scholarly journals Left atrial blood stasis by 4D flow MRI correlates with stroke risk estimation by CHA2DS2-VASc score

2014 ◽  
Vol 16 (S1) ◽  
Author(s):  
Daniel C Lee ◽  
Michael Markl ◽  
Jacob Fluckiger ◽  
Jason Ng ◽  
James C Carr ◽  
...  
Keyword(s):  
Left Atrial ◽  
Stroke Risk ◽  
Risk Estimation ◽  
Blood Stasis ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri

Abstract 14026: Atrial Fibrillation is Associated with Altered Left Atrial 3D Hemodynamics and Increased Stasis

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Daniel C Lee ◽  
Michael Markl ◽  
Jason Ng ◽  
Maria Carr ◽  
Brandon C Benefield ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Stroke Risk ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
4D Flow Mri ◽  
4D Flow ◽  
Data Set ◽  
Ventricular Ejection Fraction ◽  
Flow Mri

Introduction: Clinical scores used for stroke risk estimation in atrial fibrillation (AF) have limited predictive accuracy. 4D Flow MRI can acquire blood flow in a volume data set encompassing the entire left atrium (LA) with quantification of blood velocity in 3 orthogonal directions for every voxel at multiple time points throughout the cardiac cycle (4D = 3D coverage + time). Hypothesis: 4D Flow MRI can assess 3D LA flow abnormalities in AF patients, which may potentially be linked to stroke. Methods: We performed 4D flow MRI in 30 volunteers (10 young, 20 older) and 70 patients with a history of AF: 40 in sinus rhythm (AF-sinus) and 30 in AF during MRI scan (AF-afib). The typical LA contained 3000 voxels and 18 phases per voxel. LA flow velocity histograms for each patient were quantified by mean LA velocity, median LA velocity, and the percentage of LA velocities < 0.2 m/s (%stasis). CHA2DS2-VASc scores were calculated for each patient. Results: Mean LA velocity, median LA velocity, and %stasis were significantly different between groups: young volunteers (0.26±0.02 m/s, 0.23±0.02 m/s, 37.3±7.6%), older volunteers (0.21±0.03 m/s, 0.20±0.03 m/s, 52.2±16.0%), AF-sinus (0.18±0.03 m/s, 0.17±0.03 m/s, 67.5±16.9%), and AF-afib (0.16±0.01 m/s, 0.14±0.03 m/s, 78.2±12.9%), p < 0.0125 for all comparisons. CHA2DS2-VASc had moderate but significant correlations with mean LA velocity (R 2 =0.27, p<0.001), median LA velocity (R 2 =0.23, p<0.001), and stasis% (R 2 =0.26, p<0.001). LA flow indices also correlated significantly with age, LA volume, and left ventricular ejection fraction (LVEF) as seen in the Table. Conclusions: Left atrial 4D flow MRI is a novel approach to identify patients with reduced LA blood velocities and increased LA stasis. Further study is needed to determine whether these measures can improve upon the CHA2DS2-VASc score for stroke risk prediction and enhance individual decisions on anticoagulation in patients with AF.

scholarly journals B-PO04-077 HEART RATE VARIABILITY AND LEFT ATRIAL HEMODYNAMICS IN ATRIAL FIBRILLATION MEASURED WITH 4D FLOW MRI

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S310
Author(s):  
Amanda DiCarlo ◽  
Justin Baraboo ◽  
Mitchell A. Collins ◽  
Maurice Pradella ◽  
Patrick M. McCarthy ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Left Atrial ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri

scholarly journals Quantification of left atrial flow velocity distribution in atrial fibrillation using 4D flow MRI

2013 ◽  
Vol 15 (S1) ◽  
Author(s):  
Jacob U Fluckiger ◽  
Jeffrey J Goldberger ◽  
Daniel C Lee ◽  
Jason Ng ◽  
Richard Lee ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Velocity Distribution ◽  
Flow Velocity ◽  
Left Atrial ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri

scholarly journals Fixed volume particle trace emission for the analysis of left atrial blood flow using 4D Flow MRI

2018 ◽  
Vol 47 ◽  
pp. 83-88 ◽  
Author(s):  
Stephen Gaeta ◽  
Petter Dyverfeldt ◽  
Jonatan Eriksson ◽  
Carl-Johan Carlhäll ◽  
Tino Ebbers ◽  
...  
Keyword(s):  
Blood Flow ◽  
Left Atrial ◽  
4D Flow Mri ◽  
4D Flow ◽  
Fixed Volume ◽  
Particle Trace ◽  
Flow Mri

4D-Flow MRI: Beyond the Images

2020 ◽  
Vol 32 (1) ◽  
pp. 35
Author(s):  
Pietro Sergio ◽  
Antonio Miceli
Keyword(s):  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri
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