
Shijie Cheng ◽  
Jianqing Hou ◽  
Ying Zuo ◽  
Wei Zheng ◽  
...  

2019 ◽  
Vol 143 (2) ◽  
pp. AB106
Author(s):  
Bong Seok Choi ◽  
Editt Nikoyan ◽  
Chung-Il Wi ◽  
Katherine S. King ◽  
Euijung Ryu ◽  
...  

2011 ◽  
Vol 9 (1) ◽  
pp. 71-78 ◽  
Author(s):  
L. M. HILTUNEN ◽  
H. LAIVUORI ◽  
A. RAUTANEN ◽  
R. KAAJA ◽  
J. KERE ◽  
...  

2007 ◽  
Vol 102 (1) ◽  
pp. 122-131 ◽  
Author(s):  
Eric Lerebours ◽  
Corinne Gower-Rousseau ◽  
Veronique Merle ◽  
Franck Brazier ◽  
Stephane Debeugny ◽  
...  

BMJ Open ◽  
2014 ◽  
Vol 4 (6) ◽  
pp. e005133-e005133 ◽  
Author(s):  
J. Almirall ◽  
M. Serra-Prat ◽  
I. Bolibar ◽  
E. Palomera ◽  
J. Roig ◽  
...  

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178571 ◽  
Author(s):  
Sai-Wai Ho ◽  
Chao-Bin Yeh ◽  
Shun-Fa Yang ◽  
Han-Wei Yeh ◽  
Jing-Yang Huang ◽  
...  

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