scholarly journals Urinary kidney injury molecule-1 is related to pathologic involvement in IgA nephropathy with normotension, normal renal function and mild proteinuria

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Peng-cheng Xu ◽  
Li Wei ◽  
Wen-ya Shang ◽  
Shun-li Tian ◽  
Dong-mei Gu ◽  
...  
Keyword(s):  
Renal Function ◽  
Iga Nephropathy ◽  
Normal Renal Function ◽  
Kidney Injury ◽  
Kidney Injury Molecule 1

scholarly journals Immunoglobulin A Nephropathy as the First Clinical Presentation of Wilson Disease: A Case Report and Literature Review

2021 ◽  
Author(s):  
Yong-Zhe Zhang ◽  
Geng Jian ◽  
Ping He ◽  
Rui Yu ◽  
Mi Tian ◽  
...  
Keyword(s):  
Renal Function ◽  
Iga Nephropathy ◽  
Wilson Disease ◽  
Genetic Disorder ◽  
Immunoglobulin A ◽  
Elevated Serum ◽  
Clinical Manifestations ◽  
Kidney Injury ◽  
Copper Metabolism ◽  
Normal Liver

Abstract Background: Wilson disease (WD) is a rare genetic disorder of copper metabolism. The difference in copper tissue accumulation lead to various clinical manifestations, including some atypical presentations. The complex clinical picture makes it easy to miss and misdiagnose, even delay the best chance for treatment. Case presentation: A 26-year-old male patient who had nephritis-range proteinuria and elevated serum creatinine. The renal pathology indicated Immunoglobulin A (IgA) nephropathy and tubular injury which was inconsistent with glomerular lesions. Cirrhosis was also detected by imaging examination. Considering both kidney injury and liver damage, WD was suspected. According to further detected results of abnormal copper metabolism, corneal Kayser-Fleischer rings(K-F rings), and genetic disorder of ATP7B gene, he was finally diagnosed as a case of WD.The patient was given oral penicillamine and zinc sulfate daily and he was also prescribed losartan to control proteinuria on the premise of monitoring renal function and blood pressure. During the 2 years follow-up, the patient’s 24h uric cooper dropped to normal. The sign of tremor hands disappeared. The Urine protein and renal function keep stable. The patient had normal liver function and maintained good quality of daily life. Conclusions: In some cases, IgA nephropathy patients with suspicious and unexplained neurological and liver symptoms cannot be ignored. They may eventually be diagnosed with WD.

scholarly journals The Effect of Acetylcysteine on Renal Function in Experimental Models of Cyclophosphamide-and Ifosfamide-Induced Cystitis

2020 ◽  
Vol 14 (3) ◽  
pp. 150-162
Author(s):  
Lukasz Dobrek ◽  
Klaudia Nalik-Iwaniak ◽  
Kinga Fic ◽  
Zbigniew Arent
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Kidney Injury ◽  
Blood Parameters ◽  
Experimental Models ◽  
Histopathological Analysis ◽  
Urinary Ph ◽  
Kidney Injury Molecule 1 ◽  
Potential Use ◽  
Group 1

<b><i>Introduction</i></b>: Urotoxicity is a characteristic attribute of cy-clophosphamide and ifosfamide. Acetylcysteine is perceived as a uroprotective and possible nephroprotective compound. The purpose of the study was to assess the effect of acetylcysteine treatment on the morphology of the kidneys and the urinary bladder, and renal function in rats with cystitis induced by cyclophosphamide or ifosfamide. <b><i>Methods</i></b>: Cystitis was induced in rats belonging to groups 2 and 3, as well as 4 and 5, by five administrations of cyclophosphamide (75 mg/kg) or ifosfamide (80 mg/kg) respectively. Additionally, groups 3 and 5 received acetylcysteine (200 mg/kg). Group 1 was “sham treated” as a control. Upon conclusion of the experiment, the animals were euthanized and their kidneys and urinary bladders were collected for histopathological analysis. The assessment of renal function was based on classic nitrogen blood parameters (urea, creatinine, and uric acid), as well as proteinuria and cystatin C (CysC) and kidney injury molecule-1 (KIM-1) urinary concentrations, and their 24-hour elimination with urine. <b><i>Results</i></b>: Reduction of blood urea nitrogen and uric acid, and urinary pH with a significant increase of CysC and KIM-1 urinary concentrations, and their 24-hour elimination with urine were observed in groups 2 and 4. The acetylcysteine treatment did not cause a significant change of blood parameters, but significantly decreased 24-hour elimination of CysC and KIM-1 with urine, and accounted for alleviation of the histopathological abnormalities of urinary bladders, with no significant effects on the structure of the kidneys. <b><i>Conclusions</i></b>: Acetylcysteine used in the experimental model of cyclophosphamide- and ifosfamide-induced cystitis had a uroprotective effect and also reduced renal dysfunction, which suggests its potential use as a nephroprotective compound in cyclophosphamide/ifosfamide therapy.

scholarly journals Effect of treatment on urinary kidney injury molecule-1 in IgA nephropathy

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Mi Seon Seo ◽  
Moo Yong Park ◽  
Soo Jeong Choi ◽  
Jin Seok Jeon ◽  
Hyunjin Noh ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Kidney Injury ◽  
Effect Of Treatment ◽  
Kidney Injury Molecule 1

scholarly journals Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy

2013 ◽  
Vol 35 ◽  
pp. 567-572 ◽  
Author(s):  
Sanja Simic Ogrizovic ◽  
Suzana Bojic ◽  
Gordana Basta-Jovanovic ◽  
Sanja Radojevic ◽  
Jelena Pavlovic ◽  
...  
Keyword(s):  
Renal Function ◽  
Retrospective Study ◽  
Kidney Function ◽  
Kidney Biopsy ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Mdrd Formula ◽  
Positive Correlations ◽  
Kidney Injury Molecule 1 ◽  
Kidney Functions

Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy.Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later.Results. Significantly positive correlations between tissue KIM-1 expression and age (r=0.313), TIN inflammation (r=0.456), fibrosis (r=0.317), and proteinuria at 6 months (r=0.394) as well as negative correlations with GFR0 (r=−0.572), GFR6 (r=−0.442), GFR24 (r=−0.398), and GFR36 (r=−0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P=0.016) was a predictor only at 6 months after biopsy.Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.

scholarly journals Acute kidney injury and acyclovir-associated encephalopathy after administration of valacyclovir in an elderly person with normal renal function

Medicine ◽  
2021 ◽  
Vol 100 (21) ◽  
pp. e26147
Author(s):  
Tsuneaki Kenzaka ◽  
Kazuma Sugimoto ◽  
Ken Goda ◽  
Hozuka Akita
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Normal Renal Function ◽  
Elderly Person ◽  
Kidney Injury

scholarly journals Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction

2020 ◽  
Vol 21 (15) ◽  
pp. 5490 ◽  
Author(s):  
Satoshi Washino ◽  
Keiko Hosohata ◽  
Tomoaki Miyagawa
Keyword(s):  
Renal Function ◽  
Urinary Tract ◽  
Interstitial Fibrosis ◽  
Urinary Tract Obstruction ◽  
Kidney Injury ◽  
Upper Urinary Tract ◽  
Obstructive Nephropathy ◽  
Ureteral Stricture ◽  
Kidney Injury Molecule 1 ◽  
Upper Urinary Tract Obstruction

Partial or complete obstruction of the urinary tract is a common and challenging urological condition caused by a variety of conditions, including ureteral calculi, ureteral pelvic junction obstruction, ureteral stricture, and malignant ureteral obstruction. The condition, which may develop in patients of any age, induces tubular and interstitial injury followed by inflammatory cell infiltration and interstitial fibrosis, eventually impairing renal function. The serum creatinine level is commonly used to evaluate global renal function but is not sensitive to early changes in the glomerular filtration rate and unilateral renal damage. Biomarkers of acute kidney injury are useful for the early detection and monitoring of kidney injury induced by upper urinary tract obstruction. These markers include levels of neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemotactic protein-1, kidney injury molecule 1, N-acetyl-b-D-glucosaminidase, and vanin-1 in the urine and serum NGAL and cystatin C concentrations. This review summarizes the pathophysiology of kidney injury caused by upper urinary tract obstruction, the roles played by emerging biomarkers of obstructive nephropathy, the mechanisms involved, and the clinical utility and limitations of the biomarkers.

scholarly journals PROGNOSIS SIGNIFICANCE OF CONTRAST-INDUCED ACUTE KIDNEY INJURY IN PATIENTS WITH PREVIOUSLY NORMAL RENAL FUNCTION (UP TO 2 YEARS FOLLOW UP)

2014 ◽  
Vol 63 (12) ◽  
pp. A1853
Author(s):  
Ester Canovas Rodriguez ◽  
Lorenzo Hernando Marrupe ◽  
Alfonso Freites Esteves ◽  
Adriana De La Rosa Riestra ◽  
Javier Alonso Bello ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Normal Renal Function ◽  
Kidney Injury

Kidney injury molecule-1 expression in IgA nephropathy and its correlation with hypoxia and tubulointerstitial inflammation

2014 ◽  
Vol 306 (8) ◽  
pp. F885-F895 ◽  
Author(s):  
Qiongzhen Lin ◽  
Ying Chen ◽  
Jicheng Lv ◽  
Hong Zhang ◽  
Jiawei Tang ◽  
...  
Keyword(s):  
Renal Function ◽  
Iga Nephropathy ◽  
Renal Injury ◽  
Kidney Injury ◽  
Inflammatory Cells ◽  
Capillary Density ◽  
Clinicopathological Parameters ◽  
Tubulointerstitial Injury ◽  
Tubulointerstitial Inflammation

Tubulointerstitial injury plays an important role in the development and progression of chronic kidney disease (CKD). Kidney injury molecule (KIM)-1 is induced in damaged proximal tubules in both acute renal injury and CKD. However, the dynamics of KIM-1 in CKD and effects of KIM-1 expression on disease progression are unknown. Here, we aimed to determine the associations between tubular KIM-1 expression levels, renal function, and inflammation in CKD. The relationships between levels of KIM-1 and clinicopathological parameters were analyzed in patients with progressive and nonprogressive IgA nephropathy. KIM-1 expression was increased in patients with IgA nephropathy, and its expression was significantly correlated with the decrease of renal function. KIM-1 was particularly evident at the site with reduced capillary density, and KIM-1-positive tubules were surrounded by infiltrates of inflammatory cells. Using in vitro cell models, we showed that cellular stressors, including hypoxia, induced KIM-1 expression. KIM-1-expressing cells produced more chemokines/cytokines when cultured under hypoxic conditions. Furthermore, we showed that tubular cells with KIM-1 expression can regulate the immune response of inflammatory cells through the secretion of chemotactic factors. These data suggest that KIM-1-expressing epithelial cells may play a role in the pathogenesis of tubulointerstitial inflammation during chronic renal injury through the secretion of chemokines/cytokines.

Sign in / Sign up

Export Citation Format

Share Document